Keiji Nihei
YOU?
Author Swipe
View article: RADT-19. ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY, A RANDOMIZED CONTROLLED TRIAL FOR REFRACTORY RECURRENT HIGH-GRADE MENINGIOMAS
RADT-19. ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY, A RANDOMIZED CONTROLLED TRIAL FOR REFRACTORY RECURRENT HIGH-GRADE MENINGIOMAS Open
BACKGROUND High-grade meningiomas (HGMs) recurred after X-ray treatment showed pessimistic prognosis. We conducted “A phase II investigator-lead RCT using accelerator-based boron neutron capture therapy (BNCT) system for refractory recurre…
View article: Non‑surgical breast‑conserving treatment using Kochi oxydol‑radiation therapy for unresectable carcinomas II for patients with stage 0 to IIIC breast cancer
Non‑surgical breast‑conserving treatment using Kochi oxydol‑radiation therapy for unresectable carcinomas II for patients with stage 0 to IIIC breast cancer Open
Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas (KORTUC) is a novel radiosensitizing treatment developed in Japan that involves intratumoral injections of hydrogen peroxide (H2O2) and sodium hyaluronate (HA…
View article: Investigation on the efficacy of a tissue equivalent material bolus for BNCT
Investigation on the efficacy of a tissue equivalent material bolus for BNCT Open
Background In radiation therapy, the use of bolus is an effective technique for improving the surface dose. This irradiation technique is also used in BNCT. However, since BNCT uses neutron irradiation, it is important to evaluate both the…
View article: Implementation of a real‐time neutron monitor system for use in routine quality assurance of an accelerator‐based neutron system for clinical boron neutron capture therapy
Implementation of a real‐time neutron monitor system for use in routine quality assurance of an accelerator‐based neutron system for clinical boron neutron capture therapy Open
Background Currently, the metal foil activation method is routinely used to measure the neutron output of an accelerator‐based neutron source designed for clinical Boron neutron capture therapy (BNCT). Although this method is well establis…
View article: Radiotherapy treatment planning for esophageal cancer: JASTRO guidelines 2024 for radiotherapy treatment planning
Radiotherapy treatment planning for esophageal cancer: JASTRO guidelines 2024 for radiotherapy treatment planning Open
The Japanese Society for Radiation Oncology (JASTRO) Guidelines for Radiotherapy Treatment Planning have been revised every four years to incorporate the latest findings since the publication of the first edition in 2004. This is a review …
View article: Contouring atlas and essential points for radiotherapy in rectal cancer
Contouring atlas and essential points for radiotherapy in rectal cancer Open
In the last decade, the role of radiotherapy in rectal cancer has changed significantly with the introduction of total neoadjuvant therapy (TNT) and nonoperative management (NOM). For the setting of irradiation field in rectal cancer, the …
View article: Dummy run study for outlining and plan quality of intensity-modulated radiotherapy in elderly patients with newly diagnosed glioblastoma: The Japan clinical oncology group study JCOG1910 (AgedGlio-PIII)
Dummy run study for outlining and plan quality of intensity-modulated radiotherapy in elderly patients with newly diagnosed glioblastoma: The Japan clinical oncology group study JCOG1910 (AgedGlio-PIII) Open
Several institutions demonstrated deviations in outlining that necessitated revisions. Thus, appropriate feedback and periodic sharing of information with participating institutions is necessary in the upcoming prospective JCOG1910 study.
View article: Comparison of outcomes between surgery and chemoradiotherapy after endoscopic resection for pT1a-MM with lymphovascular invasion or pT1b esophageal squamous cell carcinoma: Japanese multicenter propensity score-matched study
Comparison of outcomes between surgery and chemoradiotherapy after endoscopic resection for pT1a-MM with lymphovascular invasion or pT1b esophageal squamous cell carcinoma: Japanese multicenter propensity score-matched study Open
View article: Clinical evaluation of performance, stability, and longevity of an accelerator system designed for boron neutron capture therapy utilising a beryllium target
Clinical evaluation of performance, stability, and longevity of an accelerator system designed for boron neutron capture therapy utilising a beryllium target Open
View article: Correction: Sato et al. Safety of Boron Neutron Capture Therapy with Borofalan(10B) and Its Efficacy on Recurrent Head and Neck Cancer: Real-World Outcomes from Nationwide Post-Marketing Surveillance. Cancers 2024, 16, 869
Correction: Sato et al. Safety of Boron Neutron Capture Therapy with Borofalan(10B) and Its Efficacy on Recurrent Head and Neck Cancer: Real-World Outcomes from Nationwide Post-Marketing Surveillance. Cancers 2024, 16, 869 Open
The authors wish to make the following corrections to this paper [...]
