Kazuya Tsubouchi
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View article: Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis
Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis Open
There are no established biomarkers for acute exacerbations in idiopathic pulmonary fibrosis (AE-IPF). The bronchoalveolar lavage fluid of patients with IPF notably has elevations in high-mobility group box 1 protein (HMGB1), a nuclear non…
View article: Prognostic impact of muscle mass in idiopathic interstitial pneumonia: analysis of idiopathic pulmonary fibrosis and other idiopathic interstitial pneumonias
Prognostic impact of muscle mass in idiopathic interstitial pneumonia: analysis of idiopathic pulmonary fibrosis and other idiopathic interstitial pneumonias Open
Background Low skeletal muscle mass has been reported to associated with poor prognosis in patients with idiopathic pulmonary fibrosis (IPF). However, such associations have scarcely reported in idiopathic interstitial pneumonias (IIPs) ot…
View article: Upfront combination therapy with nintedanib and anti-inflammatory agents for progressive pulmonary fibrosis: a multicenter, single-arm phase 2 study (TOP-ILD)
Upfront combination therapy with nintedanib and anti-inflammatory agents for progressive pulmonary fibrosis: a multicenter, single-arm phase 2 study (TOP-ILD) Open
Objective Progressive pulmonary fibrosis (PPF) is a chronic interstitial lung disease (ILD) characterized by fibrotic progression and poor prognosis, with effective treatment strategies for previously untreated patients remaining unclear. …
View article: Association Between Single Nucleotide Polymorphisms and Disease Susceptibility, Survival, and Acute Exacerbation in Idiopathic Pulmonary Fibrosis
Association Between Single Nucleotide Polymorphisms and Disease Susceptibility, Survival, and Acute Exacerbation in Idiopathic Pulmonary Fibrosis Open
Background and Objective Genetic polymorphisms have been associated with susceptibility to interstitial lung diseases including idiopathic pulmonary fibrosis (IPF). We have now examined the relation between single nucleotide polymorphisms …
View article: Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis
Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis Open
There are no established biomarkers for acute exacerbations in idiopathic pulmonary fibrosis (AE-IPF). The bronchoalveolar lavage fluid of patients with IPF notably has elevations in high-mobility group box 1 protein (HMGB1), a nuclear non…
View article: Prognostic Impact of Muscle Mass in Idiopathic Interstitial Pneumonia: Analysis of Idiopathic Pulmonary Fibrosis and Other Idiopathic Interstitial Pneumonias
Prognostic Impact of Muscle Mass in Idiopathic Interstitial Pneumonia: Analysis of Idiopathic Pulmonary Fibrosis and Other Idiopathic Interstitial Pneumonias Open
Background Low skeletal muscle mass has been reported to associated with poor prognosis in patients with idiopathic pulmonary fibrosis (IPF). However, such associations have scarcely reported in idiopathic interstitial pneumonias (IIPs) ot…
View article: Diagnostic yield and safety of transbronchial lung cryobiopsy using 1.7-mm probes in interstitial lung disease
Diagnostic yield and safety of transbronchial lung cryobiopsy using 1.7-mm probes in interstitial lung disease Open
The incorporation of TBLC pathological findings in the MDD improved diagnostic certainty and facilitated decisions regarding treatment strategies. TBLC using a 1.7-mm single-use probe with a freezing duration of 5 s can safely obtain suffi…
View article: Mortality and exacerbation risk according to GOLD and STAR severity stages of COPD: a 5-year multicenter prospective cohort study
Mortality and exacerbation risk according to GOLD and STAR severity stages of COPD: a 5-year multicenter prospective cohort study Open
View article: Involvement of naïve T cells in the pathogenesis of osimertinib-induced pneumonitis
Involvement of naïve T cells in the pathogenesis of osimertinib-induced pneumonitis Open
Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effectively treats EGFR-mutated non-small cell lung cancer. Drug-induced interstitial lung disease, a potentially fatal complication of osim…
View article: Immunophenotyping of T Cells in Lung Malignancies and Cryptogenic Organizing Pneumonia
Immunophenotyping of T Cells in Lung Malignancies and Cryptogenic Organizing Pneumonia Open
Background: Lung malignancies, including cancerous lymphangitis and lymphomas, can mimic interstitial lung diseases like cryptogenic organizing pneumonia (COP) on imaging, leading to diagnostic delays. We aimed to identify potential biomar…
View article: The Evaluation of the Diagnostic Yield and Complications Associated with Bronchoscopy via Endobronchial Ultrasound with a Guide Sheath
The Evaluation of the Diagnostic Yield and Complications Associated with Bronchoscopy via Endobronchial Ultrasound with a Guide Sheath Open
Background and objective Endobronchial ultrasound with a guide sheath (EBUS-GS) is used to accurately position a bronchoscope in lung lesions using a guide sheath. Previous studies have focused on diagnostic success as the endpoint. The ac…
View article: Krebs von den Lungen-6 surveillance in immune checkpoint inhibitor-induced pneumonitis
Krebs von den Lungen-6 surveillance in immune checkpoint inhibitor-induced pneumonitis Open
Background The immune-related adverse event (irAE), pneumonitis, is a potentially fatal complication of immune checkpoint inhibitors (ICIs). Preventing its progression is crucial, emphasizing the need for effective screening tests. We eval…
View article: Update of prognosis and characteristics of chronic obstructive pulmonary disease in a real-world setting: a 5-year follow-up analysis of a multi-institutional registry
Update of prognosis and characteristics of chronic obstructive pulmonary disease in a real-world setting: a 5-year follow-up analysis of a multi-institutional registry Open
Our study presents the 5-year survival and real-world clinical practice scenario of a prospective cohort of patients clinically diagnosed with COPD in Japan in the mid-2010s. The survival rates of our cohort were numerically better than th…
View article: The Utility and Limitations of Universal Polymerase Chain Reaction Screening for SARS-CoV-2 During Hospital Admission
The Utility and Limitations of Universal Polymerase Chain Reaction Screening for SARS-CoV-2 During Hospital Admission Open
Hospital admission based on the results of PCR screening for SARS-CoV-2 should take into account not only PCR positivity but also the Ct value and recent COVID-19 history.
