Kazuhide Inage
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View article: Bone morphogenetic protein-2-independent bone formation by human iPSC-derived megakaryocytes and platelets
Bone morphogenetic protein-2-independent bone formation by human iPSC-derived megakaryocytes and platelets Open
Bone regeneration (BR) is an ongoing challenge in biomedical research. While recombinant human bone morphogenetic protein-2 (rhBMP-2) is available for clinical use, its side effects remain a concern. Patient-derived platelet-rich plasma ha…
View article: Comparison of Three Evaluation Methods for the Lumbar Intervertebral Disc Vacuum Phenomenon in Predicting Postoperative Residual Lower Back Pain
Comparison of Three Evaluation Methods for the Lumbar Intervertebral Disc Vacuum Phenomenon in Predicting Postoperative Residual Lower Back Pain Open
Evaluation of VP severity based on VP size (modified Willhuber's classification, SVP2) demonstrated the highest numerical predictive accuracy for postoperative residual LBP, but differences compared with other methods were not statisticall…
View article: Fresh Platelet-Rich Plasma Gel Reduces Sciatic Nerve-Associated Neuropathic Pain in Rats by Suppressing Tumor Necrosis Factor-α and Interleukin-6 Expression
Fresh Platelet-Rich Plasma Gel Reduces Sciatic Nerve-Associated Neuropathic Pain in Rats by Suppressing Tumor Necrosis Factor-α and Interleukin-6 Expression Open
PRP gel wrapping has a substantial long-term suppression effect on neuropathic pain, possibly involving suppression of Tnf-α and Il-6 expression in the nerves. This study suggests that PRP gel wrapping may be clinically appli…
View article: Feasibility of Ipsilateral Revision Oblique Lateral Interbody Fusion for Adjacent Segment Disease After Primary Oblique Lateral Interbody Fusion: A Retrospective Case Series
Feasibility of Ipsilateral Revision Oblique Lateral Interbody Fusion for Adjacent Segment Disease After Primary Oblique Lateral Interbody Fusion: A Retrospective Case Series Open
View article: Current status of patients with hip fracture in Japan: A nationwide survey
Current status of patients with hip fracture in Japan: A nationwide survey Open
Osteoporosis treatment rates after hip fractures remain low, indicating the need for more proactive intervention, including secondary fracture prevention. This study also highlights the importance of early rehabilitation and continuous sup…
View article: Mechanical Analysis of Romosozumab's Effects on Bone Strength in a Rat Posterolateral Lumbar Fusion Model
Mechanical Analysis of Romosozumab's Effects on Bone Strength in a Rat Posterolateral Lumbar Fusion Model Open
Romosozumab treatment significantly improved bone healing, mineral density, and mechanical strength in a rat PLF model, suggesting its potential as a therapeutic option for enhancing spinal surgery outcomes. By promoting rapid bone formati…
View article: A Study on Subjective Symptoms and Plantar Temperature Imbalance in Lumbar Spinal Stenosis: A Preliminary Study
A Study on Subjective Symptoms and Plantar Temperature Imbalance in Lumbar Spinal Stenosis: A Preliminary Study Open
View article: Quantitative assessment of lumbar dural mater pulsations using granger causality testing for spinal dynamics
Quantitative assessment of lumbar dural mater pulsations using granger causality testing for spinal dynamics Open
View article: Machine learning algorithms for predicting future curve using first and second visit data in female adolescent idiopathic scoliosis patients
Machine learning algorithms for predicting future curve using first and second visit data in female adolescent idiopathic scoliosis patients Open
Purpose This study was designed to develop a machine learning (ML) model that predicts future Cobb angle in patients with adolescent idiopathic scoliosis (AIS) using minimal radiographs and simple questionnaires during the first and second…
View article: Tumor Necrosis Factor-Alpha (TNF-α) and Interleukin-6 (IL-6) Cytokines in the Injured Meniscus of Patients With Knee Subchondral Insufficiency Fractures: A Potential Association With Preoperative Pain
Tumor Necrosis Factor-Alpha (TNF-α) and Interleukin-6 (IL-6) Cytokines in the Injured Meniscus of Patients With Knee Subchondral Insufficiency Fractures: A Potential Association With Preoperative Pain Open
View article: Efficacy and Limitations of Continuous Local Antibiotic Perfusion in Treating Surgical Site Infections Following Instrumented Spinal Surgery: A Retrospective Multicenter Study
Efficacy and Limitations of Continuous Local Antibiotic Perfusion in Treating Surgical Site Infections Following Instrumented Spinal Surgery: A Retrospective Multicenter Study Open
Application of CLAP enabled SSI control with a high rate of implant retention. However, detection of antibiotic-resistant pathogens and increased WBC count 1 week after initiating CLAP may predict poor control of SSI, even after CLAP.
