Kees L. M. C. Franken
YOU?
Author Swipe
View article: Conformation of HLA-E/peptide complex guides interaction with two novel HLA-E receptors: Stabilin 1 and 2
Conformation of HLA-E/peptide complex guides interaction with two novel HLA-E receptors: Stabilin 1 and 2 Open
Human leukocyte antigen E (HLA-E) communicates cellular health to natural killer (NK) cells through presentation of peptides derived from the leader sequence of classical major histocompatibility complex class I (MHC-I), inhibiting NK cell…
View article: Distinct antibody-based signatures and functionality distinguish latent and active pediatric tuberculosis
Distinct antibody-based signatures and functionality distinguish latent and active pediatric tuberculosis Open
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is among the leading causes of death from an infectious agent among children worldwide. Children represent a particularly vulnerable population due to the greater ch…
View article: Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C
Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C Open
T cell recognition of specific antigens presented by major histocompatibility complexes class-I (MHC-I) can play an important role during immune responses against pathogens and cancer cells. Detection of T cell immunity is based on assessi…
View article: Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C
Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C Open
T cell recognition of specific antigens presented by major histocompatibility complexes class-I (MHC-I) can play an important role during immune responses against pathogens and cancer cells. Detection of T cell immunity is based on assessi…
View article: HLA-E/peptide complexes differentially interact with NKG2A/CD94 and T cell receptors
HLA-E/peptide complexes differentially interact with NKG2A/CD94 and T cell receptors Open
The virtually monomorphic antigen presentation molecule HLA-E can present self- and non-self peptides to the NKG2A/CD94 co-receptor inhibitory complex expressed on natural killer (NK) cells and to T cell receptors (TCRs) expressed on T cel…
View article: Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement
Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement Open
View article: The role of IgA and IgG in <i>Mycobacterium tuberculosis</i> infection: A cross-sectional study in Ethiopia
The role of IgA and IgG in <i>Mycobacterium tuberculosis</i> infection: A cross-sectional study in Ethiopia Open
Introduction Despite the high global prevalence of Mycobacterium tuberculosis (Mtb) infection in humans, most infected individuals achieve a stable immunological equilibrium, without showing clinical signs and symptoms of tuberculosis (TB)…
View article: Anti-phenolic glycolipid antibodies in Mycobacterium bovis infected cattle
Anti-phenolic glycolipid antibodies in Mycobacterium bovis infected cattle Open
View article: Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C
Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C Open
T cell recognition of specific antigens presented by major histocompatibility complexes class-I (MHC-I) can play an important role during immune responses against pathogens and cancer cells. Detection of T cell immunity is based on assessi…
View article: HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection
HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection Open
Introduction Tuberculosis (TB) is the deadliest infectious disease worldwide and novel vaccines are urgently needed. HLA-E is a virtually monomorphic antigen presentation molecule and is not downregulated upon HIV co-infection. HLA-E restr…
View article: Intradermal versus subcutaneous immunization: Effects of administration route using a lipid-PLGA hybrid nanoparticle tuberculosis vaccine
Intradermal versus subcutaneous immunization: Effects of administration route using a lipid-PLGA hybrid nanoparticle tuberculosis vaccine Open
View article: Evaluation of PLGA, lipid-PLGA hybrid nanoparticles, and cationic pH-sensitive liposomes as tuberculosis vaccine delivery systems in a Mycobacterium tuberculosis challenge mouse model – A comparison
Evaluation of PLGA, lipid-PLGA hybrid nanoparticles, and cationic pH-sensitive liposomes as tuberculosis vaccine delivery systems in a Mycobacterium tuberculosis challenge mouse model – A comparison Open
Tuberculosis (TB) continues to pose a global threat for millennia, currently affecting over 2 billion people and causing 10.6 million new cases and 1.3 million deaths annually. The only existing vaccine, Mycobacterium Bovis Bacillus Calmet…
View article: Mtb-Specific HLA-E-Restricted T Cells Are Induced during Mtb Infection but Not after BCG Administration in Non-Human Primates and Humans
Mtb-Specific HLA-E-Restricted T Cells Are Induced during Mtb Infection but Not after BCG Administration in Non-Human Primates and Humans Open
Background: Novel vaccines targeting the world’s deadliest pathogen Mycobacterium tuberculosis (Mtb) are urgently needed as the efficacy of the Bacillus Calmette–Guérin (BCG) vaccine in its current use is limited. HLA-E is a virtually mono…
