Kayoko Shimoi
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View article: Social confrontation stress decreases hepatic fibroblast growth factor-21 expression in aged mice
Social confrontation stress decreases hepatic fibroblast growth factor-21 expression in aged mice Open
View article: Effect of flavonoid-rich meals and low-flavonoid meals based on the dietary reference intakes for Japanese, using basic foodstuffs on the gene expression of inflammatory cytokines in the whole blood cells from adult men of normal or light overweight
Effect of flavonoid-rich meals and low-flavonoid meals based on the dietary reference intakes for Japanese, using basic foodstuffs on the gene expression of inflammatory cytokines in the whole blood cells from adult men of normal or light overweight Open
Introduction: Flavonoids have a variety of functions, such as antioxidant activity, and are expected to have a disease prevention effect. In order to verify the disease risk reduction effect of flavonoids, we carried out a crossover trial …
View article: Metastasis of Breast Cancer Promoted by Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice
Metastasis of Breast Cancer Promoted by Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice Open
Epidemiological studies have indicated that a disturbed circadian rhythm resulting from night-shift work is a potential risk factor for breast cancer. However, the mechanism of increased risk of breast cancer by night-shift work remains un…
View article: Omega-3 Eicosapentaenoic Acid Is Related to Happiness and a Sense of Fulfillment—A Study among Female Nursing Workers
Omega-3 Eicosapentaenoic Acid Is Related to Happiness and a Sense of Fulfillment—A Study among Female Nursing Workers Open
Background: Omega (ω) 3 fatty acid (FA) is a polyunsaturated FA (PUFA) that can modulate some mental statuses. However, most studies have not considered the functional differences between eicosapentaenoic acid (EPA) and docosahexaenoic aci…
View article: Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-<i>Lepr</i><i><sup>fa</sup></i> (SDT fatty) rats and Sprague-Dawley rats
Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-<i>Lepr</i><i><sup>fa</sup></i> (SDT fatty) rats and Sprague-Dawley rats Open
One of the risk factors for drug-induced liver injury (DILI) is the diabetic state. Our previous investigation showed that liver injury after repeated oral dosing with allyl alcohol and carbamazepine was enhanced more in the Spontaneously …
View article: Changes in plasma concentration of flavonoids after ingestion of a flavonoid-rich meal prepared with basic foodstuffs
Changes in plasma concentration of flavonoids after ingestion of a flavonoid-rich meal prepared with basic foodstuffs Open
Background: As flavonoids have a variety of functions, such as antioxidant activity, there is growing interest in the development of flavonoid supplements. However, there have been reports of DNA damage due to exposure to flavonoids at hig…
View article: Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin
Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin Open
Previously, we reported that the frequency of micronucleated reticulocytes (MNRETs) in the peripheral blood of male C3H/He mice intraperitoneally administered ethylnitrosourea (ENU) (25 mg/kg body weight) in the dark period (zeitgeber time…
View article: Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-<i>Lepr<sup>fa</sup></i> (SDT fatty) rats
Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-<i>Lepr<sup>fa</sup></i> (SDT fatty) rats Open
In order to estimate the potential risk of chemicals including drug in patients with type 2 diabetes mellitus (T2DM), we investigated allyl alcohol induced liver injury using SD rats and Spontaneously Diabetic Torii-Leprfa (SDT …
View article: Carbamazepine-induced liver injury using type 2 diabetes Spontaneously Diabetic Torii-<i>Lepr<sup>fa</sup></i> (SDT fatty) rats as a model for human type 2 diabetes
Carbamazepine-induced liver injury using type 2 diabetes Spontaneously Diabetic Torii-<i>Lepr<sup>fa</sup></i> (SDT fatty) rats as a model for human type 2 diabetes Open
The diabetic state is considered to be one of the risk factors of drug-induced liver injury (DILI) because of the lower levels of glutathione for detoxification by conjugation with drugs. Carbamazepine (CBZ) -induced hepatotoxicity in huma…
View article: Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice
Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice Open
Background: Alpha monoglucosyl-rutin (4G-α-D-glucopyranosyl rutin, αMR) has been shown to stimulate antioxidant defenses and anti-glycation. We evaluated the effects of αMR on body weight gain in mice.Methods: Male C57BL/6J mice were divid…
View article: Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice
Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice Open
View article: Adsorptive Property of Food Materials and Chemicals to Cesium and Strontium
Adsorptive Property of Food Materials and Chemicals to Cesium and Strontium Open
In March, 2011, large amounts of radioactive materials were released from the Fukushima Daiichi nuclear power plant after the nuclear accident. Especially, for humans, internal exposure to 137 Cs and 90 Sr radionuclides presents very high …
View article: Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid
Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid Open
View article: Effects of environmental and social stressors on biological rhythms
Effects of environmental and social stressors on biological rhythms Open
Life in contemporary society is increasingly stressful, and the body is unconsciously exposed to various stressors involving physical, biological, chemical, and social/psychological factors. Exposure to these stressors causes definite biol…
View article: Exploration of food materials and components showing the suppressing effect on absorption of strontium and the promoting effect on excretion of cesium in vivo
Exploration of food materials and components showing the suppressing effect on absorption of strontium and the promoting effect on excretion of cesium in vivo Open
Strontium, which is classified as an alkaline earth metal in the periodic table, can chemically replace calcium in the bone and remain there for a long time [7].Therefore, internal radiation exposure, depending on intake of foods contamina…