View article: Utilizing Lower Limb Phase Angle as a Functional Prognostic Indicator for Patients in Convalescent Rehabilitation Wards
Utilizing Lower Limb Phase Angle as a Functional Prognostic Indicator for Patients in Convalescent Rehabilitation Wards Open
: LL-PA at admission is a significant predictor of functional outcomes in patients undergoing rehabilitation, with potential utility in early prognostic assessments.
View article: Prognostic Accuracy of Eight Scoring Systems in Untreated Patients with Spinal Metastases: A Comparative Study
Prognostic Accuracy of Eight Scoring Systems in Untreated Patients with Spinal Metastases: A Comparative Study Open
View article: Efficacy and Predictive Factors of Systemically Acting Diclofenac Sodium Patch for Chronic Low Back Pain: A Retrospective Observational Study
Efficacy and Predictive Factors of Systemically Acting Diclofenac Sodium Patch for Chronic Low Back Pain: A Retrospective Observational Study Open
View article: Predictive Factors for Increased Bone Density Following Romosozumab Administration Based on Pre-Administration Blood Test Results
Predictive Factors for Increased Bone Density Following Romosozumab Administration Based on Pre-Administration Blood Test Results Open
Romosozumab administration significantly increases bone density in osteoporosis, and assessing key predictive factors is necessary to ensure clinical effectiveness.
View article: The Analgesic and Side Effects of Tramadol Hydrochloride Immediate-Release and Extended-Release Tablets in Patients With Chronic Low Back Pain
The Analgesic and Side Effects of Tramadol Hydrochloride Immediate-Release and Extended-Release Tablets in Patients With Chronic Low Back Pain Open
This study shows the incidence of side effects following the administration of tramadol hydrochloride immediate-release and extended-release tablets. Regarding the breakdown of side effects, constipation, nausea, drowsiness, and dizziness …
View article: Evaluating the Correlation between Eyeglass-Type Wearable Device Measurements and Subjective Physical Activity Assessments
Evaluating the Correlation between Eyeglass-Type Wearable Device Measurements and Subjective Physical Activity Assessments Open
View article: P41. Muscle strength but not muscle mass might be associated with spinal sagittal alignment and low back pain in patients with osteoporosis
P41. Muscle strength but not muscle mass might be associated with spinal sagittal alignment and low back pain in patients with osteoporosis Open
View article: P13. Efficacy and limitations of continuous local antibiotic perfusion for patients with surgical site infection after instrumented spinal surgery; a retrospective multicenter study
P13. Efficacy and limitations of continuous local antibiotic perfusion for patients with surgical site infection after instrumented spinal surgery; a retrospective multicenter study Open
View article: Alterations in DNA methylation machinery in a rat model of osteoarthritis of the hip
Alterations in DNA methylation machinery in a rat model of osteoarthritis of the hip Open
Background This study aimed to validate alterations in the gene expression of DNA methylation-related enzymes and global methylation in the peripheral blood mononuclear cell (PBMC) and synovial tissues of animal hip osteoarthritis (OA) mod…
View article: Intervertebral Disc Degeneration in Long-Term Postoperative Patients with Adolescent Idiopathic Scoliosis: MRI Evaluation 34-51 Years after Surgery and its Changes during Middle and Older Age for an Average of 6.9 Years
Intervertebral Disc Degeneration in Long-Term Postoperative Patients with Adolescent Idiopathic Scoliosis: MRI Evaluation 34-51 Years after Surgery and its Changes during Middle and Older Age for an Average of 6.9 Years Open
This study suggests that maintaining the LIV at L3 or higher, achieving good sagittal alignment, and maintaining LL may help prevent long-term DD in AIS patients.
