Explanipedia

Efficient gene disruption with CRISPR-Cas3 in human T cells Open

Tomoaki Fujii, Yukimi Sakoda, Kazuto Yoshimi, Kohei Takeshita, Kazumasa Yokoyama , et al. · 2025

Summary The CRISPR-Cas9 system has been widely adopted as a genome editing tool due to its high efficiency and versatility, contributing to the development of various therapeutic strategies. However, its clinical application remains limite…

Age-related neuroinflammation and exacerbated immune responses in PINK1 and PARK2 knockout mice with experimental autoimmune encephalomyelitis Open

Davide Cossu, Sachiko Noda, Shigeto Sato, Kazumasa Yokoyama, Yuji Tomizawa , et al. · 2025

Recent studies suggest that the E3 ubiquitin ligase PARKIN and PTEN-induced kinase 1 (PINK1) contribute to age-related immune regulation and neuroinflammation, though the precise mechanisms remain unclear. In this study, we induced active …

Impact of Epstein–Barr Virus Nuclear Antigen 1 on Neuroinflammation in PARK2 Knockout Mice Open

Davide Cossu, Yuji Tomizawa, Sachiko Noda, Eiichi Momotani, Tamami Sakanishi , et al. · 2024

This study aimed to explore the intricate relationship between mitochondrial dysfunction, infection, and neuroinflammation, focusing specifically on the impact of pathogenic epitopes of the Epstein–Barr Virus (EBV) nuclear antigen 1 (EBNA1…

Impact of Epstein-Barr Virus Nuclear Antigen 1 on Neuroinflammation in PARK2 Knockout Mice with Mitochondrial Dysfunction Open

Davide Cossu, Yuji Tomizawa, Sachiko Noda, Eiichi Momotani, Tamami Sakanishi , et al. · 2024

This study aimed to explore the intricate relationship between mitochondrial dysfunction, infections, and neuroinflammation, focusing specifically on the impact of pathogenic epitopes of Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA1) i…

Cross‐vendor multiparametric mapping of the human brain using <span>3D‐QALAS</span>: A multicenter and multivendor study Open

Shohei Fujita, Borjan Gagoski, Ken‐Pin Hwang, Akifumi Hagiwara, Marcel Warntjes , et al. · 2024

Purpose To evaluate a vendor‐agnostic multiparametric mapping scheme based on 3D quantification using an interleaved Look–Locker acquisition sequence with a T2 preparation pulse (3D‐QALAS) for whole‐brain T1, T2, and proton density (PD) ma…

Glymphatic System Dysfunction in Myelin Oligodendrocyte Glycoprotein Immunoglobulin G Antibody–Associated Disorders: Association with Clinical Disability Open

Akifumi Hagiwara, Yuji Tomizawa, Y. Hoshino, Kazumasa Yokoyama, Koji Kamagata , et al. · 2023

This study suggests that patients with MOGAD may have impaired glymphatic function, as measured by the ALPS index, which is associated with patient disability. Further study is warranted with a larger sample size.

Comparing clinical and imaging features of patients with MOG antibody-positivity and with and without oligoclonal bands Open

Yuji Tomizawa, Yasunobu Hoshino, Ryota Kamo, Davide Cossu, Kazumasa Yokoyama , et al. · 2023

Introduction Myelin-oligodendrocyte glycoprotein antibody (MOG)–associated disorder (MOGAD) is a recently identified immune-mediated inflammatory disorder of the central nervous system (CNS). The significance of oligoclonal bands (OCBs) is…

Mycobacterium avium subsp. paratuberculosis Antigens Elicit a Strong IgG4 Response in Patients with Multiple Sclerosis and Exacerbate Experimental Autoimmune Encephalomyelitis Open

Davide Cossu, Yuji Tomizawa, Kazumasa Yokoyama, Tamami Sakanishi, Eiichi Momotani , et al. · 2023

