Keerthihan Thiyagarajah
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View article: Higher prevalence of Cytomegalovirus and Epstein–Barr virus in acute-on-chronic liver failure
Higher prevalence of Cytomegalovirus and Epstein–Barr virus in acute-on-chronic liver failure Open
View article: Generation and Characterization of HDV-Specific Antisera with Respect to Their Application as Specific and Sensitive Research and Diagnostic Tools
Generation and Characterization of HDV-Specific Antisera with Respect to Their Application as Specific and Sensitive Research and Diagnostic Tools Open
The hepatitis D virus (HDV) is a small, defective RNA virus that induces the most severe form of viral hepatitis. Despite its severity, HDV infections are under-diagnosed due to non-standardized and costly diagnostic screening methods. How…
View article: Differential impact of hepatitis delta virus replication and expression of viral antigens on the cellular kinome profile
Differential impact of hepatitis delta virus replication and expression of viral antigens on the cellular kinome profile Open
Background An infection with hepatitis D virus (HDV) is considered the most extreme form of viral hepatitis. Infection with HDV elicits strong increases in inflammation and hepatic injury, therefore pushing liver cirrhosis and development …
View article: Impaired <scp>HBsAg</scp> release and antiproliferative/antioxidant cell regulation by <scp>HBeAg</scp>‐negative patient isolates reflects an evolutionary process
Impaired <span>HBsAg</span> release and antiproliferative/antioxidant cell regulation by <span>HBeAg</span>‐negative patient isolates reflects an evolutionary process Open
Background The hepatitis B e antigen (HBeAg)‐negative infection Phase 3 is characterized by no or minimal signs of hepatic inflammation and the absence of hepatic fibrosis. However, underlying molecular mechanisms leading to this benign ph…
View article: Cellular Factors Involved in the Hepatitis D Virus Life Cycle
Cellular Factors Involved in the Hepatitis D Virus Life Cycle Open
Hepatitis D virus (HDV) is a defective RNA virus with a negative-strand RNA genome encompassing less than 1700 nucleotides. The HDV genome encodes only for one protein, the hepatitis delta antigen (HDAg), which exists in two forms acting a…
View article: The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion
The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion Open
View article: The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion
The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion Open
Ebola viruses (EBOVs) are filamentous particles, whose shape and stability are determined by the VP40 matrix. Virus entry into host cells occurs via membrane fusion in late endosomes; however, the mechanism of how the remarkably long virio…