Keara Monaghan
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View article: Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis
Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis Open
Metastatic outgrowth requires that cancer cells delaminate from the primary tumor, intravasate, survive in circulation, extravasate, migrate to, and proliferate at a distal site. Recurrent genetic drivers of metastasis remain elusive, sugg…
View article: Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis
Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis Open
Summary Cancer is the second leading cause of death globally, due primarily to metastatic dissemination and colonization of distal sites. Recurrent genetic drivers of metastasis are elusive, suggesting that, unlike the stereotyped mutation…
View article: Limitations to Understanding Intestinal Stem Cell Activity via Cre-Lox–Based Lineage Tracing
Limitations to Understanding Intestinal Stem Cell Activity via Cre-Lox–Based Lineage Tracing Open
The intestinal epithelium is a highly proliferative tissue with robust regenerative potential, governed by the intestinal stem cell (ISC) compartment. Our understanding of the cellular hierarchy within this compartment is drawn from Cre-lo…