Kaoru Suzuki
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View article: Public perceptions of radioactively contaminated waste resulting from environmental decontamination efforts after a large nuclear accident: a comparison with high-level radioactive waste and industrial waste
Public perceptions of radioactively contaminated waste resulting from environmental decontamination efforts after a large nuclear accident: a comparison with high-level radioactive waste and industrial waste Open
The aim of this study was to gather practical insights into the social aspects of waste disposal following environmental decontamination after a nuclear accident. By comparing decontamination waste with high-level radioactive waste and ind…
View article: The relationship between ruminal mat consistency of calves and mortality or immunity
The relationship between ruminal mat consistency of calves and mortality or immunity Open
Two studies were conducted on the relationship between ruminal mat consistency (RMC) and (1) calf mortality or (2) immunity. Assessment of RMC was by ten repeated manual compressions of the middle rumen; good-RMC showed no fluid bounce-bac…
View article: Subcutaneous Injection Anesthesia Using Alphaxalone to Enable Intraoral Treatment of Degus
Subcutaneous Injection Anesthesia Using Alphaxalone to Enable Intraoral Treatment of Degus Open
デグーの口腔内処置を可能にする注射麻酔法を提案するため,メデトミジン0.2 mg/kgとブトルファノール2.5 mg/kgを麻酔前投薬した後にアルファキサロン7 mg/kgを皮下注射した際の効果を調べた.横臥姿勢に至るまでは約3分と速やかで,その後20分程度続く鎮静効果及び抗侵害受容作用を認めた.酸素マスクを装着した状態であれば経皮的動脈血酸素飽和度(SpO2)はおおむね99%を示し,体温,心拍数,呼吸数及び脈拍数も臨床的に満足のいく範囲内で推移した.次にこの麻酔法で模擬的…
View article: ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease
ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease Open
Despite the routine use of sandwich enzyme-linked immunosorbent assays (ELISAs) for quantifying tau levels in CSF and plasma, tau accumulations in the brains of patients with Alzheimer disease (AD) have rarely been evaluated by this method…
View article: Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion
Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion Open
View article: Upregulated expression of a subset of genes in <i>APP</i>;<i>ob</i>/<i>ob</i> mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease
Upregulated expression of a subset of genes in <i>APP</i>;<i>ob</i>/<i>ob</i> mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease Open
Clinical studies have indicated that obesity and diabetes are associated with Alzheimer's disease (AD) and neurodegeneration. However, the mechanism by which obesity/diabetes and AD interact with each other and contribute to dementia remai…
View article: Characterization of Tau ELISAs&nbsp;for Evaluating Tau Accumulation in the Brains With Alzheimer’s Disease
Characterization of Tau ELISAs for Evaluating Tau Accumulation in the Brains With Alzheimer’s Disease Open
Background: One main pathological hallmark of Alzheimer’s disease (AD) is tau accumulation as neurofibrillary tangles (NFTs) in the brain. Although sandwich enzyme-linked immunosorbent assays (ELISAs) are useful for quantifying tau levels,…
View article: Saline Solution Irrigation of the Bile Duct after Stone Removal Reduces the Recurrence of Common Bile Duct Stones
Saline Solution Irrigation of the Bile Duct after Stone Removal Reduces the Recurrence of Common Bile Duct Stones Open
Common bile duct (CBD) stone is a relatively common but potentially life-threatening disease. Endoscopic sphincterotomy (EST) has been performed as standard therapy for CBD stones, but the rate of recurrence of CBD stones is high. Risk fac…
View article: Interaction between <i>APOE</i> genotype and diabetes in cognitive decline
Interaction between <i>APOE</i> genotype and diabetes in cognitive decline Open
Diabetes accelerates cognitive decline, in part, through accelerating vascular impairment in non-APOE ε4 carriers, but such effects are negligible in APOE4 carriers, who themselves are already vulnerable to vascular impairmen…
View article: Increased levels of Aβ42 decrease the lifespan of <i>ob/ob</i> mice with dysregulation of microglia and astrocytes
