Keisuke Okabe
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View article: Yolk sac-derived fetal macrophages suppress skin fibrosis and contribute to scarless wound healing
Yolk sac-derived fetal macrophages suppress skin fibrosis and contribute to scarless wound healing Open
In mice, skin wounds created on embryonic day 13 (E13) regenerate completely, including skin texture restoration; however, after E14, the skin texture does not regenerate, while the dermis regenerates. Furthermore, after E17, neither the t…
View article: Formation of actin mesh structures and alpha-smooth muscle actin dynamics in fibroblasts contribute to dermal regeneration in mouse fetus
Formation of actin mesh structures and alpha-smooth muscle actin dynamics in fibroblasts contribute to dermal regeneration in mouse fetus Open
In adult mammals and other highly developed animals, incomplete wound healing, scar formation, and fibrosis occur. No treatment for complete tissue regeneration is currently available. However, in mice, at up to 13 days of gestation, early…
View article: Novel Concept of “Right-at-the-right-place” Transplantation: Rejuvenating Effects of Mouse Fascial Fibroblasts
Novel Concept of “Right-at-the-right-place” Transplantation: Rejuvenating Effects of Mouse Fascial Fibroblasts Open
Background: Live autologous cultured fibroblasts improve sagging and wrinkles when injected into the dermis; however, their diversity and differences in efficacy depending on the skin layer to which they are transplanted remain unclear. Th…
View article: Role of transforming growth factor-β1 in regulating adipocyte progenitors
Role of transforming growth factor-β1 in regulating adipocyte progenitors Open
View article: Comparison of the Quality of Lymphatic Vessel Images Obtained Using Two Photoacoustic Imaging Systems
Comparison of the Quality of Lymphatic Vessel Images Obtained Using Two Photoacoustic Imaging Systems Open
Summary: Photoacoustic imaging (PAI) can evaluate lymphatic vessels with a high resolution (0.2 mm) compared with other methods. LUB0, a new PAI device that is smaller than the PAI-05 used since 2020 (both from Luxonus, Inc.), has been int…
View article: Rac1 inhibition regenerates wounds in mouse fetuses via altered actin dynamics
Rac1 inhibition regenerates wounds in mouse fetuses via altered actin dynamics Open
View article: Evaluation of Postoperative Anastomotic Patency in Lymphaticovenular Anastomosis Using Photoacoustic Imaging
Evaluation of Postoperative Anastomotic Patency in Lymphaticovenular Anastomosis Using Photoacoustic Imaging Open
Background and Objectives Lymphaticovenular anastomosis (LVA) is a surgical technique used to alleviate lymphedema by bypassing the lymphatic and venous vessels and facilitating lymphatic fluid drainage. Accurate evaluation of anastomotic …
View article: Role of transforming growth factor-β1 in regulating adipocyte progenitors
Role of transforming growth factor-β1 in regulating adipocyte progenitors Open
Adipose tissue (AT) metabolism involves coordinating various cells and cellular processes to regulate energy storage, release, and overall metabolic homeostasis. Therein, macrophage and its cytokine are important in controlling tissue home…
View article: Tunneling nanotube-driven complete regeneration of murine fetal skin
Tunneling nanotube-driven complete regeneration of murine fetal skin Open
View article: Salicylate induces epithelial actin reorganization via activation of the AMP-activated protein kinase and promotes wound healing and contraction in mice
Salicylate induces epithelial actin reorganization via activation of the AMP-activated protein kinase and promotes wound healing and contraction in mice Open
Wounds that occur in adults form scars due to fibrosis, whereas those in embryos regenerate. If wound healing in embryos is mimicked in adults, scarring can be reduced. We found that mouse fetuses could regenerate tissues up to embryonic d…
View article: Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses
Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses Open
Unlike adult mammalian wounds, early embryonic mouse skin wounds completely regenerate and heal without scars. Analysis of the underlying molecular mechanism will provide insights into scarless wound healing. Twist2 is an important regulat…
View article: Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses
Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses Open
Unlike adult mammalian wounds, early embryonic mouse skin wounds completely regenerate and heal without scars. Analysis of the underlying molecular mechanism will provide insights into scarless wound healing. Twist2 is an important regulat…
View article: Preoperative photoacoustic versus indocyanine green lymphography in lymphaticovenular anastomosis outcomes for lower extremity lymphedema: A pilot study
Preoperative photoacoustic versus indocyanine green lymphography in lymphaticovenular anastomosis outcomes for lower extremity lymphedema: A pilot study Open
Background Identification of the proper lymphatics is important for successful lymphaticovenular anastomosis (LVA) for lymphedema; however, visualization of lymphatic vessels is challenging. Photoacoustic lymphangiography (PAL) can help vi…
View article: Regeneration of Panniculus Carnosus Muscle in Fetal Mice Is Characterized by the Presence of Actin Cables
Regeneration of Panniculus Carnosus Muscle in Fetal Mice Is Characterized by the Presence of Actin Cables Open
Mammalian skin, including human and mouse skin, does not regenerate completely after injury; it is repaired, leaving a scar. However, it is known that skin wounds up to a certain stage of embryonic development can regenerate. The mechanism…
View article: Changes in the Distribution of Adiponectin Isoforms within Total Adiponectin in Japanese Subjects with Abdominal Obesity and their Relation to Insulin Resistance and Metabolic Syndrome
Changes in the Distribution of Adiponectin Isoforms within Total Adiponectin in Japanese Subjects with Abdominal Obesity and their Relation to Insulin Resistance and Metabolic Syndrome Open
