Keisuke Jimbo
YOU?
Author Swipe
View article: Feasibility and Safety of Small Bowel Capsule Endoscopy in Very Early-Onset Inflammatory Bowel Disease: A Multi-Institutional Study
Feasibility and Safety of Small Bowel Capsule Endoscopy in Very Early-Onset Inflammatory Bowel Disease: A Multi-Institutional Study Open
Background Small bowel capsule endoscopy is a valuable modality for evaluating small intestinal lesions in children with inflammatory bowel disease. However, its application for very early-onset inflammatory bowel disease remains insuffici…
View article: Expert consensus on diagnostic guidelines for pediatric inflammatory bowel disease in Japan
Expert consensus on diagnostic guidelines for pediatric inflammatory bowel disease in Japan Open
Background Inflammatory bowel disease (IBD) can occur at any age. In pediatric patients, the disease may present with a broader range of symptoms and more severe course than in adults, due to ongoing growth and development. Therefore, pedi…
View article: A digest of clinical practice guideline for pediatric IgA vasculitis in Japan 2023
A digest of clinical practice guideline for pediatric IgA vasculitis in Japan 2023 Open
View article: Prevalence and Incidence of Peutz–Jeghers Syndrome and Juvenile Polyposis Syndrome in Japan: A Nationwide Epidemiological Survey in 2022
Prevalence and Incidence of Peutz–Jeghers Syndrome and Juvenile Polyposis Syndrome in Japan: A Nationwide Epidemiological Survey in 2022 Open
Background and Aim Peutz–Jeghers syndrome (PJS) and juvenile polyposis syndrome (JPS) are autosomal dominant diseases associated with high cancer risk. In Japan, knowledge about the prevalence and incidence of PJS and JPS is lacking despit…
View article: High galectin expression in Helicobacter pylori-infected gastric mucosa in childhood
High galectin expression in Helicobacter pylori-infected gastric mucosa in childhood Open
The increased expression of Gal-1 and Gal-9 may suppress Th1 and Th17 immune responses against H. pylori infection during childhood, promote H. pylori colonization, and reduce inflammation in the gastric mucosa of pediatric patients.
View article: Efficacy of sequential fecal-marker examination for evaluating gastrointestinal inflammation in solid food protein-induced enterocolitis syndrome
Efficacy of sequential fecal-marker examination for evaluating gastrointestinal inflammation in solid food protein-induced enterocolitis syndrome Open
Sequential fecal marker examination proved valuable in diagnosing Solid-FPIES and evaluating the degree of gastrointestinal inflammation.
View article: Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature
Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature Open
Although the clinical efficacy of tofacitinib has been reported in adult patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive (Ab+) dermatomyositis, data on its use in refractory juvenile dermatomyositis (…
View article: Modulation of Intestinal Motility in an Adolescent Rat Model of Irritable Bowel Syndrome
Modulation of Intestinal Motility in an Adolescent Rat Model of Irritable Bowel Syndrome Open
Introduction: The pathophysiology of irritable bowel syndrome (IBS) remains unknown. This study aimed to evaluate colonic motility and serotonin system response to restraint stress (RS) among adolescent rats who underwent neo…
View article: Clinical Guidelines for Diagnosis and Management of Juvenile Polyposis Syndrome in Children and Adults-Secondary Publication
Clinical Guidelines for Diagnosis and Management of Juvenile Polyposis Syndrome in Children and Adults-Secondary Publication Open
Juvenile polyposis syndrome (JPS) is a rare disease characterized by multiple hamartomatous polyps within the gastrointestinal tract. SMAD4 or BMPR1A is known as a causative gene of JPS. Approximately 75% of newly diagnosed cases have an a…
View article: Novel Findings of Early Cardiac Dysfunction in Patients With Childhood-Onset Inflammatory Bowel Disease Using Layer-Specific Strain Analysis
Novel Findings of Early Cardiac Dysfunction in Patients With Childhood-Onset Inflammatory Bowel Disease Using Layer-Specific Strain Analysis Open
Background Patients with inflammatory bowel disease (IBD) are at a higher risk of developing cardiovascular diseases than healthy individuals, owing to persistent chronic inflammation and treatment effects. This study aimed to assess left …
View article: Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with <i>SLCO2A1</i> gene: A case report
Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with <i>SLCO2A1</i> gene: A case report Open
EoN should be considered in the differential diagnosis of CEAS-like small intestinal ulcerative lesions and normal urinary prostaglandin metabolite levels.
