Keiji Fujiwara
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View article: Highly selective SGLT2 inhibitors suppress glucose uptake in alpha-TC1 cells, while glucagon secretion is not affected
Highly selective SGLT2 inhibitors suppress glucose uptake in alpha-TC1 cells, while glucagon secretion is not affected Open
The existence of sodium-glucose cotransporter 2 (SGLT2) in pancreatic alpha cells and its potential roles in glucagon secretion remain controversial, despite its well-established function in renal glucose reabsorption. While some studies s…
View article: Treatment Efficacy and Lung Abnormalities of Amikacin Liposome Inhalation Suspension for Refractory Mycobacterium avium Complex Pulmonary Disease: A Two-Center Retrospective Cohort Study
Treatment Efficacy and Lung Abnormalities of Amikacin Liposome Inhalation Suspension for Refractory Mycobacterium avium Complex Pulmonary Disease: A Two-Center Retrospective Cohort Study Open
Background: The guideline recommends the addition of amikacin liposome inhalation suspension (ALIS) to guideline-based therapy for patients with refractory Mycobacterium avium complex pulmonary disease (MAC-PD). The real-world data on the …
View article: Risk factors, molecular analysis and treatment outcomes of amikacin-resistant <i>Mycobacterium avium</i> complex pulmonary disease
Risk factors, molecular analysis and treatment outcomes of amikacin-resistant <i>Mycobacterium avium</i> complex pulmonary disease Open
Background Although the incidence of amikacin (AMK)-resistant Mycobacterium avium complex (MAC) pulmonary disease (PD) is suspected to have increased, limited data are available on AMK-resistant MAC-PD. This study evaluated the risk factor…
View article: Serodiagnosis of <i>M</i>. <i>abscessus</i> species pulmonary disease using anti-glycopeptidolipid-core IgA antibody
Serodiagnosis of <i>M</i>. <i>abscessus</i> species pulmonary disease using anti-glycopeptidolipid-core IgA antibody Open
View article: Quantifying the Reversibility of Clofazimine-induced Pigmentation in a Patient with <i>Mycobacterium abscessus</i> Pulmonary Disease
Quantifying the Reversibility of Clofazimine-induced Pigmentation in a Patient with <i>Mycobacterium abscessus</i> Pulmonary Disease Open
A 45-year-old woman with Mycobacterium abscessus pulmonary disease was treated with multidrug therapy, including clofazimine, at Fukujuji Hospital. Six months after clofazimine initiation, the treatment was discontinued at the patient's re…
View article: Nontuberculous mycobacterial pulmonary disease caused by <i>Mycobacterium seoulense</i>
Nontuberculous mycobacterial pulmonary disease caused by <i>Mycobacterium seoulense</i> Open
Mycobacterium seoulense was first isolated and reported in Korea in 2007. We report a rare case of nontuberculous mycobacterial (NTM) pulmonary disease caused by M. seoulense . A woman in her mid‐90s was referred to our hospital due to blo…
View article: Distinctive clinical features of radiological pleuroparenchymal fibroelastosis with nontuberculous mycobacterial pulmonary disease: A multicenter retrospective cohort study
Distinctive clinical features of radiological pleuroparenchymal fibroelastosis with nontuberculous mycobacterial pulmonary disease: A multicenter retrospective cohort study Open
NTM-PPFE is a unique NTM-PD phenotype with a poorer prognosis than the NB and FC phenotypes.
View article: <i>In vitro</i> effects of the new oral β-lactamase inhibitor xeruborbactam in combination with oral β-lactams against clinical <i>Mycobacterium abscessus</i> isolates
<i>In vitro</i> effects of the new oral β-lactamase inhibitor xeruborbactam in combination with oral β-lactams against clinical <i>Mycobacterium abscessus</i> isolates Open
Non-tuberculosis mycobacteria (NTM), particularly Mycobacterium abscessus subsp. abscessus ( M. abscessus ), are increasingly being recognized as etiological agents of NTM pulmonary disease. However, treatment options for M. abscessus are …
View article: Usefulness of gastric aspirates for diagnosing nontuberculous mycobacteriosis
Usefulness of gastric aspirates for diagnosing nontuberculous mycobacteriosis Open
View article: <i>In Vitro</i> Synergistic Effects of Omadacycline with Other Antimicrobial Agents against Mycobacterium abscessus
<i>In Vitro</i> Synergistic Effects of Omadacycline with Other Antimicrobial Agents against Mycobacterium abscessus Open
The clinical importance of Mycobacterium abscessus species (MABS) infections has been increasing. However, the standard treatment regimens recommended in the current guidelines often result in unfavorable outcomes.
