Keiji Ueda
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View article: Potential for Core Fucose-Targeted Therapy Against HBV Infection of Human Normal Hepatocytes
Potential for Core Fucose-Targeted Therapy Against HBV Infection of Human Normal Hepatocytes Open
Core fucose is one of the most important glycans in HBV infection. In this study, we investigated whether Pholiota squarrosa lectin (PhoSL), a lectin that specifically binds to core fucose, exerts an inhibitory effect in an HBV infection m…
View article: Potential for Core Fucose-Targeted Therapy Against HBV Infection of Human Normal Hepatocytes
Potential for Core Fucose-Targeted Therapy Against HBV Infection of Human Normal Hepatocytes Open
Core fucose is one of the most important glycans in HBV infection. In this study, we investigated whether PhoSL, a lectin that specifically binds to core fucose, exerts an inhibitory effect in an HBV infection model of normal human hepatoc…
View article: Cell-intrinsic regulation of HBV RNAs by the nonsense-mediated mRNA decay pathway controls viral replication
Cell-intrinsic regulation of HBV RNAs by the nonsense-mediated mRNA decay pathway controls viral replication Open
Hepatitis B virus (HBV) is a causative agent for chronic liver hepatitis, which confers risk for liver cirrhosis and hepatocellular carcinoma. Among key viral transcripts, HBV pregenome RNA (pgRNA) is indispensable for viral replication, a…
View article: Analysis of the Functional Role of TIMM29 in the Hepatitis B Virus Life Cycle
Analysis of the Functional Role of TIMM29 in the Hepatitis B Virus Life Cycle Open
Hepatitis B virus (HBV) causes chronic hepatitis B, which can progress to liver cirrhosis and hepatocellular carcinoma. HBV has complex interactions with various cell organelles and proteins that ensure effective progeny virus production. …
View article: Method for Improving Fatigue Strength of Welded Joints by Using Split Boxing
Method for Improving Fatigue Strength of Welded Joints by Using Split Boxing Open
View article: Generation of Replication‐Competent Hepatitis B Virus Harboring Tagged Polymerase for Visualization and Quantification of the Infection
Generation of Replication‐Competent Hepatitis B Virus Harboring Tagged Polymerase for Visualization and Quantification of the Infection Open
Hepatitis B virus (HBV) infection is a serious global health problem causing acute and chronic hepatitis and related diseases. Approximately, 296 million patients have been chronically infected with the virus, leading to cirrhosis and hepa…
View article: Effect of oligosaccharyl transglycosylation on the cytotoxicity of cardiac glycoside proscillaridin A and its ability to inhibit hepatitis B virus infection
Effect of oligosaccharyl transglycosylation on the cytotoxicity of cardiac glycoside proscillaridin A and its ability to inhibit hepatitis B virus infection Open
Proscillaridin A, a cardiac glycoside, has been reported to inhibit taurocholic acid uptake via the sodium taurocholate cotransporter polypeptide, a functional receptor for hepatitis B virus (HBV), thereby directly or indirectly inhibiting…
View article: Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy
Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy Open
View article: Regulation of Hepatitis B Virus Replication by Modulating Endoplasmic Reticulum Stress (ER‐Stress)
Regulation of Hepatitis B Virus Replication by Modulating Endoplasmic Reticulum Stress (ER‐Stress) Open
Hepatitis B virus (HBV), resistant to several antiviral drugs due to viral genomic mutations, has been reported, which aggravates chronic infection and leads to hepatocellular carcinoma. Therefore, host cellular factors/signaling modulatio…
View article: The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro
The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro Open
Glycosylation of proteins and lipids in viruses and their host cells is important for viral infection and is a target for antiviral therapy. Hepatitis B virus (HBV) is a major pathogen that causes acute and chronic hepatitis; it cannot be …
View article: Impact of Borna Disease Virus Infection on the Transcriptome of Differentiated Neuronal Cells and Its Modulation by Antiviral Treatment
Impact of Borna Disease Virus Infection on the Transcriptome of Differentiated Neuronal Cells and Its Modulation by Antiviral Treatment Open
Borna disease virus (BoDV-1) is a highly neurotropic RNA virus that causes neurobehavioral disturbances such as abnormal social activities and memory impairment. Although impairments in the neural circuits caused by BoDV-1 infection induce…
View article: Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy
Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy Open
Chronic infection with Kaposi’s sarcoma-associated herpes virus (KSHV) in B lymphocytes causes primary effusion lymphoma (PEL), the most aggressive form of KSHV-related cancer, which is resistant to conventional chemotherapy. In this study…
View article: Identification of the Interaction between Minichromosome Maintenance Proteins and the Core Protein of Hepatitis B Virus
Identification of the Interaction between Minichromosome Maintenance Proteins and the Core Protein of Hepatitis B Virus Open
Chronic HBV infection is a major cause of cirrhosis and hepatocellular carcinoma. Finding host factors involved in the viral life cycle and elucidating their mechanisms is essential for developing innovative strategies for treating HBV. Th…
View article: Pholiota squarrosa lectin (PhoSL), a lectin binding to core-fucose specifically, inhibits HBV infection
Pholiota squarrosa lectin (PhoSL), a lectin binding to core-fucose specifically, inhibits HBV infection Open
Glycosylation in host cells and viruses is an important factor in viral infection and a target for anti-viral therapy. Hepatitis B virus (HBV) is a major pathogen causing acute /chronic hepatitis. To achieve the cure, new anti-HBV agents a…
View article: ATP5B Is an Essential Factor for Hepatitis B Virus Entry