View article: Correction to: Expert consensus on vaccination in patients with inflammatory bowel disease in Japan
Correction to: Expert consensus on vaccination in patients with inflammatory bowel disease in Japan Open
View article: An Isolated Intestinal Juvenile Polyp Diagnosed by Abdominal Ultrasonography and Resected by Double-Balloon Endoscopy: A Case Report and Literature Review
An Isolated Intestinal Juvenile Polyp Diagnosed by Abdominal Ultrasonography and Resected by Double-Balloon Endoscopy: A Case Report and Literature Review Open
Juvenile polyps, typically localized in the rectum and sigmoid colon, are a common cause of pediatric bloody stool. An isolated small intestinal juvenile polyp is uncommon and generally difficult to diagnose. The first case of an isolated …
View article: Expert consensus on vaccination in patients with inflammatory bowel disease in Japan
Expert consensus on vaccination in patients with inflammatory bowel disease in Japan Open
View article: A Pediatric Case of Inverted Meckel’s Diverticulum Presenting with Cyclic Vomiting-like Symptoms: A Case Report and Literature Review
A Pediatric Case of Inverted Meckel’s Diverticulum Presenting with Cyclic Vomiting-like Symptoms: A Case Report and Literature Review Open
Asymptomatic Meckel’s diverticulum cases are not uncommon, leading to diagnostic difficulties in cases of atypical presentations with only gastrointestinal symptoms other than bloody stool. A nine-year-old boy diagnosed as having cyclic vo…
View article: Impact of Anti-TNFα Treatment on the Humoral Response to the BNT162b2 mRNA COVID-19 Vaccine in Pediatric Inflammatory Bowel Disease Patients
Impact of Anti-TNFα Treatment on the Humoral Response to the BNT162b2 mRNA COVID-19 Vaccine in Pediatric Inflammatory Bowel Disease Patients Open
The efficacy of the COVID-19 mRNA vaccine, including the third vaccination in pediatric inflammatory bowel disease (PIBD) patients is not fully understood. This study aimed to evaluate the humoral immunogenicity of the BNT162b2 vaccine and…
View article: Efficacy of <i>H. pylori</i> eradication therapy on dyspeptic symptoms in childhood
Efficacy of <i>H. pylori</i> eradication therapy on dyspeptic symptoms in childhood Open
機能性ディスペプシア（Functional dyspepsia：FD）は基礎疾患に依らない慢性的な心窩部症状を呈する疾患である．成人領域ではピロリ菌感染に付随するディスペプシアはH. pylori関連ディスペプシア（H. pylori-associated dyspepsia：HpD）と呼ばれているが，小児期の消化器症状とピロリ菌感染との関連性については否定的なエビデンスが多い．実際に，小児におけるピロリ菌感染症の多くは無症状で，消化器症状の発生リスクを増大させない．一方，…
View article: Differentiation of Yersinia enterocolitica enteritis from other bacterial enteritides by ultrasonography: A single-center case–control study
Differentiation of Yersinia enterocolitica enteritis from other bacterial enteritides by ultrasonography: A single-center case–control study Open
Characteristic ultrasonographic findings identified in this study may improve ultrasonographic differentiation of Y. enterocolitica enteritis from other bacterial enteritides.
