Keiko Miura
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View article: Validation of the <scp>ABC</scp> Method for Gastric Cancer Risk Stratification Across <i>Helicobacter pylori</i> Infections With Diverse CagA Status and Subtypes in Brazil
Validation of the <span>ABC</span> Method for Gastric Cancer Risk Stratification Across <i>Helicobacter pylori</i> Infections With Diverse CagA Status and Subtypes in Brazil Open
Background Gastric cancer survival rates vary across countries due to differences in access to early diagnostic testing and healthcare quality. Endoscopy, though accurate, is not feasible for mass screening. The ABC method, which combines …
View article: The potential value of thallium‐201 scintigraphy in the diagnosis of squamous cell carcinoma arising from extensive pyoderma
The potential value of thallium‐201 scintigraphy in the diagnosis of squamous cell carcinoma arising from extensive pyoderma Open
Squamous cell carcinoma (SCC) arises from a variety of premalignant conditions, including pyoderma. However, an accurate diagnosis of SCC is sometimes challenging due to indistinguishable inflammatory lesions. Here, we present a case of SC…
View article: Immunohistochemical Differentiation between Western and East Asian Types of CagA-Positive Helicobacter pylori in Gastric Biopsy Samples
Immunohistochemical Differentiation between Western and East Asian Types of CagA-Positive Helicobacter pylori in Gastric Biopsy Samples Open
Background. Cag A-positive Helicobacter pylori isolated from human gastric mucosa is categorized as a Western or East Asian allele-type based on whether the cagA gene encodes an EPIYA-C or EPIYA-D motif. We aimed to differentiate between t…
View article: Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions
Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions Open
Background The status of cutaneous epithelioid angiomatous nodule (CEAN) as a distinct entity remains controversial. This study investigated the relationship between CEAN and epithelioid hemangioma/angiolymphoid hyperplasia with eosinophil…
View article: Propionibacterium acnes-Derived Circulating Immune Complexes in Sarcoidosis Patients
Propionibacterium acnes-Derived Circulating Immune Complexes in Sarcoidosis Patients Open
Propionibacterium acnes is a potential etiologic agent of sarcoidosis and a dysregulated immune response to the commensal bacterium is suspected to cause granuloma formation. P. acnes-derived insoluble immune complexes were recently demons…
View article: Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi
Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi Open
Early differential diagnosis between malignant and benign tumors and their underlying intrinsic differences are the most critical issues for life-threatening cancers. To study whether human acral melanomas, deadly cancers that occur on non…
View article: Supraclavicular Scrofuloderma: A Diagnostic Challenge without Apparent Clinical Manifestations of Tuberculosis
Supraclavicular Scrofuloderma: A Diagnostic Challenge without Apparent Clinical Manifestations of Tuberculosis Open
Scrofuloderma is one of the cutaneous manifestations of tuberculosis and usually occurs when underlying tuberculosis such as lymphadenitis directly involves the skin. However, the diagnosis of scrofuloderma without other apparent clinical …
View article: Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma
Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma Open
Objectives The diagnostic utility of En1 in the histopathologic differentiation of eccrine porocarcinoma (EPC) from invasive squamous cell carcinoma (SCC) was investigated. Methods Expression of En1 and CK19 in 16 cases of EPC was immunohi…
View article: Sebaceous carcinoma in the inguinal region: Two case reports
Sebaceous carcinoma in the inguinal region: Two case reports Open
脂腺癌は脂腺への分化をもつ上皮性悪性腫瘍で，高齢者の頭頚部に好発することから，紫外線暴露との関係が示唆されている．今回我々は鼡径部に生じた脂腺癌を2例経験したので病理学的特徴の考察を踏まえて報告する． 症例1：50歳，男性．初診の1年前から右鼡径部に皮疹が出現し，増大した．約60×40 mm大の紅色腫瘤を摘出した．症例2：77歳，女性．20年前より左鼡径部に皮疹が徐々に増大した．27×15 mm大の潰瘍を伴う紅褐色結節を切除し，病理組織学的検討を行った．自験例2例とも，脂腺…
View article: Squamous cell carcinoma and verrucous carcinoma arising from chronic cutaneous lupus erythematosus : A case report
Squamous cell carcinoma and verrucous carcinoma arising from chronic cutaneous lupus erythematosus : A case report Open