Changes in the distribution of adiponectin isoforms, especially middle-and low-molecular-weight (MMW, LMW) adiponectin (Ad), within total adiponectin (T-Ad) in subjects with abdominal obesity (AO) and how these changes might be related to …
View article: Compound 13 Promotes Epidermal Healing in Mouse Fetuses via Activation of AMPK
Compound 13 Promotes Epidermal Healing in Mouse Fetuses via Activation of AMPK Open
Unlike adults, early developing fetuses can completely regenerate tissue, and replicating this could lead to the development of treatments to reduce scarring. Mice epidermal structures, including wound healing patterns, are regenerated unt…
View article: Effect of Sonic Hedgehog on the Regeneration of Epidermal Texture Patterns
Effect of Sonic Hedgehog on the Regeneration of Epidermal Texture Patterns Open
Wounds on embryonic mouse fetuses regenerate up to embryonic day (E) 13, but after E14, the pattern is lost and a visible scar remains. We hypothesized that the sonic hedgehog (Shh), which is involved in patterning during development, is i…
View article: Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration Open
Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-adipogenic progenitors (FAPs), and macrophages. How macrophages regulate the paracrine secretion of FAPs during the recovery process remains elusive. Her…
View article: Actin cable formation and epidermis–dermis positional relationship during complete skin regeneration
Actin cable formation and epidermis–dermis positional relationship during complete skin regeneration Open
View article: Mast Cells Are Activated in the Giant Earlobe Keloids: A Case Series
Mast Cells Are Activated in the Giant Earlobe Keloids: A Case Series Open
Mast cells and inflammatory cells are abundant in keloid and hypertrophic scar tissues. Even if the cause of physical injury is similar, such as piercing or scratching with hands, clinical findings show differences in the size of keloids i…
View article: Effect of All-trans Retinoic Acid on Panniculus Carnosus Muscle Regeneration in Fetal Mouse Wound Healing
Effect of All-trans Retinoic Acid on Panniculus Carnosus Muscle Regeneration in Fetal Mouse Wound Healing Open
Background: The dermal panniculus carnosus (PC) muscle is critical for wound contraction in lower mammals and is a useful model of muscle regeneration owing to its high cellular metabolic turnover. During wound healing in mice, skin struct…
View article: A Case of Refractory Sole Ulcer Successfully Treated by Horny and Strong Split-Thickness Skin Graft and an Artificial Dermis with Negative Pressure Wound Therapy
A Case of Refractory Sole Ulcer Successfully Treated by Horny and Strong Split-Thickness Skin Graft and an Artificial Dermis with Negative Pressure Wound Therapy Open
Resurfacing the sole, especially the load part, is demanding, and the gold standard for reconstruction of this part has not been set at present. In this study, we successfully reconstructed a plantar forefoot with repeated calluses and ulc…
View article: Downregulation of Lhx2 Markedly Impairs Wound Healing in Mouse Fetus
Downregulation of Lhx2 Markedly Impairs Wound Healing in Mouse Fetus Open
Multiple transitions occur in the healing ability of the skin during embryonic development in mice. Embryos up to embryonic day 13 (E13) regenerate completely without a scar after full-thickness wounding. Then, up to E16, dermal structures…
View article: Role of Wnt Signaling in Mouse Fetal Skin Wound Healing
Role of Wnt Signaling in Mouse Fetal Skin Wound Healing Open
Wnt proteins secrete glycoproteins that are involved in various cellular processes to maintain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented. Our previ…
View article: Fibroblast Growth Factor 7 Suppresses Fibrosis and Promotes Epithelialization during Wound Healing in Mouse Fetuses
Fibroblast Growth Factor 7 Suppresses Fibrosis and Promotes Epithelialization during Wound Healing in Mouse Fetuses Open
Adult mammalian wounds leave visible scars, whereas skin wounds in developing mouse fetuses are scarless until a certain point in development when complete regeneration occurs, including the structure of the dermis and skin appendages. Ana…
View article: Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects
Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects Open
Nicotinamide mononucleotide (NNM) is an orally bioavailable NAD + precursor that has demonstrated beneficial effects against aging and aging-associated diseases in animal models. NMN is ultimately converted to NAD + , a redox cofactor that…
View article: Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation
Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation Open
Background: Variations in skin healing capacities are observed during different murine embryonic developmental stages. Through embryonic day 16 (E16), embryos are able to regenerate dermal architecture following flank skin wounding; howeve…
View article: Three-dimensional analysis of dermal backflow in cancer-related lymphedema using photoacoustic lymphangiography
Three-dimensional analysis of dermal backflow in cancer-related lymphedema using photoacoustic lymphangiography Open
Background Dermal backflow (DBF), which refers to lymphatic reflux due to lymphatic valve insufficiency, is a diagnostic finding in lymphedema. However, the three-dimensional structure of DBF remains unknown. Photoacoustic lymphangiography…
View article: Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality
Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality Open
Lymphaticovenular anastomosis (LVA) is a widely performed surgical procedure for the treatment of lymphedema. For good LVA outcomes, identifying lymphatic vessels and venules is crucial. Photoacoustic lymphangiography (PAL) is a new techno…
View article: Application of Photoacoustic Imaging for Lymphedema Treatment
Application of Photoacoustic Imaging for Lymphedema Treatment Open
Background Lymphatic vessels are difficult to identify using existing modalities as because of their small diameter and the transparency of the lymph fluid flowing through them. Methods Here, we introduce photoacoustic lymphangiography (PA…