Kazunori Suzuki
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View article: Effects of ketamine pretreatment on tetrabenazine-induced motivational impairments in male rats performing an effort-based decision-making task
Effects of ketamine pretreatment on tetrabenazine-induced motivational impairments in male rats performing an effort-based decision-making task Open
Anhedonia, a core feature of major depressive disorder (MDD), consists of both consummatory and motivational elements; however, the exact behavioral and neurobiological mechanisms underlying anhedonia are not yet fully understood. Clinical…
View article: Boiling and Drying Accident of High-Level Liquid Waste in a Reprocessing Plant: Examination of the Time-Dependent Temperature Increase of the Waste and of the Generation Rates of the Individual Components Released into the Gas Phase
Boiling and Drying Accident of High-Level Liquid Waste in a Reprocessing Plant: Examination of the Time-Dependent Temperature Increase of the Waste and of the Generation Rates of the Individual Components Released into the Gas Phase Open
Using the amount, composition, and decay power density of high-level liquid waste in a storage tank, the temperature change of the waste up to 600°C and the corresponding vapor and gas release rates of H2O, HNO3, NO2, NO, and O2 as a funct…
View article: Effect of Ketamine Pretreatment on Tetrabenazine-Induced Motivational Impairments in Rats Performing an Effort-Based Decision-Making Task
Effect of Ketamine Pretreatment on Tetrabenazine-Induced Motivational Impairments in Rats Performing an Effort-Based Decision-Making Task Open
View article: Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice Open
Background The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation and degeneration. Therefore, the restoration of functional dystrophin levels is a fundamental approach fo…
View article: Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice Open
Background The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation and degeneration. Therefore, the restoration of functional dystrophin levels is a fundamental approach fo…
View article: PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke
PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke Open
Phosphodiesterase (PDE) inhibitors have been safely and effectively used in the clinic and increase the concentration of intracellular cyclic nucleotides (cAMP/cGMP). These molecules activate downstream mediators, including the cAMP respon…
View article: Practical Example of Cold Spraying
Practical Example of Cold Spraying Open
View article: Lamotrigine and retigabine increase motor threshold in transcranial magnetic stimulation at the dose required to produce an antiepileptic effect against maximal electroshock-induced seizure in rats
Lamotrigine and retigabine increase motor threshold in transcranial magnetic stimulation at the dose required to produce an antiepileptic effect against maximal electroshock-induced seizure in rats Open
Transcranial magnetic stimulation (TMS) is a neurophysiological technique that enables noninvasive evaluation of neuronal excitability in the brain. In the past, a large number of antiepileptic drugs were shown to increase the motor thresh…
View article: Correction to: Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type
Correction to: Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type Open
The original version of this article was revised due to retrospective Open Access.
View article: Translational Development Strategies for TAK-063, a Phosphodiesterase 10A Inhibitor
Translational Development Strategies for TAK-063, a Phosphodiesterase 10A Inhibitor Open
Background TAK-063 is an inhibitor of phosphodiesterase 10A (PDE10A), an enzyme highly expressed in medium spiny neurons of the striatum. PDE10A hydrolyzes both cyclic adenosine monophosphate and cyclic guanosine monophosphate and modulate…
View article: Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type
Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type Open
View article: Ⅰ Current Status and Issues of Plating Industry:
Ⅰ Current Status and Issues of Plating Industry: Open
スズキハイテック㈱) ，難波圭太郎氏 (オーエム産業㈱) 吉野 正洋氏 (吉野電化工業㈱)
View article: Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents
Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents Open
Background Faster off-rate competitive enzyme inhibitors are generally more sensitive than slower off-rate ones to binding inhibition by enzyme substrates. We previously reported that the cyclic adenosine monophosphate concentration in dop…
View article: Effect of Night-break-lighting at Different Times on Summer-to-autumn-flowering Small-flowered Spray-type Chrysanthemum
Effect of Night-break-lighting at Different Times on Summer-to-autumn-flowering Small-flowered Spray-type Chrysanthemum Open
The conventional timing of night-break-lighting to inhibit flower induction has been at midnight in Chrysanthemum morifolium. In this study, we investigated the light-sensitive time zone of summer-to-autumn-flowering small-flowered spray-t…
View article: S223. COMBINED TREATMENT WITH A SELECTIVE PDE10A INHIBITOR TAK-063 AND ANTIPSYCHOTICS AT SUBEFFECTIVE DOSES PRODUCES POTENT ANTIPSYCHOTIC-LIKE EFFECTS WITHOUT EXACERBATING SIDE EFFECTS PROFILE IN RODENTS
S223. COMBINED TREATMENT WITH A SELECTIVE PDE10A INHIBITOR TAK-063 AND ANTIPSYCHOTICS AT SUBEFFECTIVE DOSES PRODUCES POTENT ANTIPSYCHOTIC-LIKE EFFECTS WITHOUT EXACERBATING SIDE EFFECTS PROFILE IN RODENTS Open
Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action (MOA) of current antipsychotics with dopamine D2 receptor antagonism. Phosphodiesterase 10A (PDE10A) inhibitor…
View article: <scp>TAK</scp>‐063, a novel <scp>PDE</scp>10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia
<span>TAK</span>‐063, a novel <span>PDE</span>10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia Open
Summary The basal ganglia regulates motor, cognitive, and emotional behaviors. Dysfunction of dopamine system in this area is implicated in the pathophysiology of schizophrenia characterized by positive symptoms, negative symptoms, and cog…
View article: Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents
Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents Open
Activation of indirect pathway medium spiny neurons ( MSN s) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with dopamine D 2 receptor antagonism. TAK ‐063 [1‐[2‐fluoro‐4‐(1H‐pyrazol‐1‐yl)ph…
View article: De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions
De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions Open
View article: TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms
TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms Open
View article: Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor
Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor Open
Phosphodiesterase 10A (PDE10A) inhibition is a novel and promising approach for the treatment of central nervous system disorders such as schizophrenia and Huntington's disease. A novel PDE10A inhibitor, TAK-063 [1-[2-fluoro-4-(1H-pyrazol-…