Kejun Liu
YOU?
Author Swipe
View article: Comparing the effect of traditional and novel tyrosine kinase inhibitors for epidermal growth factor receptor exon 20 insertions by molecular dynamics simulation
Comparing the effect of traditional and novel tyrosine kinase inhibitors for epidermal growth factor receptor exon 20 insertions by molecular dynamics simulation Open
Background Exon 20 insertions of epidermal growth factor receptor (EGFR) exhibit varying sensitivity to traditional and novel tyrosine kinase inhibitors for non-small cell lung cancer. Methods Molecular dynamics simulations were used to in…
View article: Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer
Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer Open
Primary liver cancer (PLC) and metformin are not well understood to be associated. We conducted a Mendelian randomization (MR) analysis using genetic data from IEU OpenGWAS and FinnGen R10, with metformin as the exposure and PLC as the out…
View article: Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis Open
Mastitis, driven by oxidative-inflammatory responses to S. aureus, lacks efficient therapies. Recently, protein-anthocyanin encapsulation has shown significant advances in biomedicine, but it faces structural stability/suboptimal ef…
View article: Single-cell RNA profiling reveals an immunosuppressive microenvironment in EGFR double-mutant non-small cell lung cancer
Single-cell RNA profiling reveals an immunosuppressive microenvironment in EGFR double-mutant non-small cell lung cancer Open
scFocuSCOPE precisely delineated tumor heterogeneity and immune suppression in EGFR-DM NSCLC. The complex immune landscape of EGFR-DM tumors offers valuable insights for future mechanistic studies and personalized therapies.
View article: The combination of immune checkpoint inhibitor and chemotherapy may be efficacious for advanced non-small cell lung cancer with near-loop insertions of <i>EGFR</i> exon 20: A retrospective analysis
The combination of immune checkpoint inhibitor and chemotherapy may be efficacious for advanced non-small cell lung cancer with near-loop insertions of <i>EGFR</i> exon 20: A retrospective analysis Open
Objective The sensitivity of immune checkpoint inhibitors (ICIs) as monotherapy is low in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor ( EGFR ) exon 20 insertion mutations (ex20ins). This study aims at …
View article: Diagnostic value of multi-tumor-associated autoantibody expression in esophageal squamous cell carcinoma and correlation of clinical features
Diagnostic value of multi-tumor-associated autoantibody expression in esophageal squamous cell carcinoma and correlation of clinical features Open
Objective This study aimed to investigate the diagnostic value of 7-tumor associated autoantibodies (7-TAAB) and to evaluate the relationship between 7-TAAB and clinical features in esophageal squamous cell carcinoma (ESCC), which can be u…
View article: Smile upon the Face but Sadness in the Eyes: Emotion Recognition based on Facial Expressions and Eye Behaviors
Smile upon the Face but Sadness in the Eyes: Emotion Recognition based on Facial Expressions and Eye Behaviors Open
Emotion Recognition (ER) is the process of identifying human emotions from given data. Currently, the field heavily relies on facial expression recognition (FER) because facial expressions contain rich emotional cues. However, it is import…
View article: Treatment of late left bronchopleural fistula after left pneumonectomy through right thoracic approach assisted by extracorporeal membrane oxygenation
Treatment of late left bronchopleural fistula after left pneumonectomy through right thoracic approach assisted by extracorporeal membrane oxygenation Open
View article: Treatment of late left bronchopleural fistula after left pneumonectomy through right thoracic approach assisted by extracorporeal membrane oxygenation
Treatment of late left bronchopleural fistula after left pneumonectomy through right thoracic approach assisted by extracorporeal membrane oxygenation Open
Background Bronchopleural fistula (BPF) is a rare but fatal complication after pneumonectomy. When a BPF occurs late (weeks to years postoperatively), direct resealing of the bronchial stump through the primary thoracic approach is challen…
View article: Comparison of neoadjuvant chemoimmunotherapy and chemotherapy alone for resectable stage III non-small cell lung cancer: a real-world cohort study
