Ke Yang
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View article: Metal‐Free and Selective Synthesis of Benzo[ <i>d</i> ]Isothiazol‐3(2 <i>H</i> )‐Ones and Corresponding 1‐Oxides
Metal‐Free and Selective Synthesis of Benzo[ <i>d</i> ]Isothiazol‐3(2 <i>H</i> )‐Ones and Corresponding 1‐Oxides Open
Metal‐free and selective synthesis of benzo[ d ]isothiazol‐3(2 H )‐ones and corresponding 1‐oxides has been developed. The use of NCS enables the formation of a diverse range of benzo[ d ]isothiazol‐3(2 H )‐ones from 2‐mercaptobenzamides i…
View article: Recent Advances in the Synthesis of 4H-Benzo[d][1,3]oxathiin-4-ones and 4H-Benzo[d][1,3]dioxin-4-ones
Recent Advances in the Synthesis of 4H-Benzo[d][1,3]oxathiin-4-ones and 4H-Benzo[d][1,3]dioxin-4-ones Open
4H-Benzo[d][1,3]oxathiin-4-ones and 4H-benzo[d][1,3]dioxin-4-ones, as important classes of sulfur- or oxygen-containing heterocyclic compounds, possess significant application potential in the fields of pharmaceutical chemistry, agricultur…
View article: Proteomic and histopathologic profiling reveal molecular features and clinical biomarkers of coronary atherosclerosis
Proteomic and histopathologic profiling reveal molecular features and clinical biomarkers of coronary atherosclerosis Open
View article: Multi-omics investigation of Bisphenol A in gastrointestinal carcinogenesis: a network toxicology and molecular docking approach
Multi-omics investigation of Bisphenol A in gastrointestinal carcinogenesis: a network toxicology and molecular docking approach Open
Our study aims to systematically investigate the potential carcinogenic mechanisms of bisphenol A (BPA) in three gastrointestinal tumors: intrahepatic cholangiocarcinoma (ICC), colorectal cancer (CRC), and esophageal cancer. By systematica…
View article: Single cell RNA sequencing reveals the reshaping effect of perfluorooctanoic acid on the intestinal microenvironment of mice
Single cell RNA sequencing reveals the reshaping effect of perfluorooctanoic acid on the intestinal microenvironment of mice Open
View article: Metal-Free C(sp3)–S Bond Cleavage of Thioethers to Selectively Access Aryl Aldehydes and Dithioacetals
Metal-Free C(sp3)–S Bond Cleavage of Thioethers to Selectively Access Aryl Aldehydes and Dithioacetals Open
Metal-free C(sp3)–S bond cleavage of thioethers was achieved using NCS as a critical additive. A wide range of arylmethyl thioethers were successfully transformed into aryl aldehydes with satisfactory yields in chloroform. Meanwhile, emplo…
View article: Recent Advances in the Synthesis of Benzo[d]isothiazol-3(2H)-One and Benzo[e][1,3]Thiazin-4-One Derivatives
Recent Advances in the Synthesis of Benzo[d]isothiazol-3(2H)-One and Benzo[e][1,3]Thiazin-4-One Derivatives Open
Benzo[d]isothiazol-3(2H)-one and benzo[e][1,3]thiazin-4-one derivatives, as significant sulfur- and nitrogen-containing heterocyclic compounds, are prevalent in natural products, pharmaceuticals, and food items. In recent years, a variety …
View article: Palladium-Catalyzed Cascade Reactions for Synthesis of Heterocycles Initiated by C(sp3)–H Functionalization
Palladium-Catalyzed Cascade Reactions for Synthesis of Heterocycles Initiated by C(sp3)–H Functionalization Open
Heterocycles are widely present in natural products, pharmaceuticals, and organic functional materials. In heterocycle synthesis, Pd-catalyzed cascade C–H functionalization has been regarded as one of the most powerful approaches due to it…
View article: Selective Oxidation of Benzo[d]isothiazol-3(2H)-Ones Enabled by Selectfluor
Selective Oxidation of Benzo[d]isothiazol-3(2H)-Ones Enabled by Selectfluor Open
A metal-free and Selectfluor-mediated selective oxidation reaction of benzo[d]isothiazol-3(2H)-ones in aqueous media is presented. This novel strategy provides a facile, green, and efficient approach to access important benzo[d]isothiazol-…
View article: Promotion and mechanism of defective hematite on the power generation and phenanthrene degradation of soil microbial fuel cells
Promotion and mechanism of defective hematite on the power generation and phenanthrene degradation of soil microbial fuel cells Open
Iron minerals can significantly impact the performance of soil microbial fuel cells (Soil-MFCs) through extracellular electron transfer (EET). Introducing defects into iron minerals has been shown to reinforce the microbial dissolution pro…
View article: Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands
Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands Open
2-Pyridone ligand-facilitated palladium-catalyzed direct C–H bond functionalization via the transient directing group strategy has become an attractive topic. Here, we report a Pd-catalyzed direct β-C(sp3)–H arylation reaction of tertiary …
View article: Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands
Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands Open
2-Pyridone ligand-facilitated palladium-catalyzed direct C–H bond functionalization via the transient directing group strategy has become an attractive topic. Here we report a Pd-catalyzed direct β-C(sp3) –H arylation reaction of tertiary …
View article: The Influence of a Key Indicator kv on the Diffusion Range of Underwater Oil Spill
The Influence of a Key Indicator kv on the Diffusion Range of Underwater Oil Spill Open
As oil spills cause harm to the survival and environment of the ocean, the objective of the present paper is to study the oil migration range using the key indicator kv, which is defined as the ratio of oil spill speed to ocean current spe…
View article: Multi-Factor Coupling Analysis of Porous Leakage in Underwater Gas Pipelines
Multi-Factor Coupling Analysis of Porous Leakage in Underwater Gas Pipelines Open
Natural gas pipeline leaks under the sea will have a significant negative effect on the marine ecosystem, result in significant financial losses, and possibly even harm marine floating objects. The VOF (Volume of Fluid) multi-phase flow mo…
View article: Pulmonary arterial hypertension associated with congenital heart disease: An omics study