View article: Osteogenic effects and safety of human induced pluripotent stem cell-derived megakaryocytes and platelets produced on a clinical scale
Osteogenic effects and safety of human induced pluripotent stem cell-derived megakaryocytes and platelets produced on a clinical scale Open
View article: Retroperitoneal continuous local antibiotic perfusion for surgical site infection after lumbar lateral interbody fusion: A case report
Retroperitoneal continuous local antibiotic perfusion for surgical site infection after lumbar lateral interbody fusion: A case report Open
Surgical site infection (SSI) after instrumented spinal surgery (ISS) is one of the most serious surgical complications. Treatment is often difficult, with many cases requiring removal of the implant. An 80-year-old man developed refractor…
View article: Conversion of T2-Weighted Magnetic Resonance Images of Cervical Spine Trauma to Short T1 Inversion Recovery (STIR) Images by Generative Adversarial Network
Conversion of T2-Weighted Magnetic Resonance Images of Cervical Spine Trauma to Short T1 Inversion Recovery (STIR) Images by Generative Adversarial Network Open
The GAN model can generate synthetic STIRs from T2 images of cervical spine trauma using image-to-image conversion techniques. The use of a combination of synthetic STIR images generated by a GAN and T2WI improves sensitivity in detecting …
View article: A Novel Evaluation for Vertebral Artery Course Using 3D Magnetic Resonance Imaging with Computed Tomography -like Bone Contrast and Magnetic Resonance Angiography: A Proof of Concept Study
A Novel Evaluation for Vertebral Artery Course Using 3D Magnetic Resonance Imaging with Computed Tomography -like Bone Contrast and Magnetic Resonance Angiography: A Proof of Concept Study Open
The integration of the FRACTURE sequence and TOF MRA presents a promising methodology for the precise evaluation of VA courses in the cervical spine. This approach improves preoperative planning for cervical spine surgery with detailed ana…
View article: Association of Spinal Corrective Surgery With Abdominal Aorta Length in Patients With Adult Spinal Deformity
Association of Spinal Corrective Surgery With Abdominal Aorta Length in Patients With Adult Spinal Deformity Open
View article: Association between Osteoporosis and Skeletal Muscle Mass in Men
Association between Osteoporosis and Skeletal Muscle Mass in Men Open
Study Design: Cross-sectional study.Purpose: This cross-sectional study aimed to investigate the risk factors for osteoporosis in men by assessing bone mineral density (BMD), skeletal muscle mass, body fat mass, grip strength, and advanced…
View article: Machine Learning and Deep Learning in Spinal Injury: A Narrative Review of Algorithms in Diagnosis and Prognosis
Machine Learning and Deep Learning in Spinal Injury: A Narrative Review of Algorithms in Diagnosis and Prognosis Open
Spinal injuries, including cervical and thoracolumbar fractures, continue to be a major public health concern. Recent advancements in machine learning and deep learning technologies offer exciting prospects for improving both diagnostic an…
View article: Retroperitoneal Continuous Local Antibiotic Perfusion for Refractory Pyogenic Vertebral Osteomyelitis: A Case Report
Retroperitoneal Continuous Local Antibiotic Perfusion for Refractory Pyogenic Vertebral Osteomyelitis: A Case Report Open
Pyogenic vertebral osteomyelitis (PVO) is a prevalent infection in the elderly, frequently complicated by iliopsoas and epidural abscesses. Traditional treatments are often ineffective for refractory cases. In this report, a 76-year-old ma…
View article: Retroperitoneal Continuous Local Antibiotic Perfusion for Refractory Pyogenic Vertebral Osteomyelitis: A Case Report
Retroperitoneal Continuous Local Antibiotic Perfusion for Refractory Pyogenic Vertebral Osteomyelitis: A Case Report Open
Pyogenic vertebral osteomyelitis (PVO) is a prevalent infection in the elderly, frequently complicated by iliopsoas and epidural abscesses. Traditional treatments are often ineffective for refractory cases. In this report, a 76-year-old ma…