Comparison of neoadjuvant chemoimmunotherapy and chemotherapy alone for resectable stage III non-small cell lung cancer: a real-world cohort study Open
Background We compared the real-world efficacy and safety of neoadjuvant chemoimmunotherapy to chemotherapy alone in patients with stage III non-small-cell lung cancer (NSCLC). Participants and methods A total of 59 consecutive patients we…
View article: Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway
Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway Open
View article: Identification of a Novel CD8+ T cell exhaustion-related gene signature for predicting survival in hepatocellular carcinoma
Identification of a Novel CD8+ T cell exhaustion-related gene signature for predicting survival in hepatocellular carcinoma Open
View article: Effects of dietary sodium butyrate on growth performance, immune function, and intestinal microflora of Chinese soft-shelled turtle (Pelodiscus sinensis)
Effects of dietary sodium butyrate on growth performance, immune function, and intestinal microflora of Chinese soft-shelled turtle (Pelodiscus sinensis) Open
The Chinese soft-shelled turtle ( Pelodiscus sinensis ) has become increasingly susceptible to frequent diseases with the intensification of farming, which severely impacts the development of the aquaculture industry. Sodium butyrate (SB) …
View article: Learning Language-guided Adaptive Hyper-modality Representation for Multimodal Sentiment Analysis
Learning Language-guided Adaptive Hyper-modality Representation for Multimodal Sentiment Analysis Open
Though Multimodal Sentiment Analysis (MSA) proves effective by utilizing rich information from multiple sources (e.g., language, video, and audio), the potential sentiment-irrelevant and conflicting information across modalities may hinder…
View article: Systemic lupus erythematosus promotes HCC by promoting cell cycle C2/M transition
Systemic lupus erythematosus promotes HCC by promoting cell cycle C2/M transition Open
Objective To investigate whether there is an association between immune abnormalities and hepatocellular carcinogenesis in patients with the autoimmune disease systemic lupus erythematosus (SLE), and to explore the possible mechanisms of t…
View article: Risk prediction for dermatomyositis-associated hepatocellular carcinoma
Risk prediction for dermatomyositis-associated hepatocellular carcinoma Open
Objective To explore dermatomyositis signature genes as potential biomarkers of hepatocellular carcinoma and their associated molecular regulatory mechanisms. Methods Based on the mRNA-Seq data of dermatomyositis and hepatocellular carcino…
View article: Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway
Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway Open
Objective To investigate the effect of COVID-19 infection on pancreatic cancer . Methods Based on the mRNA-Seq data of COVID-19 patients and pancreatic cancer (PC) patients in the GEO database, we used support vector machine (SVM), LASSO-C…
View article: Identification of ferroptosis signature genes in hepatocellular carcinoma and renal clear cell carcinoma
Identification of ferroptosis signature genes in hepatocellular carcinoma and renal clear cell carcinoma Open
Objective To investigate the common ferroptosis signature genes in two cancers based on the disease commonality between hepatocellular carcinoma and renal clear cell carcinoma. Methods Based on the mRNA-seq data and matched clinical data o…
View article: Risk prediction for Dermatomyositis-associated hepatocellular carcinoma
Risk prediction for Dermatomyositis-associated hepatocellular carcinoma Open
Objective To explore dermatomyositis signature genes as potential biomarkers of hepatocellular carcinoma and their associated molecular regulatory mechanisms. Methods Based on the mRNA-Seq data of dermatomyositis and hepatocellular carcino…
View article: Learning Language-guided Adaptive Hyper-modality Representation for Multimodal Sentiment Analysis
Learning Language-guided Adaptive Hyper-modality Representation for Multimodal Sentiment Analysis Open
Though Multimodal Sentiment Analysis (MSA) proves effective by utilizing rich information from multiple sources (*e.g.,* language, video, and audio), the potential sentiment-irrelevant and conflicting information across modalities may hind…
