Xin Wang
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View article: APOBEC3B-driven mutations negatively regulated by P53 promote tumor progression and immunosuppressive microenvironment in prostate cancer
APOBEC3B-driven mutations negatively regulated by P53 promote tumor progression and immunosuppressive microenvironment in prostate cancer Open
APOBEC3B (A3B), a key cytosine deaminase, plays a multifaceted role in the malignant progression of various cancers. However, the precise role of A3B in prostate cancer (PCa) remains largely elusive. This study aimed to investigate the fun…
View article: Clinicopathological characteristics, genetic aberrations, and optimized treatment strategies in double-hit and triple-hit lymphoma: a multi-center cohort study
Clinicopathological characteristics, genetic aberrations, and optimized treatment strategies in double-hit and triple-hit lymphoma: a multi-center cohort study Open
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements constitutes a distinct clinicopathological entity characterized by aggressive behavior, inherent resistance to conventional immunochemotherapy, and suboptimal clinical…
View article: Clinical effectiveness of scleral taping combined with perfluoropropane for complex retinal detachment
Clinical effectiveness of scleral taping combined with perfluoropropane for complex retinal detachment Open
Purpose This study evaluated the effectiveness of scleral taping combined with C3F8 gas filling for the management of complex retinal detachment (CRD) and to objectively assessed its clinical value. Methods Forty consecutive patients (40 e…
View article: [Retracted] Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway
[Retracted] Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Open
[This retracts the article DOI: 10.3892/etm.2018.6021.].
View article: Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling
Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling Open
Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse mo…
View article: Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease
Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease Open
Previous research has highlighted lysosomal ion channel-related genes (LICRGs) as promising therapeutic targets for neurodegenerative diseases. This study aimed to identify and analyze LICRG-associated biomarkers for Alzheimer’s disease (A…
View article: Nanoscopy Reveals Heparan Sulfate Clusters as Docking Sites for SARS-CoV-2 Attachment and Entry
Nanoscopy Reveals Heparan Sulfate Clusters as Docking Sites for SARS-CoV-2 Attachment and Entry Open
Virus entry is thought to involve binding a unique receptor for cell attachment and cytosolic entry. For SARS-CoV-2 underlying the COVID-19 pandemic, angiotensin- converting enzyme 2 (ACE2) is widely assumed as the receptor. Using advanced…
View article: Targeting <scp>ARPC1B</scp> <sup>+</sup> Cancer Stem Cells to Sensitise Pancreatic Cancer to Gemcitabine Treatment
Targeting <span>ARPC1B</span> <sup>+</sup> Cancer Stem Cells to Sensitise Pancreatic Cancer to Gemcitabine Treatment Open
ARPC1B+ cancer stem cells (CSCs) in pancreatic cancer are identified as a subpopulation resistant to gemcitabine. In our study, drug repositioning, molecular docking, and surface plasmon resonance (SPR) technique jointly revealed that CK-6…
View article: The m6A Modification in T Helper Cells Regulates the Pathogenesis of Autoimmune Diseases
The m6A Modification in T Helper Cells Regulates the Pathogenesis of Autoimmune Diseases Open
The pathogenesis of autoimmune diseases remains unclear, which is associated with T helper (Th) cell subsets such as Th1, Th2, Treg and Tfh cells. Recent studies have indicated the involvement of N6-methyladenosine (m6A) modification in th…
View article: Peripheral T‐cell lymphoma with central nervous system involvement and elevated interleukin‐10 levels in the cerebrospinal fluid: A case report
Peripheral T‐cell lymphoma with central nervous system involvement and elevated interleukin‐10 levels in the cerebrospinal fluid: A case report Open
Central nervous system (CNS) involvement in peripheral T‐cell lymphoma (PTCL) is rare and is associated with poor prognosis. This report presents two pathologically confirmed PTCL cases. Although cerebrospinal fluid (CSF) flow cytometry di…
View article: Case report: A case of intravascular large B-cell lymphoma and related literature review
Case report: A case of intravascular large B-cell lymphoma and related literature review Open
Intravascular large B-cell lymphoma (IVLBCL) presents with a wide range of clinical symptoms, making clinical diagnosis challenging. It is often misdiagnosed or overlooked, leading to delays in treatment for affected patients. We present a…
View article: Targeted drug delivery systems in Lymphoma treatment: Advances and clinical perspectives
Targeted drug delivery systems in Lymphoma treatment: Advances and clinical perspectives Open
Lymphomas are a heterogeneous group of hematologic tumors that pose a significant challenge in precise treatment. With the development of novel intervention strategies in lymphoma, such as targeted drugs and cell therapy, the prognosis and…
View article: New insights into microRNA in dermatological diseases
