Keiko Taguchi
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View article: Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study
Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study Open
Essential trace elements, such as iron (Fe) and selenium (Se), play physiological roles in our body, whereas environmental toxic metals, such as arsenic (As), cadmium (Cd), and mercury (Hg), are known to be associated with various disease …
View article: Diverse Cre recombinase expression pattern in Albumin-Cre driver rats
Diverse Cre recombinase expression pattern in Albumin-Cre driver rats Open
Rats (Rattus norvegicus) have been widely utilized as model animals due to their physiological characteristics, making them suitable for surgical and long-term studies. They have played a crucial role in biomedical research, complementing …
View article: Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma
Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma Open
In esophageal squamous cell carcinoma, genetic activation of NRF2 increases resistance to chemotherapy and radiotherapy, which results in a significantly worse prognosis for patients. Therefore NRF2-activated cancers create an urgent clini…
View article: Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion
Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion Open
Bcl2-associated athanogene-1 protein (Bag1) acts as a co-chaperone of heat shock protein 70 and heat shock cognate 70 and regulates multiple cellular processes, including cell proliferation, apoptosis, environmental stress response, and dr…
View article: Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals
Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals Open
Whole blood transcriptome analysis is a valuable approachin medical research, primarily due to the ease of sample collection and the richness of the information obtained. Since the expression profile of individual genes in the analysis is …
View article: Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes
Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes Open
Background and Aims: Cancer cells reprogram their metabolic pathways to support bioenergetic and biosynthetic needs and to maintain their redox balance. In several human tumors, the Keap1-Nrf2 system controls proliferation and metabolic re…
View article: A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells Open
While it is well established that the KEAP1-NRF2 pathway regulates the main inducible cellular response to oxidative stress, this cytoprotective function of NRF2 could become deleterious to the host if it confers survival onto irreparably …
View article: The KEAP1-NRF2 System and Esophageal Cancer
The KEAP1-NRF2 System and Esophageal Cancer Open
NRF2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that regulates the expression of many cytoprotective genes. NRF2 activation is mainly regulated by KEAP1 (kelch-like ECH-associated protein 1) through ubiquitinat…
View article: Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology
Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology Open
Long-read sequencing technology enable better characterization of structural variants (SVs). To adapt the technology to population-scale analyses, one critical issue is to obtain sufficient amount of high-molecular-weight genomic DNA. Here…
View article: JSV1 VCF
JSV1 VCF Open
JSV1, a structural variation panel utilizing long-read sequencing technology of 333 individuals composing 111 trios.
View article: JSV1-paper-dataset
JSV1-paper-dataset Open
Datasets and software for "Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technologyConstruction of a trio-based structural variation panel utilizing activated T lymphocyt…
View article: JSV1-paper-dataset
JSV1-paper-dataset Open
Datasets and software for "Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technologyConstruction of a trio-based structural variation panel utilizing activated T lymphocyt…
View article: JSV1 VCF
JSV1 VCF Open
JSV1, a structural variation panel utilizing long-read sequencing technology of 333 individuals composing 111 trios.
View article: JSV1-paper-dataset
JSV1-paper-dataset Open
Datasets and software for "Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technologyConstruction of a trio-based structural variation panel utilizing activated T lymphocyt…
View article: JSV1-paper-dataset
JSV1-paper-dataset Open
Datasets and software for "Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technologyConstruction of a trio-based structural variation panel utilizing activated T lymphocyt…
View article: The <i>β</i>-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation <i>In Vivo</i>
The <i>β</i>-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation <i>In Vivo</i> Open
Nrf2 activates cytoprotective gene expression, and Nrf2 activity is regulated through at least two protein degradation pathways: the Keap1-mediated and β-TrCP-mediated pathways. To address the relative contributions of these pathways, we g…
View article: AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis
AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis Open
Skin is constantly exposed to environmental insults, including toxic chemicals and oxidative stress. These insults often provoke perturbation of epidermal homeostasis and lead to characteristic skin diseases. AHR (aryl hydrocarbon receptor…
View article: Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition
Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition Open
Pancreatic cancer remains intractable owing to the lack of effective therapy for unresectable cases. Activating mutations of K-ras are frequently found in pancreatic cancers, but these have not yet been targeted by cancer therapies. The Ke…
View article: The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment
The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment Open
The Kelch-like ECH-associated protein 1 (KEAP1)—Nuclear factor erythroid-derived 2-like 2 (encoded by the Nfe2l2 gene; NRF2) system attracts extensive interest from scientists in basic and clinical cancer research fields, as NRF2 exhibits …
View article: Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium
Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium Open
Nrf2 is essential for cytoprotection against carcinogens, and through systemic Nrf2 knockout mice, Nrf2-deficient cells were shown to be susceptible to chemical carcinogens and prone to developing cancers. However, the oncogenic potential …