Pulmonary arterial hypertension associated with congenital heart disease: An omics study Open
Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is a severely progressive condition with uncertain physiological course. Hence, it has become increasingly relevant to clarify the specific mechanisms of mo…
View article: Ruthenium-Catalyzed Β-Alkylation of Secondary Alcohols with Primary Alcohols: Protic N-Heterocyclic Carbene's Promotional Influence
Ruthenium-Catalyzed Β-Alkylation of Secondary Alcohols with Primary Alcohols: Protic N-Heterocyclic Carbene's Promotional Influence Open
View article: Recent Strategies in Nickel-Catalyzed C–H Bond Functionalization for Nitrogen-Containing Heterocycles
Recent Strategies in Nickel-Catalyzed C–H Bond Functionalization for Nitrogen-Containing Heterocycles Open
N-heterocycles are ubiquitous in natural products, pharmaceuticals, organic materials, and numerous functional molecules. Among the current synthetic approaches, transition metal-catalyzed C–H functionalization has gained considerable atte…
View article: Distribution characteristics and ecological risk assessment of heavy metals in sediments of Shahe reservoir
Distribution characteristics and ecological risk assessment of heavy metals in sediments of Shahe reservoir Open
Shahe Reservoir of Northern Canal Basin was selected as the study area. Nineteen surface (0~20 cm) sediment samples and three sediment core samples were collected to analyze the spatial distribution characteristics of As, Cd, Cu, Mn, Pb an…
View article: Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications Open
The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received special attention because of its function in the development and progression of cardiovascular disease. Numerous investigations have been performed over …
View article: Ecological Risk Assessment and Influencing Factors of Heavy-Metal Leaching From Coal-Based Solid Waste Fly Ash
Ecological Risk Assessment and Influencing Factors of Heavy-Metal Leaching From Coal-Based Solid Waste Fly Ash Open
In order to promote and broaden the utilization of fly ash as a resource, the fly ash from a 2,660-MW coal-fired power plant in Huainan (China) was investigated. The physical and chemical properties of fly ash were characterized by scannin…
View article: Recent advances in direct α-C(sp3)-H bond functionalization of thioethers
Recent advances in direct α-C(sp3)-H bond functionalization of thioethers Open
Thioether skeletons are widely present in drugs, natural products, functional materials, and life science. In the past decade, the selective C–H functionalization of thioethers has been extensively studied to construct novel thioether deri…
View article: Transition-metal-catalyzed remote C–H functionalization of thioethers
Transition-metal-catalyzed remote C–H functionalization of thioethers Open
This minireview systematically introduces the major advances and their mechanisms in the field of transition-metal-catalyzed remote C–H functionalization of thioethers.
View article: Ligand-promoted palladium-catalyzed β-methylene C–H arylation of primary aldehydes
Ligand-promoted palladium-catalyzed β-methylene C–H arylation of primary aldehydes Open
Aliphatic aldehydes are among the most common structural units in organic and medicinal chemistry research. Direct C–H functionalization has enabled efficient and site-selective derivatization of aliphatic aldehydes.
View article: Identification of Key CircRNAs Related to Pulmonary Tuberculosis Based on Bioinformatics Analysis
Identification of Key CircRNAs Related to Pulmonary Tuberculosis Based on Bioinformatics Analysis Open
Pulmonary tuberculosis (TB) is a chronic infectious disease that is caused by respiratory infections, principally Mycobacterium tuberculosis . Increasingly, studies have shown that circular (circ)RNAs play regulatory roles in different dis…
View article: Updates on Evaporation and Condensation Methods for the Performance Improvement of Solar Stills
Updates on Evaporation and Condensation Methods for the Performance Improvement of Solar Stills Open
Solar still, a small equipment using evaporation and condensation processes to get clean water, is expected to be widely used for sea/brackish water desalination, water purification, and wastewater treatment because of its convenient carry…
View article: Physical model experiment on the influence of water depth on the underwater pipeline surface impacted by landslide surge
Physical model experiment on the influence of water depth on the underwater pipeline surface impacted by landslide surge Open
View article: Calixarene Promoted Transition-Metal-Catalyzed Reactions
Calixarene Promoted Transition-Metal-Catalyzed Reactions Open
In recent years, transition metal catalyzed reactions have become one of the most effective methods to construct carbon-carbon bonds and carbon-heteroatom bonds in organic chemistry, and have attracted great research interest among chemist…
View article: The Influence of Oil leaking rate and Ocean Current Velocity on the Migration and Diffusion of Underwater Oil Spill
The Influence of Oil leaking rate and Ocean Current Velocity on the Migration and Diffusion of Underwater Oil Spill Open
View article: Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy
Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy Open
This minireview introduces Pd-catalyzed direct asymmetric C–H functionalization reactions using a directing group strategy.
View article: Silver-Promoted Site-Selective Intramolecular Cyclization of 2-Methylthiobenzamide Through α-C(sp<sup>3</sup>)–H Functionalization
Silver-Promoted Site-Selective Intramolecular Cyclization of 2-Methylthiobenzamide Through α-C(sp<sup>3</sup>)–H Functionalization Open
Silver-mediated intramolecular α-C(sp3)-H bond functionalization of the methylthio group has been established in the presence of Selectfluor as an additive. This novel strategy provides efficient access to various diverse sulfur…