Explanipedia

Disproportionality Analysis of Gastrointestinal Adverse Events Associated With Trastuzumab Deruxtecan Using the Japanese Adverse Drug Event Report database Open

Yuko Kanbayashi, Rogério Yukio Morioka, Koichi Takayama, Keiko Hosohata · 2025

Gastrointestinal adverse events associated with T-DXd can arise early or later in treatment and may lead to serious or fatal outcomes. These findings underscore the importance of continuous post-marketing surveillance and proactive clinica…

Association of Clopidogrel with Interstitial Lung Disease: Gaining Insight Through the Japanese Pharmacovigilance Database Open

Mariko Kozaru, Hiroko Kambara, Akari Higuchi, Tatsuki Kagatsume, Keiko Hosohata · 2024

This analysis of the national pharmacovigilance database highlights distinct AE profiles for clopidogrel and prasugrel. Unexpected AEs associated with clopidogrel were identified, providing valuable insights for clinical monitoring and pat…

Association Between COVID-19 and Diabetes Management Indices in Japanese Type 2 Diabetes Mellitus Patients: A Single-Center, Retrospective Study Open

Kazuhiro Furumachi, Tatsuki Kagatsume, Akari Higuchi, Mariko Kozaru, Etsuko Kumagai , et al. · 2024

The results suggest an association between high HbA1c levels and COVID-19 infection in patients with type 2 diabetes mellitus. Appropriate management of diabetes mellitus, focusing on HbA1c levels, may help prevent COVID-19 infection and s…

Risk Factors for COVID-19 Infection in Adult Patients: A Retrospective Observational Study in Japan Open

Akie Yoshida, Kazuhiro Furumachi, Etsuko Kumagai, Keiko Hosohata · 2024

BUN and Scr are potential risk factors for infection of COVID-19 in Japanese patients, particularly in men. Our results suggest that renal parameters might be important in Japanese male patients for the early detection of COVID-19 infectio…

A Pharmacovigilance Study of Drug-Induced Glaucoma Utilizing the Japanese Adverse Event Reporting System Open

Mariko Kozaru, Tatsuya Iida, Keiko Hosohata · 2023

A national pharmacovigilance database enabled us to identify the drugs that frequently induce glaucoma. The likelihood of the reporting of glaucoma varied among the drugs, which should be used carefully in clinical practice to avoid it.

Zinc Acetate Hydrate Supplementation versus Polaprezinc Supplementation for Improving Hypozincemia in Hemodialysis Patients: A Randomized Clinical Trial Open

Etsuko Kumagai, Kazuhiro Furumachi, Akihiro Kurihara, Ken Hosokawa, Keiko Hosohata , et al. · 2023

Zinc supplementation may ameliorate zinc deficiency in maintenance hemodialysis patients; however, no standard protocol has been established. This study aimed to investigate the effects of zinc acetate hydrate (ZAH) and polaprezinc (PPZ) a…

Impact of medication adherence on renal denervation trials in resistant hypertensive patients Open

Keiko Hosohata · 2023

Current Status of Adverse Event Profile of Cyclosporine in Kidney, Stem Cell, and Heart Transplantations Using the Japanese Pharmacovigilance Database Open

Iku Niinomi, Saki Oyama, Ayaka Inada, Tomohito Wakabayashi, Tatsuya Iida , et al. · 2022

It was suggested that there is a diversity in the strength of the association between cyclosporine and adverse events in the kidney, stem cell, and heart transplantation. Our results may provide useful information for treatment with cyclos…

Biologic Disease-Modifying and Other Anti-Rheumatic Drugs Use in Patients with Moderate-to-Severe Juvenile Idiopathic Arthritis Based on a Japanese Nationwide Claims Database Open

Takeo Hata, Atsushi Hirata, Ryosuke Ota, Keiko Hosohata, Masami Nishihara , et al. · 2022

Although the introduction of bDMARDs has markedly improved the efficacy of JIA therapy, there are still many short- and long-term safety issues to be examined, including the risk of infection and potential risk of associated malignancy. Fu…

Ferroptosis: A Potential Therapeutic Target in Acute Kidney Injury Open

Keiko Hosohata, Tanisorn Harnsirikarn, Susama Chokesuwattanaskul · 2022

Ferroptosis is a recently recognized form of nonapoptotic cell death that is triggered by reactive oxidative species (ROS) due to iron overload, lipid peroxidation accumulation, or the inhibition of phospholipid hydroperoxidase glutathione…

Design, synthesis, and evaluation of new vanin-1 inhibitors based on RR6 Open

Hiroki Yoneyama, Keiko Hosohata, Denan Jin, Iroha Yoshida, Miyui Toyoda , et al. · 2022

Evaluation of Medication Instruction Sheets for Patients Undergoing R-CHOP Therapy in Non-Hodgkin’s Lymphoma Open

Mayako Uchida, Rika Kawai, RIE HISAMITSU, SAYAKA MAI, Shigeru Ishida , et al. · 2022

The present MIS could be useful for monitoring ADRs in patients with cancer undergoing R-CHOP therapy.

