Keesha Powell-Roach
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View article: Association of low annexin A2 levels with venous thromboembolism in sickle cell anemia: A potential biomarker
Association of low annexin A2 levels with venous thromboembolism in sickle cell anemia: A potential biomarker Open
Introduction Sickle cell disease (SCD) is an inherited blood disorder that affects millions of individuals worldwide. It is referred to as a hypercoagulable state and patients are at risk for multiple thrombotic complications including ven…
View article: Platelet proteomic signatures reveal neurodegenerative and mitochondrial pathways associated with pain phenotypes in sickle cell disease
Platelet proteomic signatures reveal neurodegenerative and mitochondrial pathways associated with pain phenotypes in sickle cell disease Open
Background: Sickle cell disease (SCD) is a complex hematologic disorder marked by chronic pain and neurocognitive impairments. While these complications are well-documented, the biological mechanisms driving them remain elusive. Platelets,…
View article: Methods to modernize a multimedia, web-based reproductive health education intervention for individuals with sickle cell disease or trait using virtual human narration and user-centered design
Methods to modernize a multimedia, web-based reproductive health education intervention for individuals with sickle cell disease or trait using virtual human narration and user-centered design Open
Objectives: For a population that lacks genetic inheritance knowledge about sickle cell disease/trait, a previously innovative web-based intervention showed significant and sustained knowledge improvement, but current users judged it as “d…
View article: Link Your Large Health Data Sets to the Area Deprivation Index, the ezADI Way
Link Your Large Health Data Sets to the Area Deprivation Index, the ezADI Way Open
Increasing attention has been paid to investigations on how social determinants of health (SDOH; e.g., income, employment, education, housing, etc.) impact health outcomes. However, these variables are often not collected in routine clinic…
View article: SCD Nursing Education: A Scoping Review
SCD Nursing Education: A Scoping Review Open
SCD is a rare, inherited blood disorder that disproportionately affects Black patients. Individuals living with SCD experience significant pain crises and complications due to the sickling of red blood cells. These pain crises cause compli…
View article: Epigenetic Clocks and Accelerated Aging in Sickle Cell Disease
Epigenetic Clocks and Accelerated Aging in Sickle Cell Disease Open
Introduction: Sickle cell disease (SCD) is a hereditary hemoglobinopathy caused by a single point mutation in the β-globin gene. HbS polymerizes under deoxygenated conditions, causing red blood cells to assume a sickle shape, leading to he…
View article: Health-Related Communication in Adolescents and Young Adults with Sickle Cell Disease
Health-Related Communication in Adolescents and Young Adults with Sickle Cell Disease Open
Introduction: Sickle cell disease (SCD) is a genetic condition with multiple acute and chronic health complications, including pain, stroke, and organ damage. Health-related communication between patients, and both others (e.g., family mem…
View article: Annexin A2 As a Potential Biomarker for Venous Thromboembolism in Sickle Cell Anemia
Annexin A2 As a Potential Biomarker for Venous Thromboembolism in Sickle Cell Anemia Open
Introduction Sickle cell disease (SCD) is an inherited blood disorder that affects about 100,000 individuals in the United States (U.S.). It is referred to as a hypercoagulable state and is characterized by the occurrence of multiple compl…
View article: How Masculinity Impedes African American Men From Seeking Mental Health Treatment
How Masculinity Impedes African American Men From Seeking Mental Health Treatment Open
This study addresses the pronounced mental health disparities faced by African American men, characterized by the heightened severity of mental health conditions and their reluctance to seek mental health treatment. Persistent neglect towa…
View article: CHOICES for sickle cell reproductive health: A protocol of a randomized preconception intervention model for a single gene disorder
CHOICES for sickle cell reproductive health: A protocol of a randomized preconception intervention model for a single gene disorder Open
Our long-term goal is to foster genetically informed reproductive health knowledge and behaviors among young adults with sickle cell disease (SCD) or sickle cell trait (SCT) with a web-based, tailored, multimedia intervention called CHOICE…
View article: Single nucleotide polymorphisms and sickle cell disease-related pain: a systematic review
Single nucleotide polymorphisms and sickle cell disease-related pain: a systematic review Open
