Kazumoto Iijima
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View article: Rituximab-induced long-term remission in childhood-onset, uncomplicated, frequently relapsing or steroid-dependent nephrotic syndrome: a randomized, placebo-controlled trial and a follow-up study
Rituximab-induced long-term remission in childhood-onset, uncomplicated, frequently relapsing or steroid-dependent nephrotic syndrome: a randomized, placebo-controlled trial and a follow-up study Open
View article: Safety and efficacy of prednisolone, mizoribine and lisinopril combination therapy for severe childhood IgA Nephropathy
Safety and efficacy of prednisolone, mizoribine and lisinopril combination therapy for severe childhood IgA Nephropathy Open
Background Angiotensin-converting enzyme inhibitors such as lisinopril have long been used for childhood IgA Nephropathy (cIgAN). A two-year combined regimen including prednisolone + mizoribine + warfarin + dipyridamole was shown in our pr…
View article: Mechanisms of the Effects of Polyphenols on Diabetic Nephropathy
Mechanisms of the Effects of Polyphenols on Diabetic Nephropathy Open
Diabetic nephropathy is a major challenge in medicine. While a variety of mechanisms underlie the onset and progression of diabetic nephropathy, oxidative stress is critical because it promotes inflammation and creates a vicious cycle that…
View article: Co-localization of IgG with nephrin in immune-mediated idiopathic nephrotic syndrome
Co-localization of IgG with nephrin in immune-mediated idiopathic nephrotic syndrome Open
Background Increased serum anti-nephrin antibody titers and co-localization of nephrin and IgG in kidney tissues have been reported in minimal change disease (MCD) and post-transplant recurrent focal segmental glomerulosclerosis (FSGS). Th…
View article: 320. PRELIMINARY STUDY ON VISUOSPATIAL IMPAIRMENT EXAMINED BY EYE TRACKING IN PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER
320. PRELIMINARY STUDY ON VISUOSPATIAL IMPAIRMENT EXAMINED BY EYE TRACKING IN PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER Open
Background Obsessive-Compulsive Disorder (OCD) is characterized by persistent obsessions and compulsions that significantly impair daily functioning. Neuropsychological research in OCD has pointed out deficits in executive functions such a…
View article: Genetic aspects of pediatric nephrotic syndrome and anti-nephrin antibodies
Genetic aspects of pediatric nephrotic syndrome and anti-nephrin antibodies Open
View article: Augmented Intrarenal and Urinary Angiotensinogen in Diabetic Nephropathy: The Role of Isoflavones
Augmented Intrarenal and Urinary Angiotensinogen in Diabetic Nephropathy: The Role of Isoflavones Open
The circulating renin–angiotensin system (RAS) is an endocrine system with key functions in maintaining blood pressure, fluid volume, and electrolytes. The RAS in the kidney (intrarenal RAS) plays a critical role in the onset and progressi…
View article: Population pharmacokinetic analysis in children with different diseases treated with mycophenolate mofetil—Integrated analysis of clinical trials and real-world clinical data
Population pharmacokinetic analysis in children with different diseases treated with mycophenolate mofetil—Integrated analysis of clinical trials and real-world clinical data Open
An integrated population PK model of MPA was developed in children with the following conditions: post-solid organ transplantation, post-HSCTx, autoimmune disease, and nephrotic syndrome. Estimated parameters and parameter covariates were …
View article: In steroid-resistant nephrotic syndrome that meets the strict definition, monogenic variants are less common than expected
In steroid-resistant nephrotic syndrome that meets the strict definition, monogenic variants are less common than expected Open
View article: Clinical characteristics and outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulopathy in Japanese children
Clinical characteristics and outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulopathy in Japanese children Open
Background Membranoproliferative glomerulonephritis (MPGN) can be divided into immune-complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G), which includes dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). These conditions result …
View article: In steroid-resistant nephrotic syndrome that meets the strict definition, monogenic variants less common than previously reported
In steroid-resistant nephrotic syndrome that meets the strict definition, monogenic variants less common than previously reported Open
Background In patients with steroid-resistant nephrotic syndrome (SRNS), the presence of monogenic variants influences therapeutic strategies. Large cohort studies reported the detection of monogenic variants in approximately 30% of patien…
View article: Clinical characteristics and long-term outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulopathy in Japanese children
Clinical characteristics and long-term outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulopathy in Japanese children Open
Background Membranoproliferative glomerulonephritis (MPGN) can be divided into immune-complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G), which include dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), respectively. These condi…
View article: Corrigendum to “A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants.” Kidney Int. 2023;103:962–972
Corrigendum to “A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants.” Kidney Int. 2023;103:962–972 Open
View article: Newborn Screening for Spinal Muscular Atrophy: A 2.5-Year Experience in Hyogo Prefecture, Japan
Newborn Screening for Spinal Muscular Atrophy: A 2.5-Year Experience in Hyogo Prefecture, Japan Open
Newborn screening (NBS) for spinal muscular atrophy (SMA) is necessary, as favorable outcomes can be achieved by treatment with disease-modifying drugs in early infancy. Although SMA-NBS has been initiated in Japan, its clinical results ha…
View article: Rituximab in combination with cyclosporine and steroid pulse therapy for childhood-onset multidrug-resistant nephrotic syndrome: a multicenter single-arm clinical trial (JSKDC11 trial)
Rituximab in combination with cyclosporine and steroid pulse therapy for childhood-onset multidrug-resistant nephrotic syndrome: a multicenter single-arm clinical trial (JSKDC11 trial) Open
Background Only 80% of children with idiopathic nephrotic syndrome respond well to glucocorticoid therapy. Multidrug-resistant nephrotic syndrome (MRNS) is associated with a poor kidney prognosis. Several retrospective studies have identif…
View article: #3670 THE ROLE OF CALCINEURIN INHIBITORS IN MONOGENIC PEDIATRIC STEROID RESISTANT NEPHROTIC SYNDROME: A RETROSPECTIVE, MULTICENTER STUDY
#3670 THE ROLE OF CALCINEURIN INHIBITORS IN MONOGENIC PEDIATRIC STEROID RESISTANT NEPHROTIC SYNDROME: A RETROSPECTIVE, MULTICENTER STUDY Open
Background and Aims Response to calcineurin inhibitors (CNI) is associated with a significant improvement in long-term kidney survival of children with non-genetic steroid resistant nephrotic syndrome (SRNS). On the contrary, these agents …
View article: Anti-nephrin antibodies in idiopathic nephrotic syndrome in Japanese children
Anti-nephrin antibodies in idiopathic nephrotic syndrome in Japanese children Open
Background Many patients with childhood idiopathic nephrotic syndrome are steroid-sensitive. Several genome-wide association studies have suggested a polygenic contribution, particularly in the HLA DR/DQ region and a locus including nephri…
View article: Correction: Noguchi et al. PCR-Based Screening of Spinal Muscular Atrophy for Newborn Infants in Hyogo Prefecture, Japan. Genes 2022, 13, 2110
Correction: Noguchi et al. PCR-Based Screening of Spinal Muscular Atrophy for Newborn Infants in Hyogo Prefecture, Japan. Genes 2022, 13, 2110 Open
The authors wish to make the following correction to this paper [...]
