Kazunari Kaneko
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View article: Depletion of gut microbiota alleviates proteinuria in puromycin aminonucleoside-induced nephrosis in rats
Depletion of gut microbiota alleviates proteinuria in puromycin aminonucleoside-induced nephrosis in rats Open
Background The gut–kidney axis has been implicated in chronic kidney disease, however its role in minimal change nephrotic syndrome (MCNS) is poorly understood. We investigated the impact of gut microbiota on proteinuria in MCNS. Methods A…
View article: Effect of Cranberry Juice Consumption on the Urobiome in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial
Effect of Cranberry Juice Consumption on the Urobiome in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Open
Purpose: Cranberry juice is widely consumed to improve urinary health; however, its effects on the urinary microbiome (urobiome) of healthy individuals are unclear. We aimed to investigate the effect of continuous consumption of cranberry …
View article: Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis
Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis Open
Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (Pol η) is most recognised for tolerating…
View article: Exercise training improves circulatory dynamics in adolescents with postural orthostatic tachycardia syndrome
Exercise training improves circulatory dynamics in adolescents with postural orthostatic tachycardia syndrome Open
Introduction Exercise training is recommended for PoTS; however, very few studies have examined the effectiveness of exercise training in young adolescents with PoTS. We evaluated the effects of ergometer endurance exercise on the circulat…
View article: Gut dysbiosis as a susceptibility factor in childhood idiopathic nephrotic syndrome
Gut dysbiosis as a susceptibility factor in childhood idiopathic nephrotic syndrome Open
Idiopathic nephrotic syndrome (INS) is a relatively common renal disorder of childhood characterized by severe proteinuria and associated hypoproteinemia and edema. Although the pathogenesis of INS remains unknown, the prevailing theory of…
View article: Coulomb Excitation of $^{80}$Sr and the limits of the $N = Z = 40$ island of deformation
Coulomb Excitation of $^{80}$Sr and the limits of the $N = Z = 40$ island of deformation Open
The region of $N\approx Z\approx 40$ has long been associated with strongly deformed nuclear configurations. The presence of this strong deformation was recently confirmed through lifetime measurements in $N\approx Z$ Sr and Zr nuclei. The…
View article: Dysbiosis of Urinary Microbiome (Urobiome) in Male Children With Nocturnal Enuresis
Dysbiosis of Urinary Microbiome (Urobiome) in Male Children With Nocturnal Enuresis Open
Purpose: To determine the characteristics of the urobiome in boys with nocturnal enuresis. Materials and Methods: We enrolled 25 boys aged 5 to 12 years with untreated nocturnal enuresis (nocturnal enuresis group; median age, 7.4 years) an…
View article: Citrin-deficient patient-derived induced pluripotent stem cells as a pathological liver model for congenital urea cycle disorders
Citrin-deficient patient-derived induced pluripotent stem cells as a pathological liver model for congenital urea cycle disorders Open
Citrin deficiency is a congenital secondary urea cycle disorder lacking useful disease models for effective treatment development. In this study, human induced pluripotent stem cells (iPSCs) were generated from two patients with citrin def…
View article: Platelet and white blood cell counts correlate with leptin and body mass index in Japanese adolescents
Platelet and white blood cell counts correlate with leptin and body mass index in Japanese adolescents Open
Obesity is associated with mild chronic inflammation, frequently observed along with increased platelet and white blood cell (WBC) levels in adults. We aimed to clarify the relationship between peripheral blood cell count, body mass index …
View article: Efficient protocol for the differentiation of kidney podocytes from induced pluripotent stem cells, involving the inhibition of mTOR
Efficient protocol for the differentiation of kidney podocytes from induced pluripotent stem cells, involving the inhibition of mTOR Open
The mechanistic/mammalian target of rapamycin (mTOR) is involved in a wide range of cellular processes. However, the role of mTOR in podocytes remains unclear. In this study, we aimed to clarify the role of mTOR in podocyte differentiation…
View article: Dysbiosis of the gut microbiota as a susceptibility factor for Kawasaki disease
