Keely Dulmage
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View article: Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea
Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea Open
Archaeal molecular biology has been a topic of intense research in recent decades as their role in global ecosystems, nutrient cycles, and eukaryotic evolution comes to light. The hypersaline-adapted archaeal species Halobacterium salinaru…
View article: Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea
Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea Open
Because archaea are the evolutionary ancestors of eukaryotes, archaeal molecular biology has been a topic of intense recent research. The hypersaline adapted archaeal species Halobacterium salinarum and Haloferax volcanii serve as importan…
View article: Data and scripts from: Copy number variation is associated with gene expression change in archaea
Data and scripts from: Copy number variation is associated with gene expression change in archaea Open
Genomic instability, although frequently deleterious, is also an important mechanism for microbial adaptation to environmental change. Although widely studied in bacteria, in archaea the effect of genomic instability on organism phenotypes…
View article: Transcriptional profiling of single tumour cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra‐cellular matrix marker expression
Transcriptional profiling of single tumour cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra‐cellular matrix marker expression Open
Dear Editor, Malignant pleural effusions (MPE) in advanced non-small-cell lung cancer (NSCLC) offer a rich source of tumour-derived material for liquid biopsy.1 However, molecular monitoring of NSCLC is largely dependent on tumour biopsies…
View article: An integrated enrichment system to facilitate isolation and molecular characterization of single cancer cells from whole blood
An integrated enrichment system to facilitate isolation and molecular characterization of single cancer cells from whole blood Open
Circulating tumor cells (CTCs) carry valuable biological information. While enumeration of CTCs in peripheral blood is an FDA‐approved prognostic indicator of survival in metastatic prostate and other cancers, analysis of CTC phenotypic an…
View article: Copy number variation is associated with gene expression change in archaea
Copy number variation is associated with gene expression change in archaea Open
Genomic instability, although frequently deleterious, is also an important mechanism for microbial adaptation to environmental change. Although widely studied in bacteria, in archaea the effect of genomic instability on organism phenotypes…
View article: An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters
An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters Open
Comprehensive molecular analysis of rare circulating tumor cells (CTCs) and cell clusters is often hampered by low throughput and purity, as well as cell loss. To address this, we developed a fully integrated platform for flow cytometry-ba…