Kazuya Ishida
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View article: Discovery of GS-7682, a Novel 4′-Cyano-Modified <i>C</i>-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Discovery of GS-7682, a Novel 4′-Cyano-Modified <i>C</i>-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys Open
Acute respiratory viral infections, such as pneumovirus and respiratory picornavirus infections, exacerbate disease in COPD and asthma patients. A research program targeting respiratory syncytial virus (RSV) led to the discovery of GS-7682…
View article: Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4′-CN-4-Aza-7,9-Dideazaadenosine<i>C</i>-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4′-CN-4-Aza-7,9-Dideazaadenosine<i>C</i>-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys Open
Acute respiratory viral infections (ARVI), such as pneumovirus and respiratory picornavirus infections, exacerbate disease in COPD and asthma patients. A research program targeting respiratory syncytial virus (RSV) led to the discovery of …
View article: Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach Open
View article: Transcriptomics-driven Evaluation on Liver Toxicity Using Adverse Outcome Pathways (AOP)
Transcriptomics-driven Evaluation on Liver Toxicity Using Adverse Outcome Pathways (AOP) Open
Because the liver is the primary target organ for chemicals and pharmaceuticals, evaluation of these substances' liver toxicity is of critical importance. New evaluation methods without animal testing (i.e., in vitro and/or in silico) are …
View article: Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides
Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides Open
View article: Successful Prediction of In Vivo Hepatobiliary Clearances and Hepatic Concentrations of Rosuvastatin Using Sandwich-Cultured Rat Hepatocytes, Transporter-Expressing Cell Lines, and Quantitative Proteomics
Successful Prediction of In Vivo Hepatobiliary Clearances and Hepatic Concentrations of Rosuvastatin Using Sandwich-Cultured Rat Hepatocytes, Transporter-Expressing Cell Lines, and Quantitative Proteomics Open
View article: The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse
The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse Open
Ribavirin is used for the treatment of hepatitis C virus (HCV) infection. The equilibrative nucleoside transporter 1 (ENT1) expressed in hepatocytes transports ribavirin into the liver, the site of efficacy of the drug. However, it is stil…
View article: Importance of Lipophilicity and Polar Surface Area of Compounds on the Transport Activity of Intestinal H<sup>+</sup>/tertiary Amine Antiporter
Importance of Lipophilicity and Polar Surface Area of Compounds on the Transport Activity of Intestinal H<sup>+</sup>/tertiary Amine Antiporter Open
The aims of the present study were to evaluate whether the postulated H+/tertiary amine antiporter is expressed in human intestinal HT-29 cells as well as other cell lines, Caco-2 and LS180, and to identify the factor(s) of the uptake acti…