Kosuke Sasaki
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View article: Observational Study on Actual Cancer Screening Participation and Outcomes Among Patients with Lung Cancer Based on Linkage of Cancer Registry and Kyoto City Integrated Database Data from 2014 to 2018
Observational Study on Actual Cancer Screening Participation and Outcomes Among Patients with Lung Cancer Based on Linkage of Cancer Registry and Kyoto City Integrated Database Data from 2014 to 2018 Open
Background: Lung cancer is a major cause of death. Japan has a higher rate of early detection of lung cancer, which is attributed to the impact of chest X-ray examinations implemented as mass screening. This study describes the characteris…
View article: A case report: The cerebral metabolic rate of oxygen evaluated by 15O positron emission tomography may predict the recovery of cortical deafness due to bilateral cerebral hemorrhage
A case report: The cerebral metabolic rate of oxygen evaluated by 15O positron emission tomography may predict the recovery of cortical deafness due to bilateral cerebral hemorrhage Open
Cortical deafness is a rare central auditory disorder resulting in severe hearing loss. It is caused by bilateral damage to the auditory cortex, auditory radiation, or medial geniculate body. We herein report a case of cortical deafness re…
View article: Concept and feasibility of solar indirect heating plant in batch-wise processing for thermochemical CO2 splitting via tubular furnace experiment and reacting heat transfer simulation
Concept and feasibility of solar indirect heating plant in batch-wise processing for thermochemical CO2 splitting via tubular furnace experiment and reacting heat transfer simulation Open
View article: Characteristics of Cerebral Infarction Due to Anterior Cerebral Artery Dissection: A Review of 16 Cases
Characteristics of Cerebral Infarction Due to Anterior Cerebral Artery Dissection: A Review of 16 Cases Open
View article: MECHANISM OF DEVELOPMENT OF GROUND DAMAGE AFFECTING SAND BOILS BEHAVIORS IN THE INSIDE AREA OF RIVER LEVEE
MECHANISM OF DEVELOPMENT OF GROUND DAMAGE AFFECTING SAND BOILS BEHAVIORS IN THE INSIDE AREA OF RIVER LEVEE Open
View article: Carotid artery stent for carotid web that underwent dynamic morphological changes in a short time
Carotid artery stent for carotid web that underwent dynamic morphological changes in a short time Open
View article: Estimation of the rupture point of the craniovertebral junction intradural arteriovenous fistula with vessel wall magnetic resonance image and its pathological findings: A case report
Estimation of the rupture point of the craniovertebral junction intradural arteriovenous fistula with vessel wall magnetic resonance image and its pathological findings: A case report Open
Background: Arteriovenous fistulas (AVFs) of the craniocervical junction (CCJ) and intradural AVFs are often associated with aneurysms and varics, and it is sometimes difficult to identify the ruptured point on radiological images. We repo…
View article: A Japanese Boy With Spotted Fever and Overlapping Symptoms of Kawasaki Disease: A Case Report
A Japanese Boy With Spotted Fever and Overlapping Symptoms of Kawasaki Disease: A Case Report Open
Japanese spotted fever (JSF) is a tick-transmitted infection caused by Rickettsia japonica (R. japonica), which is indigenous to Japan. Patients with JSF typically present with fever and spotted erythema on the palms and/or s…
View article: Intracranial parenchymal capillary hemangioma: A case report
Intracranial parenchymal capillary hemangioma: A case report Open
Background: Capillary hemangioma is a rare benign hemangioma that occurs in the soft tissues of the skin, orbit, head, and neck. Intracranial cases, especially intraparenchymal cases, are extremely rare. In this study, we report the course…
View article: Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database
Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database Open
Background Lung cancer is the primary cause of cancer mortality and non‐small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. New drug treatments have been developed since 2010 but there are concerns about the incr…
View article: Prealbumin level is a predictor of activities of daily living at discharge in older patients with heart failure who became ADL-independent after hospitalization - Acute and early recovery cardiac rehabilitation trials
Prealbumin level is a predictor of activities of daily living at discharge in older patients with heart failure who became ADL-independent after hospitalization - Acute and early recovery cardiac rehabilitation trials Open
Prealbumin levels are useful in predicting discharge BI in older patients with HF who become non-independent in ADL after hospitalization.