56歳，男性。15年前に円板状エリテマトーデスと診断されたが途中通院を自己中断し，その間外用・内服治療なく経過した。右手背部のdiscold lupus erythematosus（DLE）皮疹部を掻破し自壊，増殖性の結節が出現した。受診時に右膝の紅色局面を同時に指摘された。右手背の腫瘤と右膝の角化性結節を生検したところ，前者は有棘細胞癌，後者は疣贅様変化を認めた。右手背腫瘤を全切除し左前外側大腿皮弁にて再建した。右手背全切除標本にても組織学的に表皮索が舌状に増大し癌真珠を…
View article: Cancer gland rupture as a potential risk factor for lymph node metastasis in early colorectal adenocarcinoma with deep submucosal invasion
Cancer gland rupture as a potential risk factor for lymph node metastasis in early colorectal adenocarcinoma with deep submucosal invasion Open
Aims Lymph node metastasis (LNM) has not been found in more than 85% of patients with early invasive colorectal adenocarcinoma (T1‐CRAC) who undergo surgery after therapeutic endoscopy due to the risk for LNM. Better histological risk asse…
View article: Intensity Modulated Radiation Therapy for Syringomatous Carcinoma of the Face: A Case Report
Intensity Modulated Radiation Therapy for Syringomatous Carcinoma of the Face: A Case Report Open
Sweat gland carcinomas are extremely rare tumors. The age-adjusted incidence rate of cutaneous appendageal carcinomas, including sweat gland carcinomas, is 5.1 per 1 million person-years.1 The main treatment method is wide local excision a…
View article: Poromas with large lumens histopathologically mimicking syringocystadenoma papilliferum: Report of three cases
Poromas with large lumens histopathologically mimicking syringocystadenoma papilliferum: Report of three cases Open
We report on three patients exhibiting tumours with exophytic pedunculated structures with eroded surfaces. All cases showed the basic histopathological features of poroma accompanied by large, invaginated ductal structures lined by multip…
View article: Methotrexate-Associated Lymphoproliferative Disorder: Dermoscopic Features
Methotrexate-Associated Lymphoproliferative Disorder: Dermoscopic Features Open
Methotrexate-related lymphoproliferative disorder (MTX-LPD) is a rare disorder caused by long-term MTX therapy for autoimmune diseases. There has been no report of the dermoscopic features of MTX-LPD to date. A 64-year-old female presented…
View article: A case of cystic basal cell carcinoma of the vulva
A case of cystic basal cell carcinoma of the vulva Open
32歳，女性。2年前に自覚し，妊娠中に増大した右大陰唇の淡紅色結節。3×2cm大で弾性軟。ダーモスコピーで部分的に青白色調を呈し，多発性青灰色小球がみられた。樹枝状血管が目立つ。病理所見：結節の大部分が巨大な囊腫で形成されている。囊腫壁の細胞は，毛芽細胞様で，内部に壊死した腫瘍細胞とムチンの存在が推測された。周囲に小型の充実性胞巣あり，柵状配列を伴う。周囲には裂隙とコロイド鉄，アルシアンブルー陽性のムチン沈着あり。免疫染色でBerEP4とBcl－2が陽性でありCK20陽性細…
View article: Bazex Syndrome in Lung Squamous Cell Carcinoma: High Expression of Epidermal Growth Factor Receptor in Lesional Keratinocytes with Th2 Immune Shift
Bazex Syndrome in Lung Squamous Cell Carcinoma: High Expression of Epidermal Growth Factor Receptor in Lesional Keratinocytes with Th2 Immune Shift Open
An 82-year-old Japanese man was referred for detailed examination of hyperkeratotic erythematous plaques on his palms and soles for 6 months. Two weeks before his first visit, he had undergone lung lobectomy for right lung squamous cell ca…
View article: Solitary eccrine syringofibroadenoma: a case report showing papillary tubular adenoma-like features
Solitary eccrine syringofibroadenoma: a case report showing papillary tubular adenoma-like features Open
We herein describe a case showing eccrine syringofibroadenoma occurred on the dorsum of the right foot of a 46-year-old Japanese female. Histopathologic examination revealed anastomosing cords and strands of cuboidal epithelial cells exten…
View article: Four Different Tumors Arising in a Nevus Sebaceous
Four Different Tumors Arising in a Nevus Sebaceous Open
Nevus sebaceous is known by its association with one or more secondary tumors, but more than three multiple tumors arising from a nevus sebaceous is extremely rare. A 67-year-old female presented with a light brown plaque on the back of he…
View article: Increased Infiltration of CD8<sup>+</sup>T Cells by Dacarbazine in a Patient with Mucosal Penile Melanoma Refractory to Nivolumab
Increased Infiltration of CD8<sup>+</sup>T Cells by Dacarbazine in a Patient with Mucosal Penile Melanoma Refractory to Nivolumab Open
Primary penile melanomas are rare tumors that represent less than 0.1% of all melanomas. We report a case of a 60-year-old Japanese male with a mucosal penile melanoma and describe an increased CD8+ T cell infiltration in brain after dacar…