View article: Evaluating Small Intestinal Motility in a Rat Model of Adolescent Irritable Bowel Syndrome
Evaluating Small Intestinal Motility in a Rat Model of Adolescent Irritable Bowel Syndrome Open
In the rat model of adolescent irritable bowel syndrome with restraint stress, we observed an increase in small intestinal and colonic motility. In the small intestine, enhanced 5-Hydroxytryptamine secretion in the distal portion may be in…
View article: Novel pediatric granulomatosis with polyangiitis with a marked bloody pericardial effusion and bloody stool: a case report
Novel pediatric granulomatosis with polyangiitis with a marked bloody pericardial effusion and bloody stool: a case report Open
Background Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis involving the upper respiratory tract, lungs, kidneys, and systemic small and medium-sized arteries that affects all age groups. No pediatric case wit…
View article: Hydrodynamic generation of skyrmions in a two-component Bose-Einstein condensate
Hydrodynamic generation of skyrmions in a two-component Bose-Einstein condensate Open
When an obstacle is moved in a superfluid faster than a critical velocity, quantized vortices are generated behind the obstacle. Here we propose a method to create more complicated topological excitations, three-dimensional skyrmions, behi…
View article: A Case of Transposition of the Great Arteries that Led to the Development of Non-IgE-Mediated Gastrointestinal Food Allergy after a Neonatal Necrotizing Enterocolitis Complication
A Case of Transposition of the Great Arteries that Led to the Development of Non-IgE-Mediated Gastrointestinal Food Allergy after a Neonatal Necrotizing Enterocolitis Complication Open
新生児壊死性腸炎（neonatal necrotizing enterocolitis: NEC）は新生児期から管理を要する先天性心疾患（congenital heart disease: CHD）児において重要な合併症の一つである．一方，新生児・乳児食物蛋白誘発胃腸症は嘔吐・下痢・血便・腹部膨満などの消化器症状を呈することが多いが，稀に消化管穿孔やNECなどを合併する重症例も散見する．また，CHDと新生児・乳児蛋白誘発胃腸症の関連についても報告され，特に腸管血流が低下する…
View article: Expression of Oncogenic Molecules in Pediatric Ulcerative Colitis
Expression of Oncogenic Molecules in Pediatric Ulcerative Colitis Open
Introduction: Long-term disease duration of ulcerative colitis (UC) is known to increase the risk of developing colorectal cancer in adults; however, this association has not been genetically analyzed in children with UC. Her…
View article: Evaluation of Small Intestinal Motility in a Rat Model of Irritable Bowel Syndrome
Evaluation of Small Intestinal Motility in a Rat Model of Irritable Bowel Syndrome Open
Background: The correlation between small intestinal motility alteration and irritable bowel syndrome (IBS) is not well evaluated. Aims: To assess the small intestinal and colonic transits in an IBS rat model with restraint stress and dete…
View article: Novel Pediatric Granulomatosis with Polyangiitis With a Marked Bloody Pericardial Effusion and Bloody Stool: A Case Report
Novel Pediatric Granulomatosis with Polyangiitis With a Marked Bloody Pericardial Effusion and Bloody Stool: A Case Report Open
Background Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis in the upper respiratory tract, lungs, kidneys, and systemic small and medium-sized arteries; adults and children have similar courses. A pediatric GP…
View article: Novel Pediatric Granulomatosis With Polyangiitis With a Marked Bloody Pericardial Effusion and Bloody Stool: A Case Report
Novel Pediatric Granulomatosis With Polyangiitis With a Marked Bloody Pericardial Effusion and Bloody Stool: A Case Report Open
Background Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis in the upper respiratory tract, lungs, kidneys, and systemic small and medium-sized arteries; adults and children have similar courses. A pediatric GP…
View article: Correction: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy
Correction: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy Open
[This corrects the article DOI: 10.1371/journal.pone.0241869.].
View article: A case of autoimmune enteropathy with CTLA4 haploinsufficiency
A case of autoimmune enteropathy with CTLA4 haploinsufficiency Open
Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, entero…
View article: Effectiveness of Biological Agents in the Treatment of Pediatric Patients with Crohn’s Disease and Anal Fistulae
Effectiveness of Biological Agents in the Treatment of Pediatric Patients with Crohn’s Disease and Anal Fistulae Open
Introduction: Anal fistulae have a significant impact on the quality of life of patients with Crohn’s disease (CD). In this cross-sectional study, we aimed to determine whether biological agents were effective in treating ana…
View article: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy
A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy Open
Chronic enteropathy associated with SLCO2A1 gene (CEAS) is caused by loss-of-function mutations in SLCO2A1 , which encodes a prostaglandin (PG) transporter. In this study, we report a sibling case of CEAS with a novel pathogenic variant of…