Background Scientists have speculated genetic variants may contribute to an individual's unique pain experience. Although research exists regarding the relationship between single nucleotide polymorphisms and sickle cell disease-related pa…
View article: Perceptions of Palliative Care: Demographics and Health Status Among the General Population in Florida and the United States
Perceptions of Palliative Care: Demographics and Health Status Among the General Population in Florida and the United States Open
Background Palliative care (PC) helps maintain quality of life for seriously ill patients, yet, many Americans lack knowledge of PC. Aim To explore the relationships between knowledge of PC of individuals living in north-central Florida an…
View article: Analysis of AVPR1A, thermal and pressure pain thresholds, and stress in sickle cell disease
Analysis of AVPR1A, thermal and pressure pain thresholds, and stress in sickle cell disease Open
Aim In patients with sickle cell disease (SCD), negative physical and emotional experiences result from intense chronic and acute pain episodes, but factors underlying these, and their interactions, are not well understood. The arginine va…
View article: P-079: AVPR1A AND STRESS IN YOUNGER AND OLDER ADULTS WITH CHRONIC PAIN OF SICKLE CELL DISEASE
P-079: AVPR1A AND STRESS IN YOUNGER AND OLDER ADULTS WITH CHRONIC PAIN OF SICKLE CELL DISEASE Open
Purpose: Background: In patients with sickle cell disease (SCD), pain results in varied physical and emotional consequences. Insufficient information about underlying mechanisms affecting pain remains a barrier to addressing SCD pain. Mult…
View article: Developing the Florida Academic Cancer Center Alliance Health Disparities Common Measure: The Florida Health and Ancestry Survey
Developing the Florida Academic Cancer Center Alliance Health Disparities Common Measure: The Florida Health and Ancestry Survey Open
Purpose Our specific aim was to develop and assess the consensus-based validity of common measures for understanding health behaviors and ancestry in Florida’s population subgroups and establish the feasibility of wide-scale implementation…
View article: HUMAN STUDY <i>COMT</i> and <i>DRD3</i> haplotype-associated pain intensity and acute care utilization in adult sickle cell disease
HUMAN STUDY <i>COMT</i> and <i>DRD3</i> haplotype-associated pain intensity and acute care utilization in adult sickle cell disease Open
A previous exploratory analysis of a COMT gene single-nucleotide polymorphism (SNP) and a DRD3 SNP by our group suggested possible contributions to pain-related acute care utilization in people with sickle cell disease (SCD). Our aim was t…
View article: Using champion-oriented mindset to overcome the challenges of graduate school: impact of workshop for graduate school skills on underrepresented minority retention
Using champion-oriented mindset to overcome the challenges of graduate school: impact of workshop for graduate school skills on underrepresented minority retention Open
Despite efforts to increase diversity, a glaring underrepresentation of minorities (URM) persists in the fields of science, technology, engineering, and mathematics (STEM). Graduate school can be a stressful step in the STEM pipeline, espe…
View article: Frequency of Cannabis Use and Pain Intensity: Results from a National Sample
Frequency of Cannabis Use and Pain Intensity: Results from a National Sample Open
Background: Chronic pain has become a leading public health concern with roughly 20% of Americans currently living with chronic pain. Individuals living with chronic pain are more likely to report lower quality of life, additional comorbid…
View article: The role of mentoring in promoting diversity equity and inclusion in STEM Education and Research
The role of mentoring in promoting diversity equity and inclusion in STEM Education and Research Open
The success of mentoring derives from active and respectful listening and the willingness to learn and accept opportunities for personal growth. This shapes every trainee and their destined path in science, technology, engineering, and mat…
View article: An effective workshop on “How to be an Effective Mentor for Underrepresented STEM Trainees”
An effective workshop on “How to be an Effective Mentor for Underrepresented STEM Trainees” Open
Despite an increase in programming to promote persons excluded by their ethnicity or race (PEER) scholars, minorities remain underrepresented in many STEM programs. The academic pipeline is largely leaky for underrepresented minority (URM)…
View article: Managing osteoarthritis pain with smart technology: a narrative review
Managing osteoarthritis pain with smart technology: a narrative review Open
Osteoarthritis (OA) is a highly prevalent musculoskeletal condition worldwide. More than 300 million individuals are affected by OA, and pain is the most common and challenging symptom to manage. Although many new advances have led to impr…