Neuroinflammation can be triggered by microbial products disrupting immune regulation. In this study, we investigated the levels of IgG1, IgG2, IgG3, and IgG4 subclasses against the heat shock protein (HSP)70533–545 peptide and lipopentape…

Bacillus Calmette–Guérin Tokyo-172 vaccine provides age-related neuroprotection in actively induced and spontaneous experimental autoimmune encephalomyelitis models Open

Davide Cossu, Kazumasa Yokoyama, Tamami Sakanishi, Leonardo A. Sechi, Nobutaka Hattori · 2023

Multiple sclerosis is the most common immune-mediated disorder affecting the central nervous system in young adults but still has no cure. Bacillus Calmette–Guérin (BCG) vaccine is reported to have non-specific anti-inflammatory effects an…

Two Elderly Men with Myasthenia Gravis during Androgen Deprivation Therapy for Prostate Cancer Open

Kazo Kanazawa, Yuji Tomizawa, Tatou Iseki, Kazumasa Yokoyama, Nobutaka Hattori · 2023

Myasthenia gravis (MG) development is female-dominant in younger patients and male-dominant in older patients. The reason for the sex-ratio inversion in elderly MG patients remains unclear. One possible explanation is the decrease in andro…

Supplementary Material for: Refractory intestinal Behçet-like disease associated with trisomy 8 myelodysplastic syndrome resolved by parenteral nutrition Open

Ryuichi Takahashi, Yasuo Matsubara, Satoshi Takahashi, Kazumasa Yokoyama, Ahyoung L.L. , et al. · 2023

Intestinal Behçet disease (BD), associated with myelodysplastic syndrome (MDS), is often refractory to treatment. An 80-year-old man with trisomy 8 MDS (refractory anemia) developed intermittent fever. Despite investigations to exclude inf…

Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice Open

Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi , et al. · 2022

Objective Recent research has shown that Parkin, an E3 ubiquitin ligase, modulates peripheral immune cells-mediated immunity during experimental autoimmune encephalomyelitis (EAE). Because the PTEN-induced putative kinase 1 (PINK1) protein…

Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome Open

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu , et al. · 2022

Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome Open

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu , et al. · 2022

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by specific social symptoms, restricted interests, stereotyped repetitive behaviors, and delayed language development. The 3q29 microdeletion (3q29del), a recur…

Microstructural white matter abnormalities in multiple sclerosis and neuromyelitis optica spectrum disorders: Evaluation by advanced diffusion imaging Open

Shimpei Kato, Akifumi Hagiwara, Kazumasa Yokoyama, Christina Andica, Yuji Tomizawa , et al. · 2022

FW imaging and NODDI were useful for identifying the etiology of neurodegeneration- and neuroinflammation-related microstructural changes in RRMS and NMOSD patients.

Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder Open

Yasunobu Hoshino, Daisuke Noto, Shuhei Sano, Yuji Tomizawa, Kazumasa Yokoyama , et al. · 2022

Improvement in the Symptoms and VEGF Levels after Resection of an Extrame Dullary Spinal Tumor and Additional Chemotherapy in a Patient with Multiple Myeloma Complicated with POEMS Syndrome Open

Mariko Sano, Tatou Iseki, Makoto Sasaki, Yutaka Tsukune, Hajime Yasuda , et al. · 2021

We herein report a case of multiple myeloma and polyneuropathy, organomegaly, endocrinopathy, myeloma protein, and skin changes (POEMS) syndrome. The patient experienced exacerbated gait disturbance due to weakness and numbness in the lowe…

Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis Open

Fumie Hayashi, Noriko Isobe, Davide Cossu, Kazumasa Yokoyama, Ayako Sakoda , et al. · 2021

Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study Open

Davide Cossu, Kazumasa Yokoyama, Leonardo A. Sechi, Nobutaka Hattori · 2021

Background Mitochondrial dysfunction has been suggested to play an important role in all stages of multiple sclerosis (MS). Objective To determine the expression of two mitophagy-related proteins, PTEN-induced kinase 1 (PINK1) and PARKIN, …

Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorders by multiparametric quantitative MRI using convolutional neural network Open

Akifumi Hagiwara, Yujiro Otsuka, Christina Andica, Shimpei Kato, Kazumasa Yokoyama , et al. · 2021

Multiple sclerosis and neuromyelitis optica spectrum disorders are both neuroinflammatory diseases and have overlapping clinical manifestations. We developed a convolutional neural network model that differentiates between the two based on…

3D Quantitative Synthetic MRI in the Evaluation of Multiple Sclerosis Lesions Open

Shohei Fujita, Kazumasa Yokoyama, Akifumi Hagiwara, Shimpei Kato, Christina Andica , et al. · 2021

Three-dimensional synthetic MR imaging could serve as an alternative to conventional MR imaging in evaluating MS with a reduced scan time.

Current and future strategies for burnout in Japanese neurologists Open

Takayoshi Shimohata, Makoto Kubo, Ikuko Aiba, Nobutaka Hattori, Kazuto Yoshida , et al. · 2021

To identify factors associated with burnout among Japanese physician and to use them in future measures, the Japanese Society of Neurology conducted a survey of neurologists on burnout using a web-based questionnaire in October 2019. A tot…

Burnout in Japanese neurologists: comparison of male and female physicians Open

Makoto Kubo, Ikuko Aiba, Takayoshi Shimohata, Nobutaka Hattori, Kazuto Yoshida , et al. · 2021

A questionnaire survey was conducted on 8,402 members of the Japanese Neurological Society to examine the current status and countermeasures for physician burnout, and 1,261 respondents (15.0%) responded. In this paper, we report the resul…

Accelerated Isotropic Multiparametric Imaging by High Spatial Resolution 3D-QALAS With Compressed Sensing Open

Shohei Fujita, Akifumi Hagiwara, Naoyuki Takei, Ken‐Pin Hwang, Issei Fukunaga , et al. · 2020

Objectives The aims of this study were to develop an accelerated multiparametric magnetic resonance imaging method based on 3D-quantification using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse (3D-QALAS) comb…

CD8+ T-cell encephalitis mimicking PRES in AIDS: a case report Open

Mayu Ishiguro, Yuji Ueno, Yuta Ishiguro, Masashi Takanashi, Kenji Murai , et al. · 2020

Author Correction: Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system Open

Davide Cossu, Kazumasa Yokoyama, Yuji Tomizawa, Eiichi Momotani, Nobutaka Hattori · 2020

Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis Open

Laetitia Saccenti, Akifumi Hagiwara, Christina Andica, Kazumasa Yokoyama, Shohei Fujita , et al. · 2020

Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been es…

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome Open

Masayuki Baba, Kazumasa Yokoyama, Kaoru Seiriki, Kensuke Matsumura, Momoka Kondo , et al. · 2020

The 3q29 microdeletion is a rare recurrent copy number variant (CNV) leading to an increased risk for neurodevelopmental disorders, such as intellectual disability and autism spectrum disorder (ASD), and a >40-fold increased risk for schiz…

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome Open

Masayuki Baba, Kazumasa Yokoyama, Kaoru Seiriki, Kensuke Matsumura, Momoka Kondo , et al. · 2020

The 3q29 microdeletion is a rare recurrent copy number variant (CNV) leading to an increased risk for neurodevelopmental disorders, such as intellectual disability and autism spectrum disorder (ASD), and a >40-fold increased risk for schiz…

Suitable indications of eculizumab for patients with refractory generalized myasthenia gravis Open

Munenori Oyama, Kensuke Okada, Masayuki Masuda, Yuko Shimizu, Kazumasa Yokoyama , et al. · 2020

Background: Eculizumab is a humanized monoclonal antibody that targets complement protein C5 and inhibits terminal complement-mediated damage at the neuromuscular junction. Recently, the REGAIN study showed that eculizumab was effective an…

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