Kehan Wang
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View article: CRL2LRRC41-Mediated DDX5 Ubiquitination Enhances Interaction with ELAVL1 Preventing NOG mRNA Degradation and Sustaining Proliferation and Migration of Human Spermatogonial Stem Cell-Like Cell Line
CRL2LRRC41-Mediated DDX5 Ubiquitination Enhances Interaction with ELAVL1 Preventing NOG mRNA Degradation and Sustaining Proliferation and Migration of Human Spermatogonial Stem Cell-Like Cell Line Open
This study provides the first identification of the CRL2LRRC41 complex in human SSCLCs and elucidates the molecular mechanisms by which CRL2LRRC41 facilitates SSCLC function via ubiquitination-mediated protein interactions. These findings …
View article: Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network
Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network Open
Intrahepatic cholangiocarcinoma (iCCA) is a malignancy with difficult treatment and poor prognosis, whose pathogenesis could be associated with the expression patterns of circular RNAs (circRNAs). Here, we aim to investigate the effects an…
View article: Innovative nanoparticle-based therapeutic strategies against glioblastoma multiform: a focus on enhanced delivery systems and efficacy
Innovative nanoparticle-based therapeutic strategies against glioblastoma multiform: a focus on enhanced delivery systems and efficacy Open
Glioblastoma multiforme (GBM) is an exceedingly aggressive primary brain neoplasm characterized by a dismal prognosis owing to its invasiveness, heterogeneity, and immunity to conventional therapies. Conventional therapies, including surge…
View article: <scp>RNF187</scp> Facilitates Proliferation and Migration of Human Spermatogonial Stem Cells Through <scp>WDR77</scp> Polyubiquitination
<span>RNF187</span> Facilitates Proliferation and Migration of Human Spermatogonial Stem Cells Through <span>WDR77</span> Polyubiquitination Open
The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING finger family. RNF187 is indispensable for the proliferation and migration of GC‐1 cells derived from mouse spermatogonia and GC‐2 cells d…
View article: Uncertainty Aware Human-machine Collaboration in Camouflaged Object Detection
Uncertainty Aware Human-machine Collaboration in Camouflaged Object Detection Open
Camouflaged Object Detection (COD), the task of identifying objects concealed within their environments, has seen rapid growth due to its wide range of practical applications. A key step toward developing trustworthy COD systems is the est…
View article: Progranulin protects against <i>Clostridioides difficile</i> infection by enhancing IL-22 production
Progranulin protects against <i>Clostridioides difficile</i> infection by enhancing IL-22 production Open
Enhanced mortality, relapse rates, and increased prevalence of Clostridioides difficile infection (CDI) emphasize the need for better therapies and management approaches. Modulating host immune response to ameliorate CDI-associated immunop…
View article: VPS34 Governs Oocyte Developmental Competence by Regulating Mito/Autophagy: A Novel Insight into the Significance of RAB7 Activity and Its Subcellular Location
VPS34 Governs Oocyte Developmental Competence by Regulating Mito/Autophagy: A Novel Insight into the Significance of RAB7 Activity and Its Subcellular Location Open
Asynchronous nuclear and cytoplasmic maturation in human oocytes is believed to cause morphological anomalies after controlled ovarian hyperstimulation. Vacuolar protein sorting 34 (VPS34) is renowned for its pivotal role in regulating aut…
View article: [Microwave Heartprint: A novel non-contact human identification technology based on cardiac micro-motion detection using ultra wideband bio-radar].
[Microwave Heartprint: A novel non-contact human identification technology based on cardiac micro-motion detection using ultra wideband bio-radar]. Open
The existing one-time identity authentication technology cannot continuously guarantee the legitimacy of user identity during the whole human-computer interaction session, and often requires active cooperation of users, which seriously lim…
View article: Effect of n-C-S-H on Hydration and Reinforcement of Mineral Powder-Cement System at Low Temperatures
Effect of n-C-S-H on Hydration and Reinforcement of Mineral Powder-Cement System at Low Temperatures Open
This paper investigated the effect of nano-calcium silicate hydrate (n-C-S-H) on the early compressive strength of mineral powder-cement systems under low-temperature curing conditions (5 °C). The hydration mechanism of n-C-S-H in the mine…
View article: EB-YOLOX:A Balanced One-Stage Object Detection Model Concentrating on Global Features
EB-YOLOX:A Balanced One-Stage Object Detection Model Concentrating on Global Features Open
With the increasing complexity of objects and the limitation of hardware resources, it is crucial to design object detection models that are both highly effective and efficient. Although YOLOX, as a leading object detector, strikes a good …
View article: Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin)
Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin) Open
Sertoli cells are highly polarized testicular cells that provide a nurturing environment for germ cell development and maturation during spermatogenesis. The class III phosphatidylinositol 3-kinase (PtdIns3K) plays core roles in macroautop…
View article: TIG-DETR: Enhancing Texture Preservation and Information Interaction for Target Detection
TIG-DETR: Enhancing Texture Preservation and Information Interaction for Target Detection Open
FPN (Feature Pyramid Network) and transformer-based target detectors are commonly employed in target detection tasks. However, these approaches suffer from design flaws that restrict their performance. To overcome these limitations, we pro…
View article: TIG-DETR: Enhancing Texture Preservation and Information Interaction for Target Detection
