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View article: Biomphalaria snails release immune proteins in aquaculture water that influence egg production and development
Biomphalaria snails release immune proteins in aquaculture water that influence egg production and development Open
View article: Advances and prospects of respiratory mucosal vaccines: mechanisms, technologies, and clinical applications
Advances and prospects of respiratory mucosal vaccines: mechanisms, technologies, and clinical applications Open
Respiratory mucosal immunity constitutes a critical barrier against pathogen invasion and has emerged as a promising target for vaccine development. This review outlines current understanding of its mechanisms, recent technological advance…
View article: Clinical challenges and technological breakthroughs in helminthic therapy for diabetes
Clinical challenges and technological breakthroughs in helminthic therapy for diabetes Open
Helminthic therapy, as an emerging strategy for Diabetes Mellitus (DM), demonstrates significant clinical benefits by modulating host immune and metabolic systems. Studies have shown that this approach effectively enhances insulin sensitiv…
View article: Comparative immunological roles of TEP1 in Anopheles gambiae and Biomphalaria glabrata: implications for malaria and schistosomiasis control
Comparative immunological roles of TEP1 in Anopheles gambiae and Biomphalaria glabrata: implications for malaria and schistosomiasis control Open
Malaria and schistosomiasis represent two of the most significant global parasitic diseases in terms of public health burden. These diseases are transmitted through Anopheles mosquitoes and freshwater snails, respectively. Although their t…
View article: Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context
Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context Open
Introduction Toll-like receptors (TLRs) are transmembrane proteins essential for innate immunity. While vertebrate TLRs have been well studied, knowledge of their distribution, structure, and function in mollusks remains limited, despite t…
View article: Drug Repurposing: In Vitro Evaluation of Simeprevir as a Novel Antiviral Drug Against Severe Fever With Thrombocytopenia Syndrome Virus
Drug Repurposing: In Vitro Evaluation of Simeprevir as a Novel Antiviral Drug Against Severe Fever With Thrombocytopenia Syndrome Virus Open
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick‐borne virus with high mortality, currently lacks approved antiviral therapies. In this study, we evaluated the in vitro activity of 19 FDA‐approved drugs against a clinical …
View article: Toxicity of dimethylformamide at different developmental stages of Biomphalaria glabrata: Lethal concentration determination and longitudinal assessment of physiological changes
Toxicity of dimethylformamide at different developmental stages of Biomphalaria glabrata: Lethal concentration determination and longitudinal assessment of physiological changes Open
Dimethylformamide (DMF) is a widely used polar organic solvent with potential hepatotoxicity and environmental release risks. DMF, as an important industrial solvent, poses a high risk of environmental leakage, particularly in aquatic envi…
View article: Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment
Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment Open
Vaccines are a fundamental tool in the prevention and control of infectious diseases; however, significant individual variability in immunogenicity exists. This variability is not solely attributable to vaccine characteristics but is also …
View article: A comparative analysis of immune memory in bivalve and gastropod Mollusks: From mechanistic insights to practical applications
A comparative analysis of immune memory in bivalve and gastropod Mollusks: From mechanistic insights to practical applications Open
View article: The potential and challenges of circular RNA in the development of vaccines and drugs for emerging infectious diseases
The potential and challenges of circular RNA in the development of vaccines and drugs for emerging infectious diseases Open
Circular RNAs (circRNAs) are a class of RNA molecules with a covalent closed-loop structure that play important roles in the regulation of biological processes and disease genesis. In recent years, circRNAs have become a research hotspot d…
View article: Harnessing cellular immunity for next-generation vaccines against respiratory viruses: mechanisms, platforms, and optimization strategies
Harnessing cellular immunity for next-generation vaccines against respiratory viruses: mechanisms, platforms, and optimization strategies Open
Respiratory tract infections, such as influenza, respiratory syncytial virus (RSV) infection, and COVID-19, remain a persistent threat to global public health due to their high transmissibility and disease burden. Vaccination, as a key pre…
View article: Latest advances and prospects in the pathogenesis, animal models, and vaccine research of severe fever with thrombocytopenia syndrome virus
Latest advances and prospects in the pathogenesis, animal models, and vaccine research of severe fever with thrombocytopenia syndrome virus Open
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick-borne phlebovirus first identified in China, causes severe illness characterized by high fever, thrombocytopenia, leukopenia, and, in some cases, multi-organ failure and dea…
View article: AI-based large-scale screening of gastric cancer from noncontrast CT imaging
AI-based large-scale screening of gastric cancer from noncontrast CT imaging Open
View article: Toxicological Effects of Glufosinate-Ammonium-Containing Commercial Formulations on Biomphalaria glabrata in Aquatic Environments: A Multidimensional Study from Embryotoxicity to Histopathology
Toxicological Effects of Glufosinate-Ammonium-Containing Commercial Formulations on Biomphalaria glabrata in Aquatic Environments: A Multidimensional Study from Embryotoxicity to Histopathology Open
Glufosinate-ammonium (GLA) is a broad-spectrum herbicide widely used for weed control. However, its potential toxic effects on non-target aquatic organisms, especially in freshwater ecosystems, are of growing concern. This study investigat…
View article: Modelling of flaky particle motion under typical vibration excitation for gas insulated switchgear live operation
Modelling of flaky particle motion under typical vibration excitation for gas insulated switchgear live operation Open