View article: Implementation of optically simulated luminescent dosimeter for quality control of gamma ray dose of an accelerator‐based neutron source
Implementation of optically simulated luminescent dosimeter for quality control of gamma ray dose of an accelerator‐based neutron source Open
Background Neutron beams utilized for performing BNCT are composed of a mixture of neutrons and gamma rays. Although much of the dose delivered to the cancer cells comes from the high LET particles produced by the boron neutron capture rea…
View article: A national survey of medical staffs’ required capability and workload for accelerator-based boron neutron capture therapy
A national survey of medical staffs’ required capability and workload for accelerator-based boron neutron capture therapy Open
This study aimed to identify the required capabilities and workload of medical staff in accelerator-based boron neutron capture therapy (BNCT). From August to September 2022, a questionnaire related to the capabilities and workload in the …
View article: Preliminary outcomes of boron neutron capture therapy for head and neck cancers as a treatment covered by public health insurance system in Japan: Real‐world experiences over a 2‐year period
Preliminary outcomes of boron neutron capture therapy for head and neck cancers as a treatment covered by public health insurance system in Japan: Real‐world experiences over a 2‐year period Open
Purpose Since June 2020, boron neutron capture therapy (BNCT) has been a health care service covered by health insurance in Japan to treat locally advanced or recurrent unresectable head and neck cancers. Therefore, we aimed to assess the …
View article: Application of stoichiometric CT number calibration method for dose calculation of tissue heterogeneous volumes in boron neutron capture therapy
Application of stoichiometric CT number calibration method for dose calculation of tissue heterogeneous volumes in boron neutron capture therapy Open
Background Monte Carlo simulation code is commonly used for the dose calculation of boron neutron capture therapy. In the past, dose calculation was performed assuming a homogeneous mass density and elemental composition inside the tissue,…
View article: Safety of Boron Neutron Capture Therapy with Borofalan(10B) and Its Efficacy on Recurrent Head and Neck Cancer: Real-World Outcomes from Nationwide Post-Marketing Surveillance
Safety of Boron Neutron Capture Therapy with Borofalan(10B) and Its Efficacy on Recurrent Head and Neck Cancer: Real-World Outcomes from Nationwide Post-Marketing Surveillance Open
Background: This study was conducted to evaluate the real-world safety and efficacy of boron neutron capture therapy (BNCT) with borofalan(10B) in Japanese patients with locally advanced or locally recurrent head and neck cancer (LA/LR-HNC…
View article: Out‐of‐field dosimetry using a validated PHITS model and computational phantom in clinical BNCT
Out‐of‐field dosimetry using a validated PHITS model and computational phantom in clinical BNCT Open
Background The out‐of‐field radiation dose for boron neutron capture therapy (BNCT), which results from both neutrons and γ‐rays, has not been extensively evaluated. To safely perform BNCT, the neutron and γ‐ray distributions inside the tr…
View article: RADT-37. INTERIM RESULTS OF ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY, RANDOMIZED CONTROLLED TRIAL FOR RECURRENT AND REFRACTORY HIGH-GRADE MENINGIOMAS
RADT-37. INTERIM RESULTS OF ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY, RANDOMIZED CONTROLLED TRIAL FOR RECURRENT AND REFRACTORY HIGH-GRADE MENINGIOMAS Open
BACKGROUND High-grade meningiomas (HGMs) recurred after X-ray treatment showed 5.2 months as median progression free survival (mPFS) and only 24.6 months as median overall survival (mOS) from the literatures. Recently, we showed much more …
View article: Boron neutron capture therapy as a larynx-preserving treatment for locally recurrent laryngeal carcinoma after conventional radiation therapy: a preliminary report
Boron neutron capture therapy as a larynx-preserving treatment for locally recurrent laryngeal carcinoma after conventional radiation therapy: a preliminary report Open
Background: Preserving voice function is difficult in patients with local recurrence of laryngeal carcinoma after radiotherapy. The purpose of this study was to evaluate the efficacy and safety of boron neutron capture therapy (BNCT) for r…
View article: Real-World Results of Stereotactic Body Radiotherapy for 399 Medically Operable Patients with Stage I Histology-Proven Non-Small Cell Lung Cancer
Real-World Results of Stereotactic Body Radiotherapy for 399 Medically Operable Patients with Stage I Histology-Proven Non-Small Cell Lung Cancer Open