Synthesis and evaluation of activities of new pantetheine derivatives Open

Keiko Hosohata, Hiroki Yoneyama, Denan Jin, Yoshihide Usami, Shinji Takai · 2022

Background: Acute kidney injury (AKI) is associated with incomplete recovery after the onset of the disease. However, there is no fundamental treatment for this disease. Previously, we identified vanin-1, which appears on the cell surface …

Evaluation of urinary biomarkers in ischemia/reperfusion-induced renal injury Open

Keiko Hosohata, Denan Jin, Shinji Takai · 2022

Acute kidney injury (AKI) has been linked to an increased risk of developing chronic kidney disease (CKD). In the pathophysiology of AKI, oxidative stress plays a pivotal role. Previously, we reported that vanin-1, which is involved in oxi…

Glaucocalyxin A Ameliorates Hypoxia/Reoxygenation-Induced Injury in Human Renal Proximal Tubular Epithelial Cell Line HK-2 Cells Open

Keiko Hosohata, Denan Jin, Shinji Takai · 2021

Ischemia-reperfusion injury is one of the major causes of acute kidney injury (AKI), which is increasingly prevalent in clinical settings. Glaucocalxin A (GLA), a biologically ent-kauranoid diterpenoid, has various pharmacological effects …

In Vivo and In Vitro Evaluation of Urinary Biomarkers in Ischemia/Reperfusion-Induced Kidney Injury Open

Keiko Hosohata, Denan Jin, Shinji Takai · 2021

Oxidative stress plays an important role in the pathophysiology of acute kidney injury (AKI). Previously, we reported that vanin-1, which is involved in oxidative stress, is associated with renal tubular injury. This study was aimed to det…

Association of urinary vanin‐1 with kidney function decline in hypertensive patients Open

Keiko Hosohata, Hiroyuki Matsuoka, Etsuko Kumagai · 2021

Previously, the authors reported the utility of urinary vanin‐1 as an early biomarker of kidney injury in spontaneously hypertensive rats and in humans. However, little is known about whether urinary vanin‐1 can be used to predict the clin…

Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study Open

Tomohito Wakabayashi, Keiko Hosohata, Saki Oyama, Ayaka Inada, Iku Niinomi , et al. · 2021

Objectives Proton pump inhibitors (PPIs) are widely used for acid suppression therapy. Recently, PPI use was reported to be associated with chronic kidney disease (CKD); however, whether a low dose of PPIs is associated with CKD remains un…

Drug-induced Neuropsychiatric Adverse Events Using Post-MarketingSurveillance Open

Keiko Hosohata, Tomohito Wakabayashi, Takahiro Nakatsuji, Hiroko Kambara, Iku Niinomi , et al. · 2021

Background: Several studies reported that abnormal behavior was noted in pediatric patients receiving several drugs, including neuraminidase inhibitors (NIs). However, the information on drugs associated with abnormal behavior in a real-wo…

Pharmacovigilance Evaluation of Bendamustine-related Skin Disorders using the Japanese Adverse Drug Event Report Database Open

Mayako Uchida, Takehiro Kawashiri, Nami Maegawa, Aoi Takano, Keiko Hosohata , et al. · 2021

Purpose: Bendamustine is used in hematologic malignancies such as non-Hodgkin lymphoma, chronic lymphocytic leukemia, and multiple myeloma. This study evaluated the association of bendamustine-related skin disorders using the Japanese Adve…

Acute Kidney Injury Impacts on Hypokalemia Associated with Yokukansan Preparation: A Retrospective Observational Study Open

Toshinori Hirai, Ryosuke Yamaga, Motoki Kei, Keiko Hosohata, Toshimasa Itoh · 2020

The time course of acute kidney injury and hypokalemia remains unelucidated. We investigated whether altered renal function impacts hypokalemia and clinical predictors for acute kidney injury in patients who used Yokukansan preparation. We…

