Kazunori Morohoshi
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View article: Engineered Human Dental Pulp Stem Cells with Promising Potential for Regenerative Medicine
Engineered Human Dental Pulp Stem Cells with Promising Potential for Regenerative Medicine Open
The fields of regenerative medicine and stem cell-based tissue engineering hold great potential for treating a wide range of tissue and organ defects. Stem cells are ideal candidates for regenerative medicine because they are undifferentia…
View article: A Simple and Safe Protocol for Intra-Testicular Gene Delivery in Neonatal Mice Using a Convenient Isoflurane-Based Anesthesia System
A Simple and Safe Protocol for Intra-Testicular Gene Delivery in Neonatal Mice Using a Convenient Isoflurane-Based Anesthesia System Open
Newborn mice (up to 6 d after birth) are suitable for genetic manipulations, such as facial vein-mediated injection, owing to their hairless and thin skin. Their small body volumes also facilitate the rapid dissemination of injected soluti…
View article: Complement Factor B Deficiency Is Dispensable for Female Fertility but Affects Microbiome Diversity and Complement Activity
Complement Factor B Deficiency Is Dispensable for Female Fertility but Affects Microbiome Diversity and Complement Activity Open
Complement factor B (CFB) is a crucial component for the activation of the alternative pathway due to the formation of the C3 convertase with C3b, which further produces C3b to enhance the overall complement activity. Although Cfb is expre…
View article: Possible Application of GONAD/<i>i</i>-GONAD, a Novel <i>In Vivo</i> Genome Editing Technology, to Generate Genome-edited Large Experimental Animals
Possible Application of GONAD/<i>i</i>-GONAD, a Novel <i>In Vivo</i> Genome Editing Technology, to Generate Genome-edited Large Experimental Animals Open
View article: Artificial Insemination as a Possible Convenient Tool to Acquire Genome-Edited Mice via In Vivo Fertilization with Engineered Sperm
Artificial Insemination as a Possible Convenient Tool to Acquire Genome-Edited Mice via In Vivo Fertilization with Engineered Sperm Open
Advances in genome editing technology have made it possible to create genome-edited (GE) animals, which are useful for identifying isolated genes and producing models of human diseases within a short period of time. The production of GE an…
View article: Recent Advances in the Production of Genome-Edited Animals Using <i>i</i>-GONAD, a Novel <i>in vivo</i> Genome Editing System, and Its Possible Use for the Study of Female Reproductive Systems
Recent Advances in the Production of Genome-Edited Animals Using <i>i</i>-GONAD, a Novel <i>in vivo</i> Genome Editing System, and Its Possible Use for the Study of Female Reproductive Systems Open
Gene-engineered animals created using gene-targeting technology have long been recognized as beneficial, valid, and valuable tools for exploring the function of a gene of interest, at least in early 2013. This approach, however, suffers fr…
View article: Recent Advances in In Vivo Somatic Cell Gene Modification in Newborn Pups
Recent Advances in In Vivo Somatic Cell Gene Modification in Newborn Pups Open
Germline manipulation at the zygote stage using the CRISPR/Cas9 system has been extensively employed for creating genetically modified animals and maintaining established lines. However, this approach requires a long and laborious task. Re…
View article: Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for Murine Spermatogenesis
Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for Murine Spermatogenesis Open
Proteasomes are highly sophisticated protease complexes that degrade non-lysosomal proteins, and their proper regulation ensures various biological functions such as spermatogenesis. The proteasome-associated proteins, PA200 and ECPAS, are…
View article: Suppressive Role of Lactoferrin in Overweight-Related Female Fertility Problems
Suppressive Role of Lactoferrin in Overweight-Related Female Fertility Problems Open
The secretory glycoprotein lactoferrin (LF) is suggested to ameliorate overweight regardless of non-genetic or genetic mechanisms. Although maternal overweight represents a key predictor of offspring growth, the efficacy of LF on fertility…
View article: Identification of an antibacterial polypeptide in mouse seminal vesicle secretions
Identification of an antibacterial polypeptide in mouse seminal vesicle secretions Open
In both men and women, pathogenic bacteria enter the reproductive tract and cause harmful symptoms. Intrauterine and oviductal inflammation after copulation may have severe effects, such as infertility, implantation failure, oviduct obstru…
View article: Estrogen induces phosphorylation of prolactin through p21-activated kinase 2 activation in the mouse pituitary gland
Estrogen induces phosphorylation of prolactin through p21-activated kinase 2 activation in the mouse pituitary gland Open
A phosphorylated prolactin is a kind of modified prolactin, which is produced through phosphorylation of native prolactin (PRL) by p21-activated kinase 2 (PAK2) in secretory granules in lactotrophs. Phosphorylated prolactin is involved in …
View article: 16 kDa vasoinhibin binds to integrin alpha5 beta1 on endothelial cells to induce apoptosis
16 kDa vasoinhibin binds to integrin alpha5 beta1 on endothelial cells to induce apoptosis Open
Many functions of vasoinhibins have been reported, but its receptor has not been clarified yet. Vasoinhibins, 11–18 kDa N-terminal fragments of prolactin, have anti-angiogenic activity and act on endothelial cells to induce apoptosis and t…