View article: Lemborexant‐induced interstitial lung disease: A case report
Lemborexant‐induced interstitial lung disease: A case report Open
We report the first case of drug‐induced interstitial lung disease attributed to lemborexant. A 66‐year‐old man reported to our hospital with the acute onset of cough and breathlessness with ground‐glass opacity on radiological examination…
View article: Author response: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Author response: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis Open
View article: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis Open
Anticancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia …
View article: Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma
Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma Open
Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, t…
View article: Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases
Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases Open
This study aimed to analyse whether initiating nintedanib treatment at a reduced dose could improve the treatment continuation rate while maintaining efficacy in patients with connective tissue disease (CTD)-associated interstitial lung di…
View article: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis Open
Anti-cancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia…
View article: Author Response: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Author Response: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis Open
Anti-cancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia…
View article: Reviewer #2 (Public Review): Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Reviewer #2 (Public Review): Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis Open
Anti-cancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia…
View article: Prognosis and management of chronic obstructive pulmonary disease in a real-world setting: A 5-year follow-up analysis of a multi-institutional registry
Prognosis and management of chronic obstructive pulmonary disease in a real-world setting: A 5-year follow-up analysis of a multi-institutional registry Open
Background We conducted a prospective observational study to elucidate the long-term prognosis and management of chronic obstructive pulmonary disease (COPD) in Japan in the mid-2010s in clinical practice. Methods This prospective cohort s…
View article: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis Open
Anti-cancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia…
View article: Author Response: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Author Response: Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis Open
Anti-cancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia…
View article: Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα
Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα Open
Mucin overproduction is a common feature of chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), and exacerbates their underlying respiratory condition. Surfactant protein D (SP-D) protects against airwa…
View article: Survival and acute exacerbation for patients with idiopathic pulmonary fibrosis (IPF) or non-IPF idiopathic interstitial pneumonias: 5-year follow-up analysis of a prospective multi-institutional patient registry
Survival and acute exacerbation for patients with idiopathic pulmonary fibrosis (IPF) or non-IPF idiopathic interstitial pneumonias: 5-year follow-up analysis of a prospective multi-institutional patient registry Open
Objective Few prospective cohort studies with relatively large numbers of patients with non-idiopathic pulmonary fibrosis (non-IPF) of idiopathic interstitial pneumonia (IIP) have been described. We aimed to assess disease progression and …
View article: Reply to: Huang <i>et al.</i>
Reply to: Huang <i>et al.</i> Open
"Reply to: Tacrolimus and the Treatment of Pulmonary Fibrosis." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Altered macrophage phenotypes in a case of autoimmune pulmonary alveolar proteinosis
Altered macrophage phenotypes in a case of autoimmune pulmonary alveolar proteinosis Open
Mass cytometry of BALF cells from a pulmonary alveolar proteinosis patient, positive for anti-GM-CSF antibodies, suggests potential impairment in human alveolar macrophage differentiation https://bit.ly/45JHUrz.
View article: Acute myeloid leukemia and myelodysplastic syndrome associated with a combination of immune checkpoint inhibitor and platinum‐based chemotherapy
Acute myeloid leukemia and myelodysplastic syndrome associated with a combination of immune checkpoint inhibitor and platinum‐based chemotherapy Open
Therapy related‐acute myeloid leukemia (t‐AML) and myelodysplastic syndrome (t‐MDS) are complications of chemotherapy and/or radiation therapy for malignant diseases. In this report, we describe a patient with advanced lung adenocarcinoma …