View article: Causative antigens of humidifier lung in vapor from a humidifier: A case report
Causative antigens of humidifier lung in vapor from a humidifier: A case report Open
View article: Epidemiological characteristics of nontuberculous mycobacteriosis and bronchiectasis: comparative study using national mortality statistics from 1970 to 2015 in Japan
Epidemiological characteristics of nontuberculous mycobacteriosis and bronchiectasis: comparative study using national mortality statistics from 1970 to 2015 in Japan Open
Background This study assessed longitudinal national data on mortality due to nontuberculous mycobacteriosis (NTMosis) and bronchiectasis and the association between the two diseases. Methods We analysed the national death statistics of Ja…
View article: Pharmacokinetics and Adverse Effects of Clofazimine in the Treatment of Pulmonary Non-Tuberculous Mycobacterial Infection
Pharmacokinetics and Adverse Effects of Clofazimine in the Treatment of Pulmonary Non-Tuberculous Mycobacterial Infection Open
Clofazimine (CFZ) is used to treat pulmonary non-tuberculous mycobacterial (NTM) infection; however, its pharmacokinetics remain unexplored in patients with pulmonary NTM, and the relationship between CFZ serum concentration and adverse ef…
View article: Analysis of risk factors for pulmonary tuberculosis with persistent severe inflammation
Analysis of risk factors for pulmonary tuberculosis with persistent severe inflammation Open
Introduction: Patients with pulmonary tuberculosis (TB) sometimes show persistent severe inflammation for more than 1 month, even if TB treatment is effective. Although this inflammation can be improved through continuous antituberculous t…
View article: Potential Cross-Transmission of Mycobacterium abscessus among Non-Cystic Fibrosis Patients at a Tertiary Hospital in Japan
Potential Cross-Transmission of Mycobacterium abscessus among Non-Cystic Fibrosis Patients at a Tertiary Hospital in Japan Open
IMPORTANCE Although the possibility of Mycobacterium abscessus ( M. abscessus ) cross-transmission in cystic fibrosis (CF) patients has often been reported, it is not clear whether similar events have occurred in Asian non-CF patients. Who…
View article: Molecular Epidemiological Characteristics of Mycobacterium abscessus Complex Derived from Non-Cystic Fibrosis Patients in Japan and Taiwan
Molecular Epidemiological Characteristics of Mycobacterium abscessus Complex Derived from Non-Cystic Fibrosis Patients in Japan and Taiwan Open
Members of Mycobacterium abscessus complex (MABC) are frequently isolated from patients. Studies have reported that predominant clones of MABC (known as dominant circulating clones; DCCs) are distributed worldwide and transmitted from huma…
View article: Molecular epidemiological characteristics of <i>Mycobacterium abscessus</i> complex in non-cystic fibrosis patients in Japan and Taiwan
Molecular epidemiological characteristics of <i>Mycobacterium abscessus</i> complex in non-cystic fibrosis patients in Japan and Taiwan Open
Mycobacterium abscessus complex (MABC) is an emerging non-tuberculous mycobacterium (NTM). Specific MABC clones are reportedly spreading globally in cystic fibrosis (CF) patients, however, associated genomic epidemiology studies are lackin…
View article: Effects of pain on depression, sleep, exercise tolerance, and quality of life in patients with nontuberculous mycobacterial pulmonary disease
Effects of pain on depression, sleep, exercise tolerance, and quality of life in patients with nontuberculous mycobacterial pulmonary disease Open
The experience and causes of pain in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) have not been clarified. This study aimed to determine the prevalence and severity of bodily pain (BP) in patients with NTM-PD. We a…
View article: Waterproofing spray-associated pneumonitis review
Waterproofing spray-associated pneumonitis review Open
Waterproofing spray-associated pneumonitis (WAP) proceeds to acute respiratory failure and is characterized by diffuse bilateral ground-glass opacities on computed tomography; however, the detailed characteristics of WAP are unknown. There…
View article: Table of Contents
Table of Contents Open
View article: Analysis of risk factors for the development of a post-bronchoscopy respiratory infection in lung cancer patients
Analysis of risk factors for the development of a post-bronchoscopy respiratory infection in lung cancer patients Open
Background: The development of pneumonia following bronchoscopy is very important as a post-bronchoscopy complication. Most patients with post-bronchoscopy respiratory infections show typical pneumonia, and lung abscesses are rare. However…
View article: ABSTRACT WITHDRAWN
ABSTRACT WITHDRAWN Open
mucormycosis is an uncommon, life-threatening opportunistic fungal infection which affects immunocompromised patients such as diabetes, recipients of stem cell or organ transplant, and has worse outcomes in those with hematologic malignanc…
View article: Waterproofing spray-associated pneumonitis: review of 29 cases and comparisons with acute eosinophilic pneumonia and hypersensitivity pneumonitis
Waterproofing spray-associated pneumonitis: review of 29 cases and comparisons with acute eosinophilic pneumonia and hypersensitivity pneumonitis Open
Purpose: Waterproofing spray-associated pneumonitis (WAP) proceeds to acute respiratory failure and is characterized by diffuse bilateral ground-glass opacities on computed tomography. These features are similar to those of acute eosinophi…
View article: The Concavity of the Maximal Expiratory Flow–Volume Curve Reflects the Extent of Emphysema in Obstructive Lung Diseases
The Concavity of the Maximal Expiratory Flow–Volume Curve Reflects the Extent of Emphysema in Obstructive Lung Diseases Open
View article: <i>Mycobacterium avium</i> Complex Pleuritis with Elevated Anti-glycopeptidolipid-core IgA Antibody Levels in Pleural Effusion
<i>Mycobacterium avium</i> Complex Pleuritis with Elevated Anti-glycopeptidolipid-core IgA Antibody Levels in Pleural Effusion Open
Pleuritis caused by nontuberculous mycobacteria is uncommon and difficult to diagnose. We herein report a case of Mycobacterium avium complex (MAC) pleuritis with elevated anti-glycopeptidolipid (GPL)-core IgA antibody levels in the pleura…