View article: Corrigendum to “Detecting MUC1 Variants in Patients Clinicopathologically Diagnosed With Having Autosomal Dominant Tubulointerstitial Kidney Disease”Kidney International Reports, Volume 7, Issue 4, April 2022, Pages 857-866.
Corrigendum to “Detecting MUC1 Variants in Patients Clinicopathologically Diagnosed With Having Autosomal Dominant Tubulointerstitial Kidney Disease”Kidney International Reports, Volume 7, Issue 4, April 2022, Pages 857-866. Open
[This corrects the article DOI: 10.1016/j.ekir.2021.12.037.].
View article: A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants
A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants Open
View article: Physiologically‐based pharmacokinetic model to investigate the effect of pregnancy on risperidone and paliperidone pharmacokinetics: Application to a pregnant woman and her neonate
Physiologically‐based pharmacokinetic model to investigate the effect of pregnancy on risperidone and paliperidone pharmacokinetics: Application to a pregnant woman and her neonate Open
This study aimed to determine the effects of pregnancy and ontogeny on risperidone and paliperidone pharmacokinetics by assessing their serum concentrations in two subjects and constructing a customized physiologically‐based pharmacokineti…
View article: Time course of serum cytokine level changes within 72 h after onset in children with acute encephalopathy and febrile seizures
Time course of serum cytokine level changes within 72 h after onset in children with acute encephalopathy and febrile seizures Open
Background Cytokine levels have been measured in acute encephalopathy (AE) to determine its pathology or as a diagnostic biomarker to distinguish it from febrile seizures (FS); however, the dynamics of cytokine level changes have not yet b…
View article: Is influenza vaccination associated with nephrotic syndrome relapse in children? A multicenter prospective study
Is influenza vaccination associated with nephrotic syndrome relapse in children? A multicenter prospective study Open
View article: Effects of Bardoxolone Methyl in Alport Syndrome
Effects of Bardoxolone Methyl in Alport Syndrome Open
Background and objectives Alport syndrome is an inherited disease characterized by progressive loss of kidney function. We aimed to evaluate the safety and efficacy of bardoxolone methyl in patients with Alport syndrome. Design, setting, p…
View article: PCR-Based Screening of Spinal Muscular Atrophy for Newborn Infants in Hyogo Prefecture, Japan
PCR-Based Screening of Spinal Muscular Atrophy for Newborn Infants in Hyogo Prefecture, Japan Open
Spinal muscular atrophy (SMA) is a common devastating neuromuscular disorder, usually involving homozygous deletion of the SMN1 gene. Newly developed drugs can improve the motor functions of infants with SMA when treated in the early stage…
View article: Aberrant splicing caused by exonic single nucleotide variants positioned 2nd or 3rd to the last nucleotide in the COL4A5 gene
Aberrant splicing caused by exonic single nucleotide variants positioned 2nd or 3rd to the last nucleotide in the COL4A5 gene Open
View article: IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome
IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome Open
View article: A case of Potter sequence with WT1 mutation
A case of Potter sequence with WT1 mutation Open
View article: Multi-population genome-wide association study implicates both immune and non-immune factors in the etiology of pediatric steroid sensitive nephrotic syndrome
Multi-population genome-wide association study implicates both immune and non-immune factors in the etiology of pediatric steroid sensitive nephrotic syndrome Open
Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood glomerular disease. Previous genome-wide association studies (GWAS) identified a risk locus in the HLA Class II region and three additional signals. But th…
View article: Epidemiology of biopsy-proven Henoch–Schönlein purpura nephritis in children: A nationwide survey in Japan
Epidemiology of biopsy-proven Henoch–Schönlein purpura nephritis in children: A nationwide survey in Japan Open
Background Little is known about the epidemiology of Henoch–Schönlein purpura nephritis (HSPN). Methods We conducted a nationwide epidemiological survey of Japanese children aged 1 to 15 years with HSPN. Children who were newly diagnosed w…