TIG-DETR: Enhancing Texture Preservation and Information Interaction for Target Detection Open
In practical applications, the detection of objects with various sizes is a common requirement for most detectors. The feature pyramid network (FPN) is widely adopted as a framework to address this challenge. The field is witnessing an inc…
View article: Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin)
Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin) Open
Sertoli cells are highly polarized testicular cells that provide a nurturing environment for germ cell development and maturation during spermatogenesis. The class III phosphatidylinositol 3-kinase (PtdIns3K) plays core roles in macroautop…
View article: hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice
hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice Open
Anti-cancer therapy often causes premature ovarian insufficiency and infertility as the ovarian follicle reserve is extremely sensitive to chemotherapy drugs, such as cisplatin. Various fertility preservation methods have been explored for…
View article: Deep Learning Assisted Optimization for 3D Reconstruction from Single 2D Line Drawings
Deep Learning Assisted Optimization for 3D Reconstruction from Single 2D Line Drawings Open
In this paper, we revisit the long-standing problem of automatic reconstruction of 3D objects from single line drawings. Previous optimization-based methods can generate compact and accurate 3D models, but their success rates depend heavil…
View article: Neural Face Identification in a 2D Wireframe Projection of a Manifold Object
Neural Face Identification in a 2D Wireframe Projection of a Manifold Object Open
In computer-aided design (CAD) systems, 2D line drawings are commonly used to illustrate 3D object designs. To reconstruct the 3D models depicted by a single 2D line drawing, an important key is finding the edge loops in the line drawing w…
View article: Misinformation Detection in Social Media Video Posts
Misinformation Detection in Social Media Video Posts Open
With the growing adoption of short-form video by social media platforms, reducing the spread of misinformation through video posts has become a critical challenge for social media providers. In this paper, we develop methods to detect misi…
View article: Negative or Positive? Loading Area Dependent Correlation Between Friction and Normal Load in Structural Superlubricity
Negative or Positive? Loading Area Dependent Correlation Between Friction and Normal Load in Structural Superlubricity Open
Structural superlubricity (SSL), a state of ultra-low friction between two solid contacts, is a fascinating phenomenon in modern tribology. With extensive molecular dynamics simulations, for systems showing SSL, here we discover two differ…
View article: Composing MPC with LQR and Neural Network for Amortized Efficiency and Stable Control
Composing MPC with LQR and Neural Network for Amortized Efficiency and Stable Control Open
Model predictive control (MPC) is a powerful control method that handles dynamical systems with constraints. However, solving MPC iteratively in real time, i.e., implicit MPC, remains a computational challenge. To address this, common solu…
View article: Fast, Accurate Barcode Detection in Ultra High-Resolution Images
Fast, Accurate Barcode Detection in Ultra High-Resolution Images Open
Object detection in Ultra High-Resolution (UHR) images has long been a challenging problem in computer vision due to the varying scales of the targeted objects. When it comes to barcode detection, resizing UHR input images to smaller sizes…
View article: RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging
RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging Open
There is increasing evidence that mitophagy, a specialized form of autophagy to degrade and clear long-lived or damaged mitochondria, is impaired in aging and age-related disease. Previous study has demonstrated the obesity-exposed oocytes…
View article: Multi-Modal Semantic Inconsistency Detection in Social Media News Posts
Multi-Modal Semantic Inconsistency Detection in Social Media News Posts Open
As computer-generated content and deepfakes make steady improvements, semantic approaches to multimedia forensics will become more important. In this paper, we introduce a novel classification architecture for identifying semantic inconsis…
View article: RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging
RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging Open
There is increasing evidence that mitophagy, a specialized form of autophagy to degrade and clear long-lived or damaged mitochondria, is impaired in aging and age-related disease. Previous study has demonstrated the obesity-exposed oocytes…
View article: Correction: Surface characterization of maize-straw-derived biochar and their sorption mechanism for Pb2+ and methylene blue
Correction: Surface characterization of maize-straw-derived biochar and their sorption mechanism for Pb2+ and methylene blue Open
[This corrects the article DOI: 10.1371/journal.pone.0238105.].
View article: Surface characterization of maize-straw-derived biochar and their sorption mechanism for Pb2+ and methylene blue
Surface characterization of maize-straw-derived biochar and their sorption mechanism for Pb2+ and methylene blue Open
Biochar derived from straw is a potential low-cost adsorbent for metal ions and organic pollutants, but its practical application is still limited by the adsorption capacity. In this study, the correlation between the biochar's properties …
View article: Alumina Extraction from Coal Fly Ash via Low-Temperature Potassium Bisulfate Calcination
Alumina Extraction from Coal Fly Ash via Low-Temperature Potassium Bisulfate Calcination Open
Owing to the depletion of bauxite and increasing demand for alumina, calcination methods for extracting alumina from coal fly ash (CFA) were developed. However, these methods have disadvantages such as the need for high temperatures and th…