Kazunari K. Yokoyama
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View article: New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets
New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets Open
The aryl hydrocarbon receptor (AHR) plays crucial roles in the control of stress, xenobiotic metabolism, inflammation, and cancer. However, information on the chromatin regulation of ligand-dependent AHR promoter activation is limit…
View article: The AHR–NRF2–JDP2 gene battery: Ligand–induced AHR transcriptional activation
The AHR–NRF2–JDP2 gene battery: Ligand–induced AHR transcriptional activation Open
Aryl hydrocarbon receptor (AHR) and nuclear factor-erythroid 2-related factor 2 (NRF2) can regulate a series of genes encoding the detoxifying phase I and II enzymes, via a signaling crosstalk known as the "AHR-NRF2 gene battery". The chro…
View article: Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells
Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells Open
The Jun dimerization protein ( Jdp2 ) gene is active in mouse cerebellar granule cells and its protein product plays a crucial role in the formation of the cerebellum lobes through programmed cell death. However, the role of Jdp2 in cellul…
View article: Vulnerability of Antioxidant Drug Therapies on Targeting the Nrf2-Trp53-Jdp2 Axis in Controlling Tumorigenesis
Vulnerability of Antioxidant Drug Therapies on Targeting the Nrf2-Trp53-Jdp2 Axis in Controlling Tumorigenesis Open
Control of oxidation/antioxidation homeostasis is important for cellular protective functions, and disruption of the antioxidation balance by exogenous and endogenous ligands can lead to profound pathological consequences of cancerous comm…
View article: Vulnerability of antioxidant drug therapies on targeting Nrf2-Trp53-Jdp2 axis in controlling the tumorigenesis
Vulnerability of antioxidant drug therapies on targeting Nrf2-Trp53-Jdp2 axis in controlling the tumorigenesis Open
Control of oxidation/antioxidation homeostasis is important for cellular protective functions, and disruption of the antioxidation balance by exogenous and endogenous ligands can lead to profound pathological consequences of cancerous comm…
View article: Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells
Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells Open
The Jun dimerization protein (Jdp2) gene is active in mouse cerebellar granule cells and its protein product plays a crucial role in the formation of the cerebellum lobes through programmed cell death. However, the role of Jdp2 in cellular…
View article: Possible Strategies to Reduce the Tumorigenic Risk of Reprogrammed Normal and Cancer Cells
Possible Strategies to Reduce the Tumorigenic Risk of Reprogrammed Normal and Cancer Cells Open
The reprogramming of somatic cells to pluripotent stem cells has immense potential for use in regenerating or redeveloping tissues for transplantation, and the future application of this method is one of the most important research topics …
View article: Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1
Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1 Open
An understanding of the risk of gene deletion and mutation posed by endocrine-disrupting chemicals (EDCs) is necessary for the identification of etiological reagents for many human diseases. Therefore, the characterization of the genetic t…
View article: Heterogeneity of Phase II Enzyme Ligands on Controlling the Progression of Human Gastric Cancer Organoids as Stem Cell Therapy Model
Heterogeneity of Phase II Enzyme Ligands on Controlling the Progression of Human Gastric Cancer Organoids as Stem Cell Therapy Model Open
Gastric cancer (GC) organoids are frequently used to examine cell proliferation and death as well as cancer development. Invasion/migration assay, xenotransplantation, and reactive oxygen species (ROS) production were used to examine the e…
View article: Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery Open
Background Crosstalk between the aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is called the “AhR–Nrf2 gene battery”, which works synergistically in detoxification to support cell survival…
View article: Data from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Data from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
The intestine-specific homeobox transcription factor intestine-specific homeobox (ISX) is an IL6-inducible proto-oncogene implicated in the development of hepatocellular carcinoma, but its mechanistic contributions to this process are unde…
View article: Figure S5 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S5 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S5, A, Western blots analysis of IDOs, AHR, PD-L1 and CD86 protein expression in various hepatoma cells. CNL: Chang normal liver cells. B, The Kaplan-Meier survival curve analysis between HCC patients with low and high expression of…
View article: Figure S4 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S4 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S4, A to I, The ISX mRNA expression showed a strong correlation with the mRNA expression of well-known immunosuppressive genes, including IDO1 (A), TDO2 (C), KYNU (D), AHR (E), CD80 (F), CD86 (G), PD-L1 (H) and RB (I) in HCC tumors.…
View article: Independent Signaling of Hepatoma Derived Growth Factor and Tumor Necrosis Factor-Alpha in Human Gastric Cancer Organoids Infected by Helicobacter pylori
Independent Signaling of Hepatoma Derived Growth Factor and Tumor Necrosis Factor-Alpha in Human Gastric Cancer Organoids Infected by Helicobacter pylori Open
We prepared three-dimensional (3-D) organoids of human stomach cancers and examined the correlation between the tumorigenicity and cytotoxicity of Helicobacter pylori (H. pylori). In addition, the effects of hepatoma-derived growth factor …
