Kayenat Parveen
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View article: Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL‐40 and NfL biomarkers
Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL‐40 and NfL biomarkers Open
View article: Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease
Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease Open
Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the unde…
View article: African ancestry component could change APOE4 effect size for AD of a diverse population
African ancestry component could change APOE4 effect size for AD of a diverse population Open
Background Worldwide, the actual number of 55 million people diagnosed with dementia is estimated to increase to 139 million people affected by dementia in 2050. 61% of these individuals resided in low and middle‐income countries (LMIC). G…
View article: Systematic Review: Vitamin D Deficiency in Women and Correlation with Lifestyle for Women: A Focus on Asian Women
Systematic Review: Vitamin D Deficiency in Women and Correlation with Lifestyle for Women: A Focus on Asian Women Open
Inadequate vitamin D levels are a worldwide health problem that threatens not just bone health but also other aspects of human wellness. Because Asian women are a distinct demographic shaped by culture, location, and personal decisions, th…
View article: Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by <i>HLA-DRB1*04</i> subtypes
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by <i>HLA-DRB1*04</i> subtypes Open
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same…
View article: Methylation age and inflammation in prodromal Alzheimer’s disease
Methylation age and inflammation in prodromal Alzheimer’s disease Open
Background The most relevant risk factor in Alzheimer’s disease (AD) is age. Aging is a complex process involving several biological changes which lead to chronic cellular stress and to a sterile tissue inflammation. During aging cells bec…
View article: Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease Open
Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk fact…
View article: Identification of a sex-specific genetic signature in dementia with Lewy bodies: a meta-analysis of genome-wide association studies
Identification of a sex-specific genetic signature in dementia with Lewy bodies: a meta-analysis of genome-wide association studies Open
Background Genome-wide Association Studies (GWAS) have reshaped our understanding of the genetic bases of complex diseases in general and neurodegenerative diseases in particular. Despite being a common disorder, dementia with Lewy bodies …
View article: Protective association of HLA-DRB1*04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequences
Protective association of HLA-DRB1*04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequences Open
Using genome-wide association data, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s (PD) or Alzheimer’s (AD) disease versus controls across ancestry groups. A shared genetic association w…
View article: Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping
Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping Open
View article: Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer’s type
Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer’s type Open
Alzheimer’s disease has a long asymptomatic phase that offers a substantial time window for intervention. Using this window of opportunity will require early diagnostic and prognostic biomarkers to detect Alzheimer’s disease pathology at p…
View article: Protective association of <i>HLA-DRB1</i>*04 subtypes in neurodegenerative diseases implicates acetylated Tau PHF6 sequences
Protective association of <i>HLA-DRB1</i>*04 subtypes in neurodegenerative diseases implicates acetylated Tau PHF6 sequences Open
Using genome-wide association data, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s (PD) or Alzheimer’s (AD) disease versus controls across ancestry groups. A shared genetic association w…
View article: Challenges at the <i>APOE</i> locus: A robust quality control approach for accurate <i>APOE</i> genotyping
Challenges at the <i>APOE</i> locus: A robust quality control approach for accurate <i>APOE</i> genotyping Open
Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE *2/3/4 genotypes. Identifying such variants and mechanisms would importantly advance our understanding o…