Within 30 min after live operation of gas‐insulated switchgear (GIS), more than 60% of discharge failures are caused by metallic particles. To address this issue, this study explored the vibration propagation mechanisms in GIS cavities and…
View article: From Biomphalaria glabrata to Drosophila melanogaster and Anopheles gambiae: the diversity and role of FREPs and Dscams in immune response
From Biomphalaria glabrata to Drosophila melanogaster and Anopheles gambiae: the diversity and role of FREPs and Dscams in immune response Open
Fibrinogen-related proteins (FREPs) and Down syndrome cell adhesion molecules (Dscams) are important immune-related molecules in invertebrates. Although they are found in different taxonomic groups and possess unique functions, both exhibi…
View article: Helminth-induced immune modulation in colorectal cancer: exploring therapeutic applications
Helminth-induced immune modulation in colorectal cancer: exploring therapeutic applications Open
Colorectal cancer is one of the most lethal tumors, posing a financial and healthcare burden. This study investigates how helminths and pre-existing diseases such as colitis, obesity, diabetes, and gut microbiota issues influence colon can…
View article: Prevention and control of schistosomiasis in the Philippines from a health education perspective
Prevention and control of schistosomiasis in the Philippines from a health education perspective Open
Schistosomiasis, second only to malaria, poses a significant threat to many regions worldwide, particularly tropical and subtropical areas. The Philippines, located in a tropical region, has long suffered from the serious public health haz…
View article: Functional insights into immunoglobulin superfamily proteins in invertebrate neurobiology and immunity
Functional insights into immunoglobulin superfamily proteins in invertebrate neurobiology and immunity Open
The Immunoglobulin Superfamily (IgSF) represents a vital protein family widely distributed in animal genomes, encompassing multifunctional proteins with immunoglobulin-like domains, including immunoglobulins. These proteins play pivotal ro…
View article: Advancements in the application and research of baculovirus vector vaccines for respiratory diseases in human
Advancements in the application and research of baculovirus vector vaccines for respiratory diseases in human Open
The rapid spread of respiratory diseases, such as influenza, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Respiratory Syncytial Virus (RSV), poses significant ch…
View article: Low Neutralization of SARS‐CoV‐2 Omicron BA5248, XBB15 and JN1 by Homologous Booster and Breakthrough Infection
Low Neutralization of SARS‐CoV‐2 Omicron BA5248, XBB15 and JN1 by Homologous Booster and Breakthrough Infection Open
Immunity against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) can be induced through either infection with the virus or vaccination, providing protection against reinfection or reducing the risk of severe clinical outcomes.…
View article: Developmental Toxicity and Environmental Risk Assessment of Chlorothalonil: A Comprehensive Study Using Biomphalaria as a Model Gastropod
Developmental Toxicity and Environmental Risk Assessment of Chlorothalonil: A Comprehensive Study Using Biomphalaria as a Model Gastropod Open
View article: Dual threat: Susceptibility mechanisms and treatment strategies for COVID-19 and bacterial co-infections
Dual threat: Susceptibility mechanisms and treatment strategies for COVID-19 and bacterial co-infections Open
COVID-19 has rapidly spread worldwide, posing significant challenges to public health systems. This review offers an in-depth examination of the mechanisms underlying susceptibility and associated clinical features, and treatment strategie…
View article: Geographical Distribution and Ecological Niche Changes of Four Evergreen Broad-Leaved Quercus Species in China Under Climate Change
Geographical Distribution and Ecological Niche Changes of Four Evergreen Broad-Leaved Quercus Species in China Under Climate Change Open
View article: Advances in the structure-based design of protein vaccines for respiratory infectious diseases
Advances in the structure-based design of protein vaccines for respiratory infectious diseases Open
View article: Anti-Inflammatory Effects of Helminth-Derived Products: Potential Applications and Challenges in Diabetes Mellitus Management
Anti-Inflammatory Effects of Helminth-Derived Products: Potential Applications and Challenges in Diabetes Mellitus Management Open
The global rise in diabetes mellitus (DM), particularly type 2 diabetes (T2D), has become a major public health challenge. According to the "hygiene hypothesis", helminth infections may offer therapeutic benefits for DM. These infections a…
View article: Artificial intelligence for disease X: Progress and challenges
Artificial intelligence for disease X: Progress and challenges Open
View article: Research progress on environmental stability of SARS-CoV-2 and influenza viruses
Research progress on environmental stability of SARS-CoV-2 and influenza viruses Open
We reviewed research on SARS-CoV-2 and influenza virus detection on surfaces, their persistence under various conditions, and response to disinfectants. Viral contamination in community and healthcare settings was analyzed, emphasizing sur…
View article: The impact of antibiotic induction on virulence and antibiotic resistance in Klebsiella pneumoniae: a comparative study of CSKP and CRKP strains
The impact of antibiotic induction on virulence and antibiotic resistance in Klebsiella pneumoniae: a comparative study of CSKP and CRKP strains Open
Background Klebsiella pneumoniae is an opportunistic pathogen causing nosocomial infections, classified into carbapenem-sensitive and carbapenem-resistant strains. Understanding the virulence factors and antibiotic resistance of these stra…
View article: Ultra-rapid detection of nuclear protein of severe fever with thrombocytopenia syndrome virus by colloidal gold immunochromatography assay
Ultra-rapid detection of nuclear protein of severe fever with thrombocytopenia syndrome virus by colloidal gold immunochromatography assay Open
In 2009, severe fever with thrombocytopenia syndrome virus (SFTSV), also known as the Dabie bandavirus (DBV), was first discovered in Henan, China. It is a tick-borne zoonotic virus with a fatality rate ranging from 6% to 30%. Currently, w…