View article: Supplementary Figure Legends from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Supplementary Figure Legends from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Supplementary Information
View article: Figure S3 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S3 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S3, A, Western blotting analysis of ISX, IDO1, TDO2, KYNU, and CYP1B1proteins in hepatocytes of AhR-null mice with treated proinflammatory cytokine IL-6 (10 ng/ml) B, The levels of kynurenine in hepatocytes of AHR+/+, AHR+/â^'and AH…
View article: Figure S2 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S2 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S2, AHR signals positively activated ISX expression in hepatoma cells. A, Relative mRNA expression levels of CYP1B1 and ISX in Hep 3B and SK-Hep1 cells with AHR overexpression as detected by semi-quantitative RT-PCR. Data are presen…
View article: Data from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Data from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
The intestine-specific homeobox transcription factor intestine-specific homeobox (ISX) is an IL6-inducible proto-oncogene implicated in the development of hepatocellular carcinoma, but its mechanistic contributions to this process are unde…
View article: Figure S4 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S4 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S4, A to I, The ISX mRNA expression showed a strong correlation with the mRNA expression of well-known immunosuppressive genes, including IDO1 (A), TDO2 (C), KYNU (D), AHR (E), CD80 (F), CD86 (G), PD-L1 (H) and RB (I) in HCC tumors.…
View article: Figure S1 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S1 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S1. ISX activated transcription of IDOs, AHR, CD86, and PD-L1 in hepatoma cells by binding to the promoter region. a, p < 0.001. A, ISX transcriptionally activated luciferase activity driven by IDO1, TDO2 B, PD-L1 and CD86 C, and AH…
View article: Figure S5 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S5 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S5, A, Western blots analysis of IDOs, AHR, PD-L1 and CD86 protein expression in various hepatoma cells. CNL: Chang normal liver cells. B, The Kaplan-Meier survival curve analysis between HCC patients with low and high expression of…
View article: Figure S3 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S3 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S3, A, Western blotting analysis of ISX, IDO1, TDO2, KYNU, and CYP1B1proteins in hepatocytes of AhR-null mice with treated proinflammatory cytokine IL-6 (10 ng/ml) B, The levels of kynurenine in hepatocytes of AHR+/+, AHR+/â^'and AH…
View article: Figure S1 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S1 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S1. ISX activated transcription of IDOs, AHR, CD86, and PD-L1 in hepatoma cells by binding to the promoter region. a, p < 0.001. A, ISX transcriptionally activated luciferase activity driven by IDO1, TDO2 B, PD-L1 and CD86 C, and AH…
View article: Figure S2 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Figure S2 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Figure S2, AHR signals positively activated ISX expression in hepatoma cells. A, Relative mRNA expression levels of CYP1B1 and ISX in Hep 3B and SK-Hep1 cells with AHR overexpression as detected by semi-quantitative RT-PCR. Data are presen…
View article: Supplementary Figure Legends from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Supplementary Figure Legends from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open
Supplementary Information
View article: Additional file 1 of Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery
Additional file 1 of Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery Open
Additional file 1: Supplementary Figure S1. Luciferase activity driven by the Cyp1b1 promoter in response to TCDD. Supplementary Figure S2. Characteristics of AhR protein expression and effects of Jdp2 on AhR expression. Supplementary Figu…
View article: FOXM1-CD44 Signaling Is Critical for the Acquisition of Regorafenib Resistance in Human Liver Cancer Cells
FOXM1-CD44 Signaling Is Critical for the Acquisition of Regorafenib Resistance in Human Liver Cancer Cells Open
Regorafenib is a multikinase inhibitor that was approved by the US Food and Drug administration in 2017. Cancer stem cells (CSCs) are a small subset of cancer-initiating cells that are thought to contribute to therapeutic resistance. The f…
View article: Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer
Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer Open
Stomach cancer has a high mortality, which is partially caused by an absence of suitable biomarkers to allow detection of the initiation stages of cancer progression. Thus, identification of critical biomarkers associated with gastric canc…
View article: Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application
Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application Open
The use of biomarkers in cancer diagnosis, therapy, and prognosis has been highly effective over several decades. Studies of biomarkers in cancer patients pre- and post-treatment and during cancer progression have helped identify cancer st…
View article: Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research
Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research Open
There is considerable cellular diversity in the human stomach, which has helped to clarify cell plasticity in normal development and tumorigenesis. Thus, the stomach is an interesting model for understanding cellular plasticity and for dev…