View article: <i>Mtb</i>specific HLA-E restricted T cells are induced during<i>Mtb</i>infection but not after BCG administration in non-human primates and humans
<i>Mtb</i>specific HLA-E restricted T cells are induced during<i>Mtb</i>infection but not after BCG administration in non-human primates and humans Open
Novel vaccines targeting the world’s deadliest pathogen Mycobacterium tuberculosis ( Mtb ) are urgently needed as the efficacy of the Bacillus Calmette–Guérin (BCG) vaccine in its current use is limited. HLA-E is a virtually monomorphic un…
View article: Cationic pH-sensitive liposome-based subunit tuberculosis vaccine induces protection in mice challenged with Mycobacterium tuberculosis
Cationic pH-sensitive liposome-based subunit tuberculosis vaccine induces protection in mice challenged with Mycobacterium tuberculosis Open
Tuberculosis (TB) has been and still is a global emergency for centuries. Prevention of disease through vaccination would have a major impact on disease prevalence, but the only available current vaccine, BCG, has insufficient impact. In t…
View article: Inhibiting the NADase CD38 improves cytomegalovirus-specific CD8+ T cell functionality and metabolism
Inhibiting the NADase CD38 improves cytomegalovirus-specific CD8+ T cell functionality and metabolism Open
Cytomegalovirus (CMV) is one of the most common and relevant opportunistic pathogens in people who are immunocompromised, such as kidney transplant recipients (KTRs). The exact mechanisms underlying the disability of cytotoxic T cells to p…
View article: Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire
Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire Open
View article: The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent Open
View article: Corrigendum: Defining discriminatory antibody fingerprints in active and latent tuberculosis
Corrigendum: Defining discriminatory antibody fingerprints in active and latent tuberculosis Open
[This corrects the article DOI: 10.3389/fimmu.2022.856906.].
View article: Maternal HIV infection drives altered placental Mtb-specific antibody transfer
Maternal HIV infection drives altered placental Mtb-specific antibody transfer Open
Introduction Placental transfer of maternal antibodies is essential for neonatal immunity over the first months of life. In the setting of maternal HIV infection, HIV-exposed uninfected (HEU) infants are at higher risk of developing severe…
View article: Supplementary Figure 1 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
Supplementary Figure 1 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy Open
PDF file - 5666K
View article: Data from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
Data from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy Open
Purpose: To predict the potential antitumor effect of antigen-specific T cells in melanoma patients, we investigated T-cell effector function in relation to tumor-escape mechanisms.Experimental Design: CD8+ T cells…
View article: Supplementary Figure 2 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
Supplementary Figure 2 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy Open
PDF file - 4689K
View article: Supplementary Figure 1 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
Supplementary Figure 1 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy Open
PDF file - 5666K
View article: Supplementary Figure 2 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
Supplementary Figure 2 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy Open
PDF file - 4689K
View article: Data from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
Data from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy Open
Purpose: To predict the potential antitumor effect of antigen-specific T cells in melanoma patients, we investigated T-cell effector function in relation to tumor-escape mechanisms.Experimental Design: CD8+ T cells…
View article: Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice
Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice Open
Viral-vectored vaccines are highly amenable for respiratory mucosal delivery as a means of inducing much-needed mucosal immunity at the point of pathogen entry. Unfortunately, current monovalent viral-vectored tuberculosis (TB) vaccine can…
View article: OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum
OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum Open
View article: T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection Open
Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against Mycobacterium tuberculosis , but the ability to broadly study these responses has been limited. In the present study, we used single-cell and bulk T …
View article: The MHC-E Peptide Ligand of Checkpoint NKG2A Is Governed by Inflammatory Signals and High Turnover
The MHC-E Peptide Ligand of Checkpoint NKG2A Is Governed by Inflammatory Signals and High Turnover Open