Kei E. Fujimura
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View article: Early-life nasal microbiota dynamics relate to longitudinal respiratory phenotypes in urban children
Early-life nasal microbiota dynamics relate to longitudinal respiratory phenotypes in urban children Open
View article: Precocious infant fecal microbiome promotes enterocyte barrier dysfuction, altered neuroendocrine signaling and associates with increased childhood obesity risk
Precocious infant fecal microbiome promotes enterocyte barrier dysfuction, altered neuroendocrine signaling and associates with increased childhood obesity risk Open
Early life gut microbiome composition has been correlated with childhood obesity, though microbial functional contributions to disease origins remain unclear. Here, using an infant birth cohort (n = 349) we identify a distinct fecal…
View article: Supplementary Material for: In utero exposure to valproic acid throughout pregnancy causes phenotypes of autism in offspring mice
Supplementary Material for: In utero exposure to valproic acid throughout pregnancy causes phenotypes of autism in offspring mice Open
Valproic acid (VPA) is an antiepileptic drug that inhibits the epileptic activity of neurons mainly by inhibiting sodium channels and GABA transaminase. VPA is also known to inhibit histone deacetylases, which epigenetically modify the cel…
View article: Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy
Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy Open
Maternal asthma status, prenatal exposures, and infant gut microbiota perturbation are associated with heightened risk of atopy and asthma risk in childhood, observations hypothetically linked by intergenerational microbial transmission. U…
View article: Maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development
Maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development Open
Background The path to childhood asthma is thought to initiate in utero and be further promoted by postnatal exposures. However, the underlying mechanisms remain underexplored. We hypothesized that prenatal maternal immune dysfunction asso…
View article: Infant gut bacterial community composition and food‐related manifestation of atopy in early childhood
Infant gut bacterial community composition and food‐related manifestation of atopy in early childhood Open
Background Immunoglobulin E–mediated food allergy (IgE‐FA) has emerged as a global public health concern. Immune dysregulation is an underlying mechanism for IgE‐FA, caused by “dysbiosis” of the early intestinal microbiota. We investigated…
View article: Maternal gut microbiome regulates immunity to RSV infection in offspring
Maternal gut microbiome regulates immunity to RSV infection in offspring Open
Development of the immune system can be influenced by diverse extrinsic and intrinsic factors that influence the risk of disease. Severe early life respiratory syncytial virus (RSV) infection is associated with persistent immune alteration…
View article: Gut microbiome is associated with multiple sclerosis activity in children
Gut microbiome is associated with multiple sclerosis activity in children Open
Objective To identify features of the gut microbiome associated with multiple sclerosis activity over time. Methods We used 16S ribosomal RNA sequencing from stool of 55 recently diagnosed pediatric‐onset multiple sclerosis patients. Micro…
View article: Corroborating evidence refutes batch effect as explanation for fetal bacteria
Corroborating evidence refutes batch effect as explanation for fetal bacteria Open
View article: Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study
Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study Open
View article: Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers Open
As microbial therapeutics are increasingly being tested in diverse patient populations, it is essential to understand the host and environmental factors influencing the microbiome. Through analysis of 1,359 gut microbiome samples from 946 …
View article: Early life RSV infection in neonatal mice leads to exacerbated allergic asthma due to persistent Th2 pulmonary responses that are abrogated by maternal supplementation with a L. johnsonii probiotic
Early life RSV infection in neonatal mice leads to exacerbated allergic asthma due to persistent Th2 pulmonary responses that are abrogated by maternal supplementation with a L. johnsonii probiotic Open
The development of immune responses in infants is central to establishing a balanced system that reacts appropriately to infectious stimuli but does not induce altered disease states with potential long term sequelae. Studies have linked s…
View article: The early life trajectory of infant gut microbiota and atopic asthma at 10 years-of-age in a US birth cohort
The early life trajectory of infant gut microbiota and atopic asthma at 10 years-of-age in a US birth cohort Open
View article: Gut Microbiome Derived 12,13 Dihome Promotes Antigen Presenting Cell Dysfunction In Vitro and Airway Allergic Inflammation In Vivo
Gut Microbiome Derived 12,13 Dihome Promotes Antigen Presenting Cell Dysfunction In Vitro and Airway Allergic Inflammation In Vivo Open
View article: Viable bacterial colonization is highly limited in the human intestine in utero
Viable bacterial colonization is highly limited in the human intestine in utero Open
View article: Epigenetic trajectories linking the maternal prenatal immune profile and risk for childhood asthma
Epigenetic trajectories linking the maternal prenatal immune profile and risk for childhood asthma Open
View article: Stability and dynamics of the human gut microbiome and its association with systemic immune traits
Stability and dynamics of the human gut microbiome and its association with systemic immune traits Open
Summary Analysis of 1,363 deeply sequenced gut microbiome samples from 946 healthy donors of the Milieu Intérieur cohort provides new opportunities to discover how the gut microbiome is associated with host factors and lifestyle parameters…
View article: Author Correction: Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance
Author Correction: Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance Open
View article: A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis
A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis Open
Microbial dysbiosis commonly occurs in patients with inflammatory bowel diseases (IBD). Exogenous causes of dysbiosis such as antibiotics and diet are well described, but host derived causes are understudied. A20 is a potent regulator of s…
View article: Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma
Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma Open
View article: Neonatal gut-microbiome-derived 12,13 DiHOME suppresses immune tolerance via PPARγ
Neonatal gut-microbiome-derived 12,13 DiHOME suppresses immune tolerance via PPARγ Open
View article: Early-life home environment and risk of asthma among inner-city children
Early-life home environment and risk of asthma among inner-city children Open
View article: Breast Milk Transforming Growth Factor β Is Associated With Neonatal Gut Microbial Composition
Breast Milk Transforming Growth Factor β Is Associated With Neonatal Gut Microbial Composition Open
Background and Objectives: Breast milk is a complex bioactive fluid that varies across numerous maternal and environmental conditions. Although breast‐feeding is known to affect neonatal gut microbiome, the milk components responsible for …
View article: Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation
Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation Open
View article: Evaluation of Indoor Microbiota in Wisconsin Farm Vs. Non-farm Homes Using Electrostatic Dust Collectors
Evaluation of Indoor Microbiota in Wisconsin Farm Vs. Non-farm Homes Using Electrostatic Dust Collectors Open
View article: The childhood asthma-associated metabolite 12,13 DiHOME, suppresses regulatory T cells
The childhood asthma-associated metabolite 12,13 DiHOME, suppresses regulatory T cells Open
View article: Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity
Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity Open
The joint impact of pregnancy, environmental, and sociocultural exposures on early life gut microbiome is not yet well-characterized, especially in racially and socioeconomically diverse populations. Gut microbiota of 298 children from a D…
View article: Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome
Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome Open
View article: The Infant Gut Microbiome Mediates the Association Between Breastfeeding and Allergic-like Response to Pets in Children
The Infant Gut Microbiome Mediates the Association Between Breastfeeding and Allergic-like Response to Pets in Children Open
View article: Breastfeeding Is Associated with Infant Gut Microbial Composition
Breastfeeding Is Associated with Infant Gut Microbial Composition Open