Kaiqi Long
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View article: Intravitreal injection of cell membrane-coated nanoparticles for retinoblastoma treatment
Intravitreal injection of cell membrane-coated nanoparticles for retinoblastoma treatment Open
Chemotherapy is a widely adopted treatment for malignant intraocular tumors such as retinoblastoma. However, achieving high delivery efficiency remains challenging due to rapid clearance and lack of targeting specificity. Cancer cell membr…
View article: Opto-Epigenetic Regulation of Histone Arginine Asymmetric Dimethylation via Type I Protein Arginine Methyltransferase Inhibition
Opto-Epigenetic Regulation of Histone Arginine Asymmetric Dimethylation via Type I Protein Arginine Methyltransferase Inhibition Open
Histone arginine asymmetric dimethylation, which is mainly catalyzed by type I protein arginine methyltransferases (PRMTs), is involved in broad biological and pathological processes. Recently, several type I PRMT inhibitors, such as MS023…
View article: Correction to “Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy”
Correction to “Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy” Open
[This corrects the article DOI: 10.1021/acsptsci.1c00230.].
View article: Prediction of Ecological and Economic Impact of a Fuel-to-Electric Bus Engine Transition– With a Case Study of Shanghai
Prediction of Ecological and Economic Impact of a Fuel-to-Electric Bus Engine Transition– With a Case Study of Shanghai Open
Replacing fuel buses with electric buses is a key step for sustainable development. From the perspectives of both firms and the government, the process requires quantitative analysis to understand its ecological and economic impacts. Howev…
View article: Light‐Activated Anti‐Vascular Combination Therapy against Choroidal Neovascularization
Light‐Activated Anti‐Vascular Combination Therapy against Choroidal Neovascularization Open
Choroidal neovascularization (CNV) underlies the crux of many angiogenic eye disorders. Although medications that target vascular endothelial growth factor (VEGF) are approved for treating CNV, their effectiveness in destroying new blood v…
View article: 730 nm Light‐Induced Cleavage of BODIPY Photocages via Entropy‐Driven Triplet Sensitization
730 nm Light‐Induced Cleavage of BODIPY Photocages via Entropy‐Driven Triplet Sensitization Open
Light‐activated drug delivery systems allow precise spatiotemporal control of a drug release process. However, safe and efficient drug release activation needs a low‐power nonpulsed red/near‐infrared light with high tissue penetration dept…
View article: Photoresponsive Drug Delivery Systems: Challenges and Progress
Photoresponsive Drug Delivery Systems: Challenges and Progress Open
Photoresponsive drug delivery systems (PDDSs) have emerged as a promising toolbox for drug delivery, offering precise control over the site, duration, and dosage of light‐triggered medication. It allows controlled drug release, photo‐trigg…
View article: Near-infrared light-triggered prodrug photolysis by one-step energy transfer
Near-infrared light-triggered prodrug photolysis by one-step energy transfer Open
Prodrug photolysis enables spatiotemporal control of drug release at the desired lesions. For photoactivated therapy, near-infrared (NIR) light is preferable due to its deep tissue penetration and low phototoxicity. However, most of the ph…
View article: Red Light‐Triggered Anti‐Angiogenic and Photodynamic Combination Therapy of Age‐Related Macular Degeneration (Adv. Sci. 31/2023)
Red Light‐Triggered Anti‐Angiogenic and Photodynamic Combination Therapy of Age‐Related Macular Degeneration (Adv. Sci. 31/2023) Open
Red Light‐Activated Combination Therapy of Eye Diseases In article number 2301985, Xiaoling Liang, Weiping Wang, and co‐workers report a red‐light‐triggered intraocular drug release strategy to achieve combination treatment of wet age‐rela…
View article: Red Light‐Triggered Anti‐Angiogenic and Photodynamic Combination Therapy of Age‐Related Macular Degeneration
Red Light‐Triggered Anti‐Angiogenic and Photodynamic Combination Therapy of Age‐Related Macular Degeneration Open