Increased levels of Aβ42 decrease the lifespan of <i>ob/ob</i> mice with dysregulation of microglia and astrocytes Open
Clinical studies have indicated that obesity and diabetes are associated with Alzheimer's disease (AD) and neurodegeneration. Although the mechanisms underlying these associations remain elusive, the bidirectional interactions between obes…
View article: P3‐068: INCREASED LEVELS OF Aβ42 DECREASE THE LIFE SPAN OF <i>OB/OB</i> MICE WITH DYSREGULATION OF MICROGLIA AND ASTROCYTES
P3‐068: INCREASED LEVELS OF Aβ42 DECREASE THE LIFE SPAN OF <i>OB/OB</i> MICE WITH DYSREGULATION OF MICROGLIA AND ASTROCYTES Open
Clinical studies have indicated that diabetes is associated with Alzheimer's disease (AD) and neurodegeneration. Although the mechanisms underlying these associations remain elusive, the bidirectional interactions between diabetes and AD m…
View article: Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells
Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells Open
View article: Errata: Economic Evaluation of mFOLFOX6-based First-line Regimens for Unresectable Advanced or Recurrent Colorectal Cancer Using Clinical Decision Analysis
Errata: Economic Evaluation of mFOLFOX6-based First-line Regimens for Unresectable Advanced or Recurrent Colorectal Cancer Using Clinical Decision Analysis Open
Right ↑10 ICER＝ CER of a molecular-targeted drug regimen-CER of FOLFIRI expected lifetime of molecular-targeted drug regimen-expected lifetime of FOLFIRI ICER＝ CER of a molecular-targeted drug regimen-CER of mFOLFOX6 expected lifetime of m…
View article: Tunnel use facilitates handling of ICR mice and decreases experimental variation
Tunnel use facilitates handling of ICR mice and decreases experimental variation Open
We evaluated a handling method using tunnels to tame laboratory mice (ICR) in the context of animal welfare and ease of handling. During 1-week acclimation to handling and subsequent 1-week oral administration (once per day), voluntary int…
View article: Economic Evaluation of mFOLFOX6-based First-line Regimens for Unresectable Advanced or Recurrent Colorectal Cancer Using Clinical Decision Analysis
Economic Evaluation of mFOLFOX6-based First-line Regimens for Unresectable Advanced or Recurrent Colorectal Cancer Using Clinical Decision Analysis Open
We evaluated four representative chemotherapy regimens for unresectable advanced or recurrent KRAS-wild type colorectal cancer: mFOLFOX6, mFOLFOX6+bevacizumab (Bmab), cetuximab (Cmab), or panitumumab (Pmab). We employed a decision analysis…
View article: High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice
High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice Open
SLC19A3 deficiency, also called thiamine metabolism dysfunction syndrome-2 (THMD2; OMIM 607483), is an autosomal recessive neurodegenerative disorder caused by mutations in SLC19A3, the gene encoding thiamine transporter 2. To investigate …
View article: Clinical and molecular genetic characterization of two siblings with trisomy 2p24.3‐pter and monosomy 5p14.3‐pter
Clinical and molecular genetic characterization of two siblings with trisomy 2p24.3‐pter and monosomy 5p14.3‐pter Open
Partial trisomy 2p syndrome is occasionally associated with neural tube defects (NTDs), such as anencephaly, encephalocele, and spina bifida, in addition to common features of intellectual disability, developmental delay, and characteristi…
View article: The prevalence and management of allergic diseases among kindergartens and nurseries in Tokyo
The prevalence and management of allergic diseases among kindergartens and nurseries in Tokyo Open
【研究目的】東京都の保育施設等における園児・児童のアレルギー疾患の罹患状況や施設内体制を調査し, 今後のアレルギー疾患対策の課題を明らかにする.
View article: Effects of inducing exercise on growing mice by means of three-dimensional structure in rearing environment
Effects of inducing exercise on growing mice by means of three-dimensional structure in rearing environment Open
We reared ICR mice during a growth period (3 to 10 weeks of age) and examined the effect of exercise induction, by enriching the rearing environment with obstacles such as ladders, compared to the standard environment. Environmental enrich…