View article: Prognostic signature of transmembrane protein family gene for Hepatocellular carcinoma patients based on transcriptomics
Prognostic signature of transmembrane protein family gene for Hepatocellular carcinoma patients based on transcriptomics Open
Transmembrane protein (TMEM) genes family are presented in the biological membrane. The TMEM gene family is involved in the proliferation, invasion, and migration of carcinogenesis in digestive system cancers. We therefore probe extremely …
View article: Pose-disentangled Contrastive Learning for Self-supervised Facial Representation
Pose-disentangled Contrastive Learning for Self-supervised Facial Representation Open
Self-supervised facial representation has recently attracted increasing attention due to its ability to perform face understanding without relying on large-scale annotated datasets heavily. However, analytically, current contrastive-based …
View article: Relationship between Prognosis with Dynamic Changes of Thyroid Hormone and Cortisol Hormone in Patients with Severe Craniocerebral Injury
Relationship between Prognosis with Dynamic Changes of Thyroid Hormone and Cortisol Hormone in Patients with Severe Craniocerebral Injury Open
Objective. To analyze the dynamic changes of thyroid hormone and cortisol hormone (COR) and their relationship with prognosis in patients with severe craniocerebral injury. Methods. A retrospective analysis of 48 patients with severe crani…
View article: Pan-cancer analysis of the prognostic and immunological role of ANLN: An onco-immunological biomarker
Pan-cancer analysis of the prognostic and immunological role of ANLN: An onco-immunological biomarker Open
Anillin actin-binding protein (ANLN) is crucially involved in cell proliferation and migration. Moreover, ANLN is significantly in tumor progression in several types of human malignant tumors; however, it remains unclear whether ANLN acts …
View article: Clinical characteristics and antibodies against Echinococcus granulosus recombinant antigen P29 in patients with cystic echinococcosis in China
Clinical characteristics and antibodies against Echinococcus granulosus recombinant antigen P29 in patients with cystic echinococcosis in China Open
View article: A Cost-Effectiveness Analysis of Screening Strategies Involving Non-Invasive Prenatal Testing for Trisomy 21
A Cost-Effectiveness Analysis of Screening Strategies Involving Non-Invasive Prenatal Testing for Trisomy 21 Open
Introduction In accordance with social development, the proportion of advanced maternal age (AMA) increased and the cost of non-invasive prenatal testing (NIPT) decreased. Objective We aimed to investigate the benefits and cost-effectivene…
View article: Glucose-6-Phosphate Dehydrogenase is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma
Glucose-6-Phosphate Dehydrogenase is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma Open
Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in the metabolic and immunological aspects of tumors. In hepatocellular carcinoma (HCC), the alteration of tumor microenvironment influences recurrence and metastasis. We ext…
View article: ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial–mesenchymal transition
ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial–mesenchymal transition Open
View article: Overexpression of ID1 mediates resistance to osimertinib in T790M positive non-small cell lung cancer through epithelial-mesenchymal transition
Overexpression of ID1 mediates resistance to osimertinib in T790M positive non-small cell lung cancer through epithelial-mesenchymal transition Open
Objective To analyzed the effect of ID1 overexpression on osimertinib resistance to T790M positive non-small cell lung cancer (NSCLC). Methods We established drug resistant cell line H1975/OR from osimertinib sensitive cell line H1975. Pro…
View article: Platelet/lymphocyte ratio is a significant prognostic factor for targeted therapy in patients with EGFR-mutated non-small-cell lung cancer
Platelet/lymphocyte ratio is a significant prognostic factor for targeted therapy in patients with EGFR-mutated non-small-cell lung cancer Open
Objective To analyze the prognostic significance of the pretreatment platelet/lymphocyte ratio (PLR) for targeted therapy in patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). Methods We condu…