Choroidal neovascularization (CNV) is the key pathological event of wet age‐related macular degeneration (wAMD) leading to irreversible vision loss. Currently, anti‐angiogenic therapy with anti‐vascular endothelial growth factor (VEGF) age…
View article: Near-infrared Light-Triggered Prodrug Photolysis by One-step Energy Transfer
Near-infrared Light-Triggered Prodrug Photolysis by One-step Energy Transfer Open
The following files are available in this Supplementary Information file. Materials and methods; Figure S1 to S45, Table S1 to S6 of the manuscript entitled "Near-infrared Light-Triggered Prodrug Photolysis by One-step Energy Transfer"
View article: Carrier‐free nanodrugs for stemness inhibition‐enhanced photodynamic therapy
Carrier‐free nanodrugs for stemness inhibition‐enhanced photodynamic therapy Open
Cancer stem cell (CSC) has been considered a key driver of tumor growth, recurrence, and metastasis due to its self‐renewal and tumor initiation capacities called stemness. Stemness is also responsible for the high resistance of CSC to cur…
View article: H<sub>2</sub>S‐Responsive Small‐Molecule Nanocarriers for Drug Delivery to Colorectal Tumors (Adv. Therap. 9/2022)
H<sub>2</sub>S‐Responsive Small‐Molecule Nanocarriers for Drug Delivery to Colorectal Tumors (Adv. Therap. 9/2022) Open
In article number 2200044, Weiping Wang and co-workers developed a H2S-responsive nanocarrier based on the self-assembly of trigonal small molecules. Hydrophobic drugs, such as doxorubicin, can be encapsulated and precisely released in the…
View article: Optochemical Control of Immune Checkpoint Blockade via Light‐Triggered PD‐L1 Dimerization
Optochemical Control of Immune Checkpoint Blockade via Light‐Triggered PD‐L1 Dimerization Open
ImmunotherapyIn article number 2200017, Weiping Wang and co-workers report a photoactivatable and biocompatible prodrug. The prodrug is not able to block PD-1 (expressed on T cells (yellow)) and PD-L1 (expressed on cancer cells (blue)) int…
View article: Optochemical Control of Immune Checkpoint Blockade via Light‐Triggered PD‐L1 Dimerization
Optochemical Control of Immune Checkpoint Blockade via Light‐Triggered PD‐L1 Dimerization Open
The blockade of PD‐1/PD‐L1, which serves to “release the brake” of tumor immunity, represents a promising approach for treating various malignancies. However, the systemic immune‐related side effects significantly undermine its therapeutic…
View article: Photoresponsive prodrug‐dye nanoassembly for in‐situ monitorable cancer therapy
Photoresponsive prodrug‐dye nanoassembly for in‐situ monitorable cancer therapy Open
Photocleavable prodrugs enable controllable drug delivery to target sites modulated by light irradiation. However, the in vivo utility is usually hindered by their insolubility and inefficient delivery. In this study, we report a simple st…
View article: Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy
Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy Open
As an important regulator of cell metabolism, proliferation, and survival, mTOR (mammalian target of rapamycin) signaling provides both a potential target for cancer treatment and a research tool for investigation of cell metabolism. One i…
View article: One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery Open
Background Photoresponsive drug delivery can achieve spatiotemporal control of drug accumulation at desired sites. Long-wavelength light is preferable owing to its deep tissue penetration and low toxicity. One-photon upconversion-like phot…
View article: Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma (Adv. Sci. 20/2021)
Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma (Adv. Sci. 20/2021) Open
Light‐Triggered Drug Release In article number 2101754, Changyou Zhan, Weiping Wang, and co‐workers develop an “intravenous injection plus light‐triggered intraocular drug release” strategy to achieve drug accumulation in retinoblastoma. T…
View article: Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma
Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma Open
Retinoblastoma is one of the most severe ocular diseases, of which current chemotherapy is limited to the repetitive intravitreal injections of chemotherapeutics. Systemic drug administration is a less invasive route; however, it is also l…