New insights into microRNA in dermatological diseases Open
MicroRNAs (miRs) are a class of non-coding RNA molecules that regulate gene expression post-transcriptionally. MiRs, as translational repression and/or degradation of target messenger RNAs, are critical regulators of various physiological …
View article: Engineered exosomes: a promising design platform for overcoming cancer therapy resistance
Engineered exosomes: a promising design platform for overcoming cancer therapy resistance Open
Therapeutic resistance is a formidable barrier in cancer treatment, necessitating innovative solutions to enhance drug efficacy. Exosomes, with their unparalleled biocompatibility, low immunogenicity, and robust cargo protection, have emer…
View article: Effects of Different Doses of Esketamine on Postoperative Analgesia and Recovery Quality in Lumbar Decompression Surgery: A Randomized Controlled Trial Focusing on the Advantages of Sub-Anesthetic Doses
Effects of Different Doses of Esketamine on Postoperative Analgesia and Recovery Quality in Lumbar Decompression Surgery: A Randomized Controlled Trial Focusing on the Advantages of Sub-Anesthetic Doses Open
Background : The optimal esketamine dose for opioid-sparing analgesia in lumbar decompression surgery remains controversial, particularly regarding its dose-dependent effects on recovery quality and safety. Methods : In this single-center,…
View article: Insights Into the Association Between Stroke and Sarcopenia Risk in Adults Aged ≥ 50 Years: Cross‐Sectional Evidence From Two Large Population Longitudinal Cohorts
Insights Into the Association Between Stroke and Sarcopenia Risk in Adults Aged ≥ 50 Years: Cross‐Sectional Evidence From Two Large Population Longitudinal Cohorts Open
Background and aim Evidence has already shown that sarcopenia is linked to an elevated risk of cardiovascular disease (CVD). However, the association between stroke and sarcopenia risk remains underexplored in stroke and non‐stroke populat…
View article: Tislelizumab plus nab-paclitaxel and cisplatin as induction immunochemotherapy for organ preservation of locally advanced hypopharyngeal squamous cell carcinoma: a single-arm phase II trial
Tislelizumab plus nab-paclitaxel and cisplatin as induction immunochemotherapy for organ preservation of locally advanced hypopharyngeal squamous cell carcinoma: a single-arm phase II trial Open
Tislelizumab plus nab-paclitaxel and cisplatin appears to be a promising induction immunochemotherapy regimen for organ preservation, showing encouraging efficacy and a favorable safety profile in untreated locally advanced HPSCC, warranti…
View article: Response gene to complement 32 promotes tumorigenesis by mediating DNA damage repair and inhibits CD8+ T cells infiltration in diffuse large B-cell lymphoma
Response gene to complement 32 promotes tumorigenesis by mediating DNA damage repair and inhibits CD8+ T cells infiltration in diffuse large B-cell lymphoma Open
Background Response gene to complement 32 (RGC32), a complement activation-inducible factor broadly expressed in normal human tissues, has been implicated in tumorigenesis through its dysregulated expression in various malignancies and its…
View article: The Population Ecological Characteristics of Gongshan Muntjac (<i>Muntiacus gongshanensis</i>) in Southeastern Tibet Based on Camera‐Trap Technology
The Population Ecological Characteristics of Gongshan Muntjac (<i>Muntiacus gongshanensis</i>) in Southeastern Tibet Based on Camera‐Trap Technology Open
The Gongshan muntjac ( Muntiacus gongshanensis ) is one of the least understood ungulate species and is classified as Critically Endangered (CR) on China's Vertebrates Red List and assessed as Data Deficient (DD) by the IUCN. Its elusive b…
View article: [Retracted] MEG‑3‑mediated Wnt/β‑catenin signaling pathway controls the inhibition of tunicamycin‑mediated viability in glioblastoma
[Retracted] MEG‑3‑mediated Wnt/β‑catenin signaling pathway controls the inhibition of tunicamycin‑mediated viability in glioblastoma Open
[This retracts the article DOI: 10.3892/ol.2018.9048.].
View article: Association of neutrophil-to-lymphocyte ratio with all-cause and cardiovascular mortality among cardiovascular-kidney-metabolic syndrome: a national cross-sectional study
Association of neutrophil-to-lymphocyte ratio with all-cause and cardiovascular mortality among cardiovascular-kidney-metabolic syndrome: a national cross-sectional study Open
The neutrophil-to-lymphocyte ratio (NLR) as inflammatory biomarker across cardiovascular outcomes. However, its relationship with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic (CKM) syndrome remains poorly chara…
View article: Screening and validation of 3’-Methoxydaidzein as a therapeutic agent in ulcerative colitis based on disulfidptosis-associated molecular clusters
Screening and validation of 3’-Methoxydaidzein as a therapeutic agent in ulcerative colitis based on disulfidptosis-associated molecular clusters Open
Background Ulcerative colitis (UC) is a recurrent inflammatory condition of the bowel with a multifaceted pathogenesis, including programmed cell death, oxidative stress, and immune-mediated inflammation. As a recently identified type of c…