Kazuyuki Kasahara
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View article: Bacteroides- and Prevotella-enriched gut microbial clusters associate with metabolic risks
Bacteroides- and Prevotella-enriched gut microbial clusters associate with metabolic risks Open
The gut microbiome plays a critical role in human health through its influence on numerous physiological functions such as metabolism and immunity, with disruptions in microbial communities increasingly linked to metabolic disorders. In a …
View article: Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis
Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis Open
Gut bacterial metabolism of dietary flavonoids results in the production of a variety of phenolic acids, whose contributions to health remain poorly understood. Here, we show that supplementation with the commonly consumed flavonoid querce…
View article: Current frailty knowledge, awareness, and practices among physicians following the 2022 European consensus document on Frailty in Cardiology
Current frailty knowledge, awareness, and practices among physicians following the 2022 European consensus document on Frailty in Cardiology Open
Aims Aging-related cardiovascular disease and frailty burdens are anticipated to rise with global aging. In response to directions from major cardiovascular societies, we investigated frailty knowledge, awareness, and practices among cardi…
View article: Dissecting the impact of dietary fiber type on atherosclerosis in mice colonized with different gut microbial communities
Dissecting the impact of dietary fiber type on atherosclerosis in mice colonized with different gut microbial communities Open
View article: Gut bacterial metabolism contributes to host global purine homeostasis
Gut bacterial metabolism contributes to host global purine homeostasis Open
The microbes and microbial pathways that influence host inflammatory disease progression remain largely undefined. Here, we show that variation in atherosclerosis burden is partially driven by gut microbiota and is associated with circulat…
View article: Author Correction: Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut
Author Correction: Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut Open
View article: Gut microbiota and diet matrix modulate the effects of the flavonoid quercetin on atherosclerosis
Gut microbiota and diet matrix modulate the effects of the flavonoid quercetin on atherosclerosis Open
View article: Dissecting the impact of dietary fiber type on atherosclerosis in mice colonized with different gut microbial communities
Dissecting the impact of dietary fiber type on atherosclerosis in mice colonized with different gut microbial communities Open
Dietary fiber consumption has been linked with improved cardiometabolic health, however human studies have reported large interindividual variations in the observed benefits. We tested whether the effects of dietary fiber on atherosclerosi…
View article: Gut bacteria impact host uric acid burden and its association with atherosclerosis
Gut bacteria impact host uric acid burden and its association with atherosclerosis Open
Humans with metabolic and inflammatory diseases, including atherosclerosis harbor dysbiotic gut communities. However, the microbes and microbial pathways that influence disease progression remain largely undefined. Here, we show that varia…
View article: Depletion of Foxp3+ regulatory T cells augments CD4+ T cell immune responses in atherosclerosis-prone hypercholesterolemic mice
Depletion of Foxp3+ regulatory T cells augments CD4+ T cell immune responses in atherosclerosis-prone hypercholesterolemic mice Open
View article: The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass
The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass Open
Roux-en-Y gastric bypass (RYGB) is efficient at inducing drastic albeit variable weight loss and type-2 diabetes (T2D) improvements in patients with severe obesity and T2D. We hypothesized a causal implication of the gut microbiota (GM) in…
View article: Gut Bacteria Impact Host Uric Acid Burden and Its Association With Atherosclerosis
Gut Bacteria Impact Host Uric Acid Burden and Its Association With Atherosclerosis Open
View article: Systems genetics uncovers microbe-lipid-host connections in the murine gut
Systems genetics uncovers microbe-lipid-host connections in the murine gut Open
The molecular bases of how host genetic variation impact gut microbiome remain largely unknown. Here, we used a genetically diverse mouse population and systems genetics strategies to identify interactions between molecular phenotypes, inc…
View article: Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model
Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model Open
View article: Sexual dimorphism of cardiometabolic dysfunction: Gut microbiome in the play?
Sexual dimorphism of cardiometabolic dysfunction: Gut microbiome in the play? Open
Emerging evidence suggests the role of gut microbiome as a modifier of disease susceptibility due to sex; however, the impact on cardiometabolic disease in this complex interplay is lacking. Elucidating the role of gut microbiome on sex-bi…
View article: Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation
Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation Open
View article: Additional file 2: of Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation
Additional file 2: of Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation Open
Table S2. OTU Table. (XLSX 1328Â kb)
View article: Additional file 1: of Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation
Additional file 1: of Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation Open
Table S1. Sample sequence parameters. (XLSX 14Â kb)
View article: Ultraviolet B Exposure Inhibits Angiotensin II–Induced Abdominal Aortic Aneurysm Formation in Mice by Expanding CD4 <sup>+</sup> Foxp3 <sup>+</sup> Regulatory T Cells
Ultraviolet B Exposure Inhibits Angiotensin II–Induced Abdominal Aortic Aneurysm Formation in Mice by Expanding CD4 <sup>+</sup> Foxp3 <sup>+</sup> Regulatory T Cells Open
Background Pathogenic immune responses are known to play an important role in abdominal aortic aneurysm ( AAA ) development. Ultraviolet B ( UVB ) irradiation has been demonstrated to have therapeutic potential not only for cutaneous disea…
View article: Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis
Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis Open
The gut microbiota were shown to play critical roles in the development of atherosclerosis, but the detailed mechanism is limited. The purpose of this study is to clarify the influence of gut microbiota on atherogenesis via lipid metabolis…
View article: UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses
UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses Open
Objective— UVB irradiation is an established treatment for immunoinflammatory cutaneous disorders and has been shown to suppress cutaneous and systemic inflammatory diseases through modulation of the adaptive immune response. However, it r…
View article: Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice
Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice Open
Objective— Although T-cell–mediated chronic inflammation contributes to atherosclerosis development, the role of a negative regulatory molecule cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) in atherosclerosis is poorly understood. W…
View article: Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease
Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease Open
Although this study had some limitations, we demonstrated that the incidence of CAD was linked with an alteration of gut microbiota. A prospective study is desired to clarify a causal relationship between CAD and gut microbiota.
View article: Anti-inflammatory and immune-modulatory therapies for preventing atherosclerotic cardiovascular disease
Anti-inflammatory and immune-modulatory therapies for preventing atherosclerotic cardiovascular disease Open
View article: Intestinal Immunity and Gut Microbiota as Therapeutic Targets for Preventing Atherosclerotic Cardiovascular Diseases
Intestinal Immunity and Gut Microbiota as Therapeutic Targets for Preventing Atherosclerotic Cardiovascular Diseases Open
Atherosclerosis is considered a chronic inflammatory disease and an intervention targeting the inflammatory process could be a new therapeutic strategy for preventing atherosclerotic cardiovascular diseases (CVD). We hypothesized that the …
View article: CONTENTS OF VOLUME 79, 2015
CONTENTS OF VOLUME 79, 2015 Open