Keiko Omori
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View article: Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation
Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation Open
Although islet transplantation is effective in reducing severe hypoglycemia events and controlling blood glucose in patients with type 1 diabetes, maintaining islet graft function long-term is a significant challenge. Islets from multiple …
View article: Impact of Tacrolimus, Sirolimus, Age, and Body Mass Index on the Occurrence of Skin Cancer and Islet Dysfunction After Transplantation
Impact of Tacrolimus, Sirolimus, Age, and Body Mass Index on the Occurrence of Skin Cancer and Islet Dysfunction After Transplantation Open
Herein, we characterized the percentage of tacrolimus to the combined sirolimus and tacrolimus trough levels (tacrolimus %) observed during islet transplant-associated immune suppression therapy with post-transplant skin cancer. Although t…
View article: Biological hypoxia in pre-transplant human pancreatic islets induces transplant failure in diabetic mice
Biological hypoxia in pre-transplant human pancreatic islets induces transplant failure in diabetic mice Open
Evaluating the quality of isolated human islets before transplantation is crucial for predicting the success in treating Type 1 diabetes. The current gold standard involves time-intensive in vivo transplantation into diabetic immunodeficie…
View article: Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets
Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets Open
Pancreatic islet transplantation is one of the clinical options for certain types of diabetes. However, difficulty in maintaining islets prior to transplantation limits the clinical expansion of islet transplantations. Our study introduces…
View article: Risk factors for postoperative complications in patients with Parkinson disease: A single center retrospective cohort study
Risk factors for postoperative complications in patients with Parkinson disease: A single center retrospective cohort study Open
Surgical treatment for patients with Parkinson disease (PD) under general anesthesia has become frequent. PD is a significant predictor of postoperative complications. However, the factors that predict complications in patients with PD rem…
View article: Microwell culture platform maintains viability and mass of human pancreatic islets
Microwell culture platform maintains viability and mass of human pancreatic islets Open
Background Transplantation of the human pancreatic islets is a promising approach for specific types of diabetes to improve glycemic control. Although effective, there are several issues that limit the clinical expansion of this treatment,…
View article: Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival
Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival Open
Hypothermic (cold) preservation is a limiting factor for successful cell and tissue transplantation where cell swelling (edema) usually develops, impairing cell function. University of Wisconsin (UW) solution, a standard cold preservation …
View article: Chronic marijuana usage by human pancreas donors is associated with impaired islet function
Chronic marijuana usage by human pancreas donors is associated with impaired islet function Open
We investigated the effect of chronic marijuana use, defined as 4 times weekly for more than 3 years, on human pancreatic islets. Pancreata from deceased donors who chronically used marijuana were compared to those from age, sex and ethnic…
View article: A Multiparametric Assessment of Human Islets Predicts Transplant Outcomes in Diabetic Mice
A Multiparametric Assessment of Human Islets Predicts Transplant Outcomes in Diabetic Mice Open
Prior to transplantation into individuals with type 1 diabetes, in vitro assays are used to evaluate the quality, function and survival of isolated human islets. In addition to the assessments of these parameters in islet, they can be eval…
View article: Inflammatory biomarkers in the blood and pancreatic tissue of organ donors that predict human islet isolation success and function
Inflammatory biomarkers in the blood and pancreatic tissue of organ donors that predict human islet isolation success and function Open
The pancreas of brain-dead donors is the primary source of islets for transplantation. However, brain death mediates systemic inflammation, which may affect the quantity and quality of isolated islets. Our aim was to identify inflammatory …
View article: Semi-Automated Assessment of Human Islet Viability Predicts Transplantation Outcomes in a Diabetic Mouse Model
Semi-Automated Assessment of Human Islet Viability Predicts Transplantation Outcomes in a Diabetic Mouse Model Open
In clinical and experimental human pancreatic islet transplantations, establishing pretransplant assessments that accurately predict transplantation outcomes is crucial. Conventional in vitro viability assessment that relies on manual coun…
View article: Optimal Time to Ship Human Islets Post Tissue Culture to Maximize Islet Recovery
Optimal Time to Ship Human Islets Post Tissue Culture to Maximize Islet Recovery Open
Access to functional high-quality pancreatic human islets is critical to advance diabetes research. The Integrated Islet Distribution Program (IIDP), a major source for human islet distribution for over 15 years, conducted a study to evalu…
View article: Evaluation of collagenase gold plus BP protease in isolating islets from human pancreata
Evaluation of collagenase gold plus BP protease in isolating islets from human pancreata Open
Selection of enzymes for optimal pancreas digestion is essential for successful human islet isolations. The aim of this study was to evaluate the efficacy and outcome of using Collagenase Gold plus BP protease (VitaCyte) (n = 8) by compari…
View article: Posttransplant oxygen inhalation improves the outcome of subcutaneous islet transplantation: A promising clinical alternative to the conventional intrahepatic site
Posttransplant oxygen inhalation improves the outcome of subcutaneous islet transplantation: A promising clinical alternative to the conventional intrahepatic site Open
Subcutaneous tissue is a promising site for islet transplantation, due to its large area and accessibility, which allows minimally invasive procedures for transplantation, graft monitoring, and removal of malignancies as needed. However, r…
View article: Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming
Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming Open
Long-term pancreatic cold ischemia contributes to decreased islet number and viability after isolation and culture, leading to poor islet transplantation outcome in patients with type 1 diabetes. In this study, we examined mechanisms of pa…
View article: Determination of Islet Viability Using a Zinc-Specific Fluorescent Dye and a Semiautomated Assessment Method
Determination of Islet Viability Using a Zinc-Specific Fluorescent Dye and a Semiautomated Assessment Method Open
Islet transplantation is an effective therapy that allows the achievement of insulin independence in patients with type 1 diabetes (T1D). To ensure successful transplantation, islet viability and function are of great importance. Viability…
View article: Prophylactically Decontaminating Human Islet Product for Safe Clinical Application
Prophylactically Decontaminating Human Islet Product for Safe Clinical Application Open
This study demonstrated that the refined method reduces the rate of contamination of the islet final product and is safe for clinical application. Moreover, it may be used as a standard method during human islet manufacturing facilitating …