Kazuhiro Daino
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View article: Influence of age and sex on the relative biological effectiveness of 13-keV/μm carbon ions for lifespan shortening of B6C3F1 Mice
Influence of age and sex on the relative biological effectiveness of 13-keV/μm carbon ions for lifespan shortening of B6C3F1 Mice Open
Epidemiological studies of Japanese atomic bomb survivors indicate that the risk of cancer from radiation exposure is higher in individuals who are relatively young at the time of exposure, with women facing a more significant risk compare…
View article: Mutational Signatures in Radiation-Induced Cancer: A Review of Experimental Animal and Human Studies
Mutational Signatures in Radiation-Induced Cancer: A Review of Experimental Animal and Human Studies Open
Ionizing radiation can damage DNA, leading to mutations, and is a risk factor for cancer. Based on the assumption that all radiation exposure poses a risk in linear proportion to its dose, ionizing radiation is considered a non-threshold c…
View article: Luminal progenitor and mature cells are more susceptible than basal cells to radiation-induced DNA double-strand breaks in rat mammary tissue
Luminal progenitor and mature cells are more susceptible than basal cells to radiation-induced DNA double-strand breaks in rat mammary tissue Open
Ionizing radiation promotes mammary carcinogenesis. Induction of DNA double-strand breaks (DSBs) is the initial event after radiation exposure, which can potentially lead to carcinogenesis, but the dynamics of DSB induction and repair are …
View article: <i>Rev1</i> overexpression accelerates <i>N</i>‐methyl‐<i>N</i>‐nitrosourea (MNU)‐induced thymic lymphoma by increasing mutagenesis
<i>Rev1</i> overexpression accelerates <i>N</i>‐methyl‐<i>N</i>‐nitrosourea (MNU)‐induced thymic lymphoma by increasing mutagenesis Open
Rev1 has two important functions in the translesion synthesis pathway, including dCMP transferase activity, and acts as a scaffolding protein for other polymerases involved in translesion synthesis. However, the role of Rev1 in mutagenesis…
View article: Newly discovered genomic mutation patterns in radiation-induced small intestinal tumors of ApcMin/+ mice
Newly discovered genomic mutation patterns in radiation-induced small intestinal tumors of ApcMin/+ mice Open
Among the small intestinal tumors that occur in irradiated mice of the established mouse model B6/B6-Chr18 MSM -F1 Apc Min/+ , loss of heterozygosity analysis can be utilized to estimate whether a deletion in the wild-type allele containin…
View article: Interstitial deletion of the <i>Apc</i> locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 <i>ApcMin</i>/+ mice
Interstitial deletion of the <i>Apc</i> locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 <i>ApcMin</i>/+ mice Open
Recent studies have identified interstitial deletions in the cancer genome as a radiation-related mutational signature, although most of them do not fall on cancer driver genes. Pioneering studies in the field have indicated the presence o…
View article: Calorie restriction alters the mechanisms of radiation-induced mouse thymic lymphomagenesis
Calorie restriction alters the mechanisms of radiation-induced mouse thymic lymphomagenesis Open
Calorie restriction (CR) suppresses not only spontaneous but also chemical- and radiation-induced carcinogenesis. Our previous study revealed that the cancer-preventive effect of CR is tissue dependent and that CR does not effectively prev…
View article: Modifiers of radiation effects on breast cancer incidence revealed by a reanalysis of archival data of rat experiments
Modifiers of radiation effects on breast cancer incidence revealed by a reanalysis of archival data of rat experiments Open
Cancer risk after exposure to ionizing radiation can vary between individuals and populations, but the impact of factors governing those variations is not well understood. We previously conducted a series of carcinogenesis experiments usin…
View article: <scp><i>Brca1</i><sup>L63X</sup></scp><sup>/+</sup> rat is a novel model of human <i>BRCA1</i> deficiency displaying susceptibility to radiation‐induced mammary cancer
<span><i>Brca1</i><sup>L63X</sup></span><sup>/+</sup> rat is a novel model of human <i>BRCA1</i> deficiency displaying susceptibility to radiation‐induced mammary cancer Open
Women who are heterozygous for deleterious BRCA1 germline mutations harbor a high risk of hereditary breast cancer. Previous Brca1 ‐heterozygous animal models do not recapitulate the breast cancer phenotype, and thus all currently used kno…