Geriatric Patients Are at a High Risk of Hypokalemia Associated with Yokukansan Preparation: A Retrospective Cohort Study Open

Toshinori Hirai, Ryosuke Yamaga, Motoki Kei, Keiko Hosohata, Toshimasa Itoh · 2020

Although hypokalemia is an adverse effect of Yokukansan preparation, especially in geriatric patients, its association with age is unclear. We investigated whether age is a risk factor for hypokalemia. This single-center retrospective coho…

Risk Factors for Skin Toxicities Associated with Bendamustine-Based Chemotherapy in Patients with Non-Hodgkin Lymphoma Open

Mayako Uchida, Yasuhiro Mori, Kenta Akiba, Moena Miyasaka, Tatsuya Hirano , et al. · 2020

Bendamustine plays an especially important role as a treatment for non-Hodgkin lymphoma (NHL). However, patients administered bendamustine alone or in combination with rituximab (BR) may experience drug-associated skin toxicities that can …

Comparison of Adverse Event Profiles of Tumor Necrosis Factor-Alfa Inhibitors: Analysis of a Spontaneous Reporting Database Open

Tomohito Wakabayashi, Keiko Hosohata, Sakiko Oyama, Ayaka Inada, Sayaka Ueno , et al. · 2020

Tomohito Wakabayashi, Keiko Hosohata, Saki Oyama, Ayaka Inada, Sayaka Ueno, Hiroko Kambara, Tatsuya Iida, Takahiro Nakatsuji, Mayako Uchida, Kazunori Iwanaga Education and Research Center for Clinical Pharmacy, Osaka University of Pharmace…

Urinary vanin‐1 associated with chronic kidney disease in hypertensive patients: A pilot study Open

Keiko Hosohata, Hiroyuki Matsuoka, Kazunori Iwanaga, Etsuko Kumagai · 2020

Hypertension and chronic kidney disease (CKD) are serious interrelated public health problems. Despite the monitoring and control of high blood pressure, symptoms of CKD are not usually apparent in its early stages. Previously, we reported…

Comparison of Adverse Event Profiles of Tumor Necrosis Factor-Alfa Inhibitors: Analysis of a Spontaneous Reporting Database Open

Tomohito Wakabayashi, Keiko Hosohata, Saki Oyama, Ayaka Inada, Sayaka Ueno , et al. · 2020

The strength of the associations of TNF-alfa inhibitors with adverse events is variable, and further studies are required to evaluate the identified signals.

Roles Played by Biomarkers of Kidney Injury in Patients with Upper Urinary Tract Obstruction Open

Satoshi Washino, Keiko Hosohata, Tomoaki Miyagawa · 2020

Partial or complete obstruction of the urinary tract is a common and challenging urological condition caused by a variety of conditions, including ureteral calculi, ureteral pelvic junction obstruction, ureteral stricture, and malignant ur…

Range of plasma brain natriuretic peptide (BNP) levels in hemodialysis patients at a high risk of 1-year mortality and their relationship with the nutritional status: a retrospective cohort study in one institute Open

Etsuko Kumagai, Keiko Hosohata, Kazuhiro Furumachi, Shinji Takai · 2020

Background Brain natriuretic peptide (BNP) levels are used as a marker of heart failure, which is the leading cause of morbidity and mortality in dialysis patients. BNP levels increase as renal function declines. The range of BNP levels as…

Risk Factors for Febrile Neutropenia Induced by Docetaxel Chemotherapy in Patients with Non-small Cell Lung Cancer Open

Mayako Uchida, Yuki Yamaguchi, Syuhei Hosomi, Hiroaki Ikesue, Yasuhiro Mori , et al. · 2020

We retrospectively obtained data of patient background and pretreatment characteristics from medical records and identified the predictive factors of febrile neutropenia (FN) in patients with non-small cell lung cancer (NSCLC) treated with…

Improvement of Blood Pressure Control by Adherence Check in Patients With Apparent Treatment-Resistant Hypertension: A Case Series Open

Keiko Hosohata, Ayaka Inada, Saki Oyama, Takashi Doi, Iku Niinomi , et al. · 2020

Adherence to medications is an important challenge while treating chronic disease such as resistant hypertension, which is defined as uncontrolled blood pressure (BP) despite treatment with more than 3 antihypertensive drugs to achieve tar…

Keiko Hosohata YOU? Author Swipe