View article: Physical performance and maximum tongue pressure associated with oral intake independence: a retrospective study on hospitalized patients with heart failure
Physical performance and maximum tongue pressure associated with oral intake independence: a retrospective study on hospitalized patients with heart failure Open
View article: mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy
mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy Open
Dendritic cells (DCs) are attractive antigen-presenting cells to be targeted for vaccinations. However, the systemic delivery of mRNA to DCs is hampered by technical challenges. We recently reported that it is possible to regulate the size…
View article: First web space plasty using Ilizarov mini fixator in patients with complex hand injuries
First web space plasty using Ilizarov mini fixator in patients with complex hand injuries Open
Background Effective treatment and rehabilitation of complex hand injuries are often challenging. Various corrective techniques and approaches have been proposed for the first web space contractures based on a classification system, howeve…
View article: Temporal Trend in an Initial Treatment, Survival, and Medical Costs Among Patients With Lung Cancer Between 2013 and 2018 in Kyoto City, Japan
Temporal Trend in an Initial Treatment, Survival, and Medical Costs Among Patients With Lung Cancer Between 2013 and 2018 in Kyoto City, Japan Open
This cross-sectional study demonstrated that the improvement in the survival rate and proportion of surgery as an initial treatment was increased whereas drug therapy decreased and medical costs increased among patients with lung cancer ov…
View article: On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device
On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device Open
View article: C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer
C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer Open
View article: Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer
Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer Open
View article: Multimaterial decomposition algorithm for quantification of fat in hepatocellular carcinoma using rapid kilovoltage-switching dual-energy CT
Multimaterial decomposition algorithm for quantification of fat in hepatocellular carcinoma using rapid kilovoltage-switching dual-energy CT Open
Understanding intratumoral fat in hepatocellular carcinoma (HCC) is clinically important to elucidate prognosis. We sought to quantify HCC and liver fat with a multimaterial decomposition (MMD) algorithm with rapid kilovoltage-switching du…
View article: Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications
Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications Open
Dual-energy computed tomography (DECT) is an imaging technique based on data acquisition at two different energy settings. Recent advances in CT have allowed data acquisitions and simultaneous analyses of X-rays at two energy levels, and h…
View article: Three-dimensional, symmetrically assembled microfluidic device for lipid nanoparticle production
Three-dimensional, symmetrically assembled microfluidic device for lipid nanoparticle production Open
We developed a three-dimensional and symmetrically assembled microfluidic device named the 3D-iLiNP device. The 3D-iLiNP device allowed the precise size control of sub-100 nm sized lipid nanoparticles by the homogeneous and slow ethanol di…
View article: Fucosylated C4b‑binding protein α‑chain, a novel serum biomarker that predicts lymph node metastasis in pancreatic ductal adenocarcinoma
Fucosylated C4b‑binding protein α‑chain, a novel serum biomarker that predicts lymph node metastasis in pancreatic ductal adenocarcinoma Open
C4b-binding protein α-chain (C4BPA) was previously identified as a novel serum biomarker for pancreatic ductal adenocarcinoma (PDAC). To apply this biomarker for clinical diagnosis, a lectin ELISA was established to measure serum fucosylat…
View article: Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus
Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus Open
View article: Effectiveness of ultrasonographic evaluation under general anesthesia for radial nerve palsy associated with humeral fractures during the first operation
Effectiveness of ultrasonographic evaluation under general anesthesia for radial nerve palsy associated with humeral fractures during the first operation Open
View article: Ischemic gastropathy after distal pancreatectomy with en bloc celiac axis resection versus distal pancreatectomy for pancreatic body/tail cancer
Ischemic gastropathy after distal pancreatectomy with en bloc celiac axis resection versus distal pancreatectomy for pancreatic body/tail cancer Open
View article: Evaluation of intramedullary nail fixation via the Neviaser portal for proximal humerus fracture
Evaluation of intramedullary nail fixation via the Neviaser portal for proximal humerus fracture Open
View article: Posterior interosseous nerve palsy caused by synovial osteochondromatosis of the elbow analyzed by three-dimensional reconstruction: a case report
Posterior interosseous nerve palsy caused by synovial osteochondromatosis of the elbow analyzed by three-dimensional reconstruction: a case report Open
View article: Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na<sub>V</sub>1.7
Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na<sub>V</sub>1.7 Open
A series of acidic diaryl ether heterocyclic sulfonamides that are potent and subtype selective NaV1.7 inhibitors is described. Optimization of early lead matter focused on removal of structural alerts, improving metabolic stabi…
View article: Two Cases of Hiatal Hernia after Esophagectomy with Gastric Tube Reconstruction via Posterior Mediastinal Route
Two Cases of Hiatal Hernia after Esophagectomy with Gastric Tube Reconstruction via Posterior Mediastinal Route Open
症例1は76歳の男性で,8年前に右開胸開腹食道亜全摘,後縦隔経路胃管再建の既往がある.腹痛・嘔吐を主訴に救急外来受診し,画像検査で食道裂孔より右胸腔内に腸管の脱出を認めた.緊急手術で食道裂孔の縫縮を行った.術後第9病日に軽快退院した.症例2は67歳の男性で,3年前に咽喉頭全摘,非開胸食道抜去術,後縦隔経路胃管再建の既往がある.腹痛を主訴に救急外来受診し,画像検査では左胸腔内に腸管の脱出を認めた.緊急手術で食道裂孔の縫縮を行い,術後第14病日に軽快退院した.食道癌術後の横隔膜…
View article: Cervical Spinal Extradural Hematoma Secondary to Epidural Arteriovenous Malformation
Cervical Spinal Extradural Hematoma Secondary to Epidural Arteriovenous Malformation Open
Reports on the etiology of cervical spinal extradural hematoma secondary to epidural arteriovenous malformation (AVM) are comparatively few. We report here the clinical course and treatment outcome in two such cases.