Kehui Xiang
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View article: 5′ untranslated regions tune <i>Toxoplasma</i> translation
5′ untranslated regions tune <i>Toxoplasma</i> translation Open
Some of the longest 5′ untranslated regions (UTRs) documented in eukaryotes belong to parasites of the phylum Apicomplexa. Translational regulation plays prominent roles in the development of these parasites, including the agents of toxopl…
View article: Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis
Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis Open
Background The Bacillus genus is well known for producing structurally diverse lipopeptides, many of which exhibit remarkable surface-active and bioactive properties, such as surfactin and daptomycin. In recent years, genome mining has eme…
View article: PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility
PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility Open
In oocytes of mammals and other animals, gene regulation is mediated primarily through changes in poly(A)-tail length 1–9 . Here, we introduce PAL-AI, an integrated neural network machine-learning model that accurately predicts tail-length…
View article: Nuclear release of eIF1 globally increases stringency of start-codon selection to preserve mitotic arrest physiology
Nuclear release of eIF1 globally increases stringency of start-codon selection to preserve mitotic arrest physiology Open
Regulated start-codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start-codon selection is al…
View article: Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos
Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos Open
During oocyte maturation and early embryogenesis, changes in mRNA poly(A)-tail lengths strongly influence translation, but how these tail-length changes are orchestrated has been unclear. Here, we performed tail-length and translational pr…
View article: Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos
Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos Open
SUMMARY During oocyte maturation and early embryogenesis, changes in mRNA poly(A)-tail lengths strongly influence translation, but how these tail-length changes are orchestrated has been unclear. Here, we performed tail-length and translat…
View article: The molecular basis of coupling between poly(A)-tail length and translational efficiency
The molecular basis of coupling between poly(A)-tail length and translational efficiency Open
In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development this coupling between tail length and TE disappears. Here, we elucidate how this coupling is first es…
View article: Author response: The molecular basis of coupling between poly(A)-tail length and translational efficiency
Author response: The molecular basis of coupling between poly(A)-tail length and translational efficiency Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In animal oocytes and early e…
View article: The molecular basis of coupling between poly(A)-tail length and translational efficiency
The molecular basis of coupling between poly(A)-tail length and translational efficiency Open
In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development this coupling between tail length and TE disappears. Here, we elucidate how this coupling is first es…