Surgery is the standard treatment for stage I non-small cell lung cancer (NSCLC); however, no clear randomized trial demonstrates its superiority to stereotactic body radiotherapy (SBRT) regarding survival. We aimed to retrospectively eval…
View article: A Japanese Multi-Institutional Phase II Study of Moderate Hypofractionated Intensity-Modulated Radiotherapy with Image-Guided Technique for Prostate Cancer
A Japanese Multi-Institutional Phase II Study of Moderate Hypofractionated Intensity-Modulated Radiotherapy with Image-Guided Technique for Prostate Cancer Open
Background Although moderate hypofractionated radiotherapy were one of standard regimens for localized prostate cancer, the efficacy of moderated hypofractionated regimens has not been well validated in Asian countries. The aim of this mul…
View article: KORTUC, a novel hydrogen peroxide‑based radiosensitizer for the enhancement of brachytherapy in patients with unresectable recurrent uterine cervical cancer
KORTUC, a novel hydrogen peroxide‑based radiosensitizer for the enhancement of brachytherapy in patients with unresectable recurrent uterine cervical cancer Open
Kochi Oxydol Radiation Therapy for Unresectable Carcinoma (KORTUC) is a novel radiosensitizer invented by Professor Ogawa at Kochi University (Japan) in 2006. The current study aimed to report the experience of the present authors with the…
View article: Reply
Reply Open
View article: Efficacy and Safety of Bladder Preservation Therapy in Combination with Atezolizumab and Radiation Therapy (BPT-ART) for Invasive Bladder Cancer: Interim Analysis from a Multicenter, Open-label, Prospective Phase 2 Trial
Efficacy and Safety of Bladder Preservation Therapy in Combination with Atezolizumab and Radiation Therapy (BPT-ART) for Invasive Bladder Cancer: Interim Analysis from a Multicenter, Open-label, Prospective Phase 2 Trial Open
Combination therapy with radiation therapy and atezolizumab provided high pCR rates and acceptable toxicity, indicating it could be a promising option for bladder preservation therapy.
View article: Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT
Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT Open
Background The goal of the study was to evaluate the diagnostic ability of 18 F-FBPA PET/CT for malignant tumors. Findings from 18 F-FBPA and 18 F-FDG PET/CT were compared with pathological diagnoses in patients with malignant tumors or be…
View article: ACT-4 EXPLORATORY PET EVALUATION OF BORON NEUTRON CAPTURE THERAPY FOR MALIGNANT GLIOMA REFRACTORY TO BEVACIZUMAB
ACT-4 EXPLORATORY PET EVALUATION OF BORON NEUTRON CAPTURE THERAPY FOR MALIGNANT GLIOMA REFRACTORY TO BEVACIZUMAB Open
Background We previously reported a phase II trial of accelerator-based boron neutron capture therapy (BNCT) for patients with malignant glioma, which showed a long median overall survival of 18.9 months. However, median progression-free s…
View article: RTID-06. A RANDOMIZED CONTROLLED TRIAL USING ACCELERATOR-BASED BNCT SYSTEM FOR REFRACTORY RECURRENT HIGH-GRADE MENINGIOMA
RTID-06. A RANDOMIZED CONTROLLED TRIAL USING ACCELERATOR-BASED BNCT SYSTEM FOR REFRACTORY RECURRENT HIGH-GRADE MENINGIOMA Open
BACKGROUNDS Recently, nuclear reactors have been replaced with accelerator-based neutron sources (ABNS) for boron neutron capture therapy (BNCT). High-grade meningiomas (HGM) are refractory, especially recurred after some radiotherapy. We …
View article: Final Analysis of Diagnostic Endoscopic Resection Followed by Selective Chemoradiotherapy for Stage I Esophageal Cancer: JCOG0508
Final Analysis of Diagnostic Endoscopic Resection Followed by Selective Chemoradiotherapy for Stage I Esophageal Cancer: JCOG0508 Open
View article: Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT
Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT Open
Background The goal of the study was to evaluate the diagnostic ability of 18 F-FBPA PET/CT for malignant tumors. Findings from 18 F-FBPA and 18 F-FDG PET/CT were compared with pathological diagnoses in patients with malignant tumors or be…
View article: Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region
Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region Open
View article: Comprehensive evaluation of dosimetric impact against position errors in accelerator‐based BNCT under different treatment parameter settings
Comprehensive evaluation of dosimetric impact against position errors in accelerator‐based BNCT under different treatment parameter settings Open
Background Patients who undergo accelerator‐based (AB) boron neutron capture therapy (BNCT) for head and neck cancer in the sitting position are generally uncomfortably immobilized, and patient motion during this treatment may be greater t…