View article: Development of mammary cancer in γ-irradiated F1 hybrids of susceptible Sprague-Dawley and resistant Copenhagen rats, with copy-number losses that pinpoint potential tumor suppressors
Development of mammary cancer in γ-irradiated F1 hybrids of susceptible Sprague-Dawley and resistant Copenhagen rats, with copy-number losses that pinpoint potential tumor suppressors Open
Copenhagen rats are highly resistant to mammary carcinogenesis, even after treatment with chemical carcinogens and hormones; most studies indicate that this is a dominant genetic trait. To test whether this trait is also dominant after rad…
View article: Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation
Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation Open
Epidemiological studies of atomic-bomb survivors have revealed an increased risk of lymphoid neoplasm (i.e. acute lymphoblastic leukemia) associated with radiation exposure. In particular, children are more susceptible to radiation-induced…
View article: Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation‐associated renal tumors in Eker rats
Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation‐associated renal tumors in Eker rats Open
Ionizing radiation can damage DNA and, therefore, is a risk factor for cancer. Eker rats, which carry a heterozygous germline mutation in the tumor‐suppressor gene tuberous sclerosis complex 2 ( Tsc2 ), are susceptible to radiation‐induced…
View article: 8.2.8 Effect of carbon ions on carcinogenesis
8.2.8 Effect of carbon ions on carcinogenesis Open
HIMACを用いて行われた動物発がん実験について，RBEに関する知見を中心に概説する。重粒子線治療の二次がんリスクを予測するに当たっては，炭素線の発がんに関する生物学的効果比（RBE）の選択に不確実性がある。そこで，HIMACを用いていくつかの動物発がん実験が行われたが，その結果から，RBEが組織，年齢，線量に依存した値をとることが示唆されている。今後，全身の臓器を観察するなどのより包括的な研究が必要である。
View article: Neutron-induced Rat Mammary Carcinomas Are Mainly of Luminal Subtype and Have Multiple Copy Number Aberrations
Neutron-induced Rat Mammary Carcinomas Are Mainly of Luminal Subtype and Have Multiple Copy Number Aberrations Open
Neutrons and γ rays increase the incidence of luminal mammary carcinoma in rats, probably via genetic aberrations similar to those found in human breast cancer patients.
View article: Differential effect of parity on rat mammary carcinogenesis after pre- or post-pubertal exposure to radiation
Differential effect of parity on rat mammary carcinogenesis after pre- or post-pubertal exposure to radiation Open
View article: PO-118 Impact of parity on neutron-induced mammary cancer risk in sprague-dawley rats
PO-118 Impact of parity on neutron-induced mammary cancer risk in sprague-dawley rats Open
Introduction Breast cancer is one of the most common cancers in women throughout the world. It is well known that ionising radiation is a potent carcinogen of breast, and its effect is modified by both age at its exposure and the reproduc…
View article: Epigenetic dysregulation of key developmental genes in radiation‐induced rat mammary carcinomas
Epigenetic dysregulation of key developmental genes in radiation‐induced rat mammary carcinomas Open
With the increase in the number of long‐term cancer survivors worldwide, there is a growing concern about the risk of secondary cancers induced by radiotherapy. Epigenetic modifications of genes associated with carcinogenesis are attractiv…
View article: Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas
Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas Open
The PI3K/AKT pathway is one of the most important signaling networks in human breast cancer, and since it was potentially implicated in our preliminary investigations of radiation-induced rat mammary carcinomas, our aim here was to verify …
View article: DNA Methylation Patterns in Rat Mammary Carcinomas Induced by Pre- and Post-Pubertal Irradiation
DNA Methylation Patterns in Rat Mammary Carcinomas Induced by Pre- and Post-Pubertal Irradiation Open
Several lines of evidence indicate one's age at exposure to radiation strongly modifies the risk of radiation-induced breast cancer. We previously reported that rat mammary carcinomas induced by pre- and post-pubertal irradiation have dist…
View article: Transcriptomic Signatures of Auger Electron Radioimmunotherapy Using Nuclear Targeting <sup>111</sup>In-Trastuzumab for Potential Combination Therapies
Transcriptomic Signatures of Auger Electron Radioimmunotherapy Using Nuclear Targeting <sup>111</sup>In-Trastuzumab for Potential Combination Therapies Open
(111)In-labeled trastuzumab modified with nuclear localizing signal (NLS) peptides ((111)In-trastuzumab-NLS) efficiently delivers an Auger electron (AE) emitter (111)In into the cell nucleus and is thus a promising radiopharmaceutical in A…