Dysbiosis of the gut microbiota as a susceptibility factor for Kawasaki disease Open
Introduction Gut microbial imbalance (dysbiosis) has been reported in patients with acute Kawasaki disease (KD). However, no studies have analyzed the gut microbiota while focusing on susceptibility to KD. This study aimed to evaluate whet…
View article: Abnormal Development of Microbiota May Be a Risk Factor for Febrile Urinary Tract Infection in Infancy
Abnormal Development of Microbiota May Be a Risk Factor for Febrile Urinary Tract Infection in Infancy Open
Febrile urinary tract infection (fUTI) is common in infants, but specific risk factors for developing it remain unclear. As most fUTIs are caused by ascending infections of intestinal bacteria, dysbiosis—an imbalance in gut microbial commu…
View article: Diagnostic Significance of Absence of Post-Feeding Contraction of the Gallbladder in Biliary Atresia: Two Case Reports
Diagnostic Significance of Absence of Post-Feeding Contraction of the Gallbladder in Biliary Atresia: Two Case Reports Open
Ultrasonography is an essential part of the diagnostic process of biliary atresia (BA). The characteristic findings of BA include a hilar hyperechoic zone, the triangular cord sign (TCS), an absence of gallbladder contraction after feeding…
View article: Efficient protocol for the differentiation of kidney podocytes from induced pluripotent stem cells, involving the inhibition of mTOR
Efficient protocol for the differentiation of kidney podocytes from induced pluripotent stem cells, involving the inhibition of mTOR Open
The mechanistic/mammalian target of rapamycin (mTOR) is involved in a wide range of cellular processes. However, the role of mTOR in podocytes remains unclear. In this study, we aimed to clarify the role of mTOR in podocyte differentiation…
View article: Comparison of the characteristics and factors influencing hospital visits among children with nocturnal enuresis in Japan: The Hirakata–Urayasu population‐based cohort study
Comparison of the characteristics and factors influencing hospital visits among children with nocturnal enuresis in Japan: The Hirakata–Urayasu population‐based cohort study Open
Objectives The aim of this study was to compare the demographic characteristics of school‐aged children with nocturnal enuresis and factors influencing hospital visits between two regions in Japan. Methods A cross‐sectional survey was cond…
View article: Dysbiosis of gut microbiota in children with egg allergy
Dysbiosis of gut microbiota in children with egg allergy Open
腸内細菌叢はヒトの腸管内で一定のバランスを保ちながら共生する細菌集団であり，その代謝産物はヒトの健康に影響を与える．腸内細菌叢の乱れ（dysbiosis）は生涯においてさまざまな疾患の発症に関与している．アレルギー疾患患者の腸内細菌叢についてもdysbiosisを呈しているとする報告は多数あるが，その特徴やアレルギー疾患の発症機序に関してコンセンサスはない．
View article: Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes
Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes Open
Growth Hormone therapy has been shown to induce transient insulin resistance in children, and there is concern regarding the diabetogenic potential of GH therapy in children born small for gestational age (SGA). In this case, female patien…
View article: Evolution of collectivity in <sup>126,128</sup>Xe studied in Coulomb excitation measurements
Evolution of collectivity in <sup>126,128</sup>Xe studied in Coulomb excitation measurements Open
The characteristics of 126,128 Xe were investigated in Coulomb excitation measurements performed at the National Superconducting Cyclotron Laboratory (NSCL) Re-accelerator facility, ReA3, Michigan State University (MSU). The Xe nuclei were…
View article: Effect of a Bifidobacterium-Containing Acid-Resistant Microcapsule Formulation on Gut Microbiota: A Pilot Study
Effect of a Bifidobacterium-Containing Acid-Resistant Microcapsule Formulation on Gut Microbiota: A Pilot Study Open
Approximately 10 Bifidobacterium species are known to inhabit the human intestinal tract. Bifidobacteria have been reported to possess a variety of probiotic benefits. However, when bifidobacteria are consumed internally as probiotics, the…
View article: Transition from undergraduates to residents: A SWOT analysis of the expectations and concerns of Japanese medical graduates during the COVID-19 pandemic
Transition from undergraduates to residents: A SWOT analysis of the expectations and concerns of Japanese medical graduates during the COVID-19 pandemic Open
Introduction Interruptions in undergraduate clinical clerkship during the COVID-19 pandemic have reduced the confidence and preparedness of residents beginning their postgraduate training. We explore the thoughts of new residents about thi…