ATP5B Is an Essential Factor for Hepatitis B Virus Entry Open
Elucidation of the factors responsible for hepatitis B virus (HBV) is extremely important in order to understand the viral life cycle and pathogenesis, and thereby explore potential anti-HBV drugs. The recent determination that sodium taur…
View article: Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant
Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant Open
Mutations in HBsAg, the surface antigen of the hepatitis B virus (HBV), might affect the serum HBV DNA level of HBV-infected patients, since the reverse transcriptase (RT) domain of HBV polymerase overlaps with the HBsAg-coding region. We …
View article: Challenges in the Application of Glyco-Technology to Hepatitis B Virus Therapy and Diagnosis
Challenges in the Application of Glyco-Technology to Hepatitis B Virus Therapy and Diagnosis Open
Hepatitis B virus (HBV) is a major pathogen that causes acute/chronic hepatitis. Continuous HBV infection can lead to the development of hepatocellular carcinoma (HCC). Although several different anti-HBV treatments are available for chron…
View article: Chronic Hepatitis B Treatment Strategies Using Polymerase Inhibitor-Based Combination Therapy
Chronic Hepatitis B Treatment Strategies Using Polymerase Inhibitor-Based Combination Therapy Open
Viral polymerase is an essential enzyme for the amplification of the viral genome and is one of the major targets of antiviral therapies. However, a serious concern to be solved in hepatitis B virus (HBV) infection is the difficulty of eli…
View article: Characterization of an active LINE-1 in the naked mole-rat genome
Characterization of an active LINE-1 in the naked mole-rat genome Open
View article: A Traditional Chinese Medicine, Maoto, Suppresses Hepatitis B Virus Production
A Traditional Chinese Medicine, Maoto, Suppresses Hepatitis B Virus Production Open
Worldwide, millions of people suffer from hepatitis B virus (HBV) infection, putting them at a high risk of death from liver cirrhosis and cancer. Although effective anti-HBV drugs have been developed, current drugs have some limitations, …
View article: Effects of activation of the LINE-1 antisense promoter on the growth of cultured cells
Effects of activation of the LINE-1 antisense promoter on the growth of cultured cells Open
View article: Suberoyl Bis-Hydroxamic Acid Reactivates Kaposi’s Sarcoma-Associated Herpesvirus through Histone Acetylation and Induces Apoptosis in Lymphoma Cells
Suberoyl Bis-Hydroxamic Acid Reactivates Kaposi’s Sarcoma-Associated Herpesvirus through Histone Acetylation and Induces Apoptosis in Lymphoma Cells Open
Kaposi’s sarcoma and primary effusion lymphoma cells are latently infected with Kaposi’s sarcoma-associated herpesvirus (KSHV), whereas KSHV replication is frequently observed in multicentric Castleman disease. Although KSHV replication ca…
View article: Interplay Between KSHV and the Host DNA Damage Response
Interplay Between KSHV and the Host DNA Damage Response Open
Interactions between viruses and cellular factors are essential for viral replication or host defense. The DNA damage response (DDR) orchestrates a molecular network of cellular mechanisms that integrates cell cycle regulation and DNA repa…
View article: TIMM29 interacts with hepatitis B virus preS1 to modulate the HBV life cycle
TIMM29 interacts with hepatitis B virus preS1 to modulate the HBV life cycle Open
Hepatitis B virus (HBV), a major global health problem, can cause chronic hepatitis, liver cirrhosis, and hepatocellular carcinomas in chronically infected patients. However, before HBV infection can be adequately controlled, many mysterie…
View article: Suberoyl bis-hydroxamic acid reactivates Kaposi’s sarcoma-associated herpesvirus through histone acetylation and induces apoptosis in lymphoma cells
Suberoyl bis-hydroxamic acid reactivates Kaposi’s sarcoma-associated herpesvirus through histone acetylation and induces apoptosis in lymphoma cells Open
Kaposi’s sarcoma-associated herpesvirus (KSHV) is an etiologic agent of Kaposi’s sarcoma as well as primary effusion lymphoma (PEL), an aggressive B-cell neoplasm which mostly arises in immunocompromised individuals. At present, there is n…
View article: Establishment of a system for finding inhibitors of ε RNA binding with the HBV polymerase
Establishment of a system for finding inhibitors of ε RNA binding with the HBV polymerase Open
Although several nucleo(s)tide analogs are available for treatment of HBV infection, long‐term treatment with these drugs can lead to the emergence of drug‐resistant viruses. Recent HIV‐1 studies suggest that combination therapies using nu…
View article: Infection-Associated Cancers
Infection-Associated Cancers Open
View article: Complete Genome Sequence of a Precore-Defective Hepatitis B Virus Genotype D2 Strain Isolated in Bangladesh
Complete Genome Sequence of a Precore-Defective Hepatitis B Virus Genotype D2 Strain Isolated in Bangladesh Open
Hepatitis B virus (HBV) genomic mutations affect viral replication, disease progression, and diagnostic and vaccination efficiency. There is limited information regarding characterization and mutational analysis of HBV isolated in Banglade…
View article: Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins
Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins Open
Around 350 million people are living with hepatitis B virus (HBV), which can lead to death due to liver cirrhosis and hepatocellular carcinoma (HCC). Various antiviral drugs/nucleot(s)ide analogues are currently used to reduce or arrest th…
View article: PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh
PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh Open
Mutations in the hepatitis B virus (HBV) genome can potentially lead to vaccination failure, diagnostic escape, and disease progression. However, there are no reports on viral gene expression and large hepatitis B surface antigen (HBsAg) a…