Kayla M. Socarras
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View article: GREGoR: accelerating genomics for rare diseases
GREGoR: accelerating genomics for rare diseases Open
View article: Evidence for the Presence of Borrelia burgdorferi Biofilm in Infected Mouse Heart Tissues
Evidence for the Presence of Borrelia burgdorferi Biofilm in Infected Mouse Heart Tissues Open
Borrelia burgdorferi, the bacterium responsible for Lyme disease, has been shown to form antimicrobial-tolerant biofilms, which protect it from unfavorable conditions. Bacterial biofilms are known to significantly contribute to severe infl…
View article: Characterization of the family-level Borreliaceae pan-genome and development of an episomal typing protocol
Characterization of the family-level Borreliaceae pan-genome and development of an episomal typing protocol Open
Background The Borreliaceae family includes many obligate parasitic bacterial species which are etiologically associated with a myriad of zoonotic borrelioses including Lyme disease and vector-borne relapsing fevers. Infections by the Borr…
View article: P575: The Rare Genomes Project: Improving access to genomic sequencing and identifying causes of rare disease*
P575: The Rare Genomes Project: Improving access to genomic sequencing and identifying causes of rare disease* Open
The majority of patients with rare, suspected monogenic conditions do not have a molecular diagnosis. As management and treatments for rare diseases improve, the implications of a diagnosis broaden and keep these patients and their provide…
View article: Large-Scale Sequencing of Borreliaceae for the Construction of Pan-Genomic-Based Diagnostics
Large-Scale Sequencing of Borreliaceae for the Construction of Pan-Genomic-Based Diagnostics Open
The acceleration of climate change has been associated with an alarming increase in the prevalence and geographic range of tick-borne diseases (TBD), many of which have severe and long-lasting effects—particularly when treatment is delayed…
View article: Species-Level Profiling of <i>Ixodes pacificus</i> Bacterial Microbiomes Reveals High Variability Across Short Spatial Scales at Different Taxonomic Resolutions
Species-Level Profiling of <i>Ixodes pacificus</i> Bacterial Microbiomes Reveals High Variability Across Short Spatial Scales at Different Taxonomic Resolutions Open
Background and Aims: Outbreaks of severe and chronic tick-borne diseases (TBDs) are on the rise. This is through the transmission of infectious disease agents to humans during tick feeding. The transmission rate and extent of…
View article: Beyond the pan-genome: current perspectives on the functional and practical outcomes of the distributed genome hypothesis
Beyond the pan-genome: current perspectives on the functional and practical outcomes of the distributed genome hypothesis Open
The principle of monoclonality with regard to bacterial infections was considered immutable prior to 30 years ago. This view, espoused by Koch for acute infections, has proven inadequate regarding chronic infections as persistence requires…
View article: Antimicrobial Activity of Bee Venom and Melittin against Borrelia burgdorferi
Antimicrobial Activity of Bee Venom and Melittin against Borrelia burgdorferi Open
Lyme disease is a tick-borne, multi-systemic disease, caused by the bacterium Borrelia burgdorferi. Though antibiotics are used as a primary treatment, relapse often occurs after the discontinuation of antimicrobial agents. The reason for …
View article: Evidence of in vivo existence of Borrelia biofilm in borrelial lymphocytomas
Evidence of in vivo existence of Borrelia biofilm in borrelial lymphocytomas Open
Lyme borreliosis, caused by the spirochete Borrelia burgdorferi sensu lato , has grown into a major public health problem. We recently identified a novel morphological form of B. burgdorferi , called biofilm, a structure that is well known…
View article: Effectiveness of Stevia rebaudiana whole leaf extract against the various morphological forms of Borrelia burgdorferi in vitro
Effectiveness of Stevia rebaudiana whole leaf extract against the various morphological forms of Borrelia burgdorferi in vitro Open
Lyme disease is a tick-borne multisystemic disease caused by Borrelia burgdorferi . Administering antibiotics is the primary treatment for this disease; however, relapse often occurs when antibiotic treatment is discontinued. The reason fo…