Keisuke Okada
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View article: Global Andrology Forum Clinical Guidelines on the Relevance of Sperm DNA Fragmentation in Reproductive Medicine
Global Andrology Forum Clinical Guidelines on the Relevance of Sperm DNA Fragmentation in Reproductive Medicine Open
While there is growing interest and evidence regarding the clinical benefit of SDF testing and its utility in managing male infertility, significant gaps in the literature limit its routine use in clinical practice. The guidelines offer a …
View article: Possible mechanisms of spermatogenic dysfunction induced by viral infections: Insights from <scp>COVID</scp> ‐19
Possible mechanisms of spermatogenic dysfunction induced by viral infections: Insights from <span>COVID</span> ‐19 Open
Background As the COVID‐19 pandemic nears resolution in 2024, the mechanisms by which SARS‐CoV‐2 and other viral infections induce spermatogenic dysfunction remain poorly understood. This review examines the mechanisms by which viral infec…
View article: Consideration of treatment goals and termination algorithm for adolescent atopic dermatitis using upadacitinib
Consideration of treatment goals and termination algorithm for adolescent atopic dermatitis using upadacitinib Open
Objectives Standardized criteria for disease activity and end of treatment of systemic treatment of atopic dermatitis have not been established. The objective of this study is to explore the experience using upadacitinib retrospectively, t…
View article: Comparative clinical trials with a novel approach: Utilizing the shiny method for investigational urothelial carcinoma therapies
Comparative clinical trials with a novel approach: Utilizing the shiny method for investigational urothelial carcinoma therapies Open
None declared.
View article: Premature Chromatid Separation Trait Found During the Diagnosis of Male Infertility: A Case Report
Premature Chromatid Separation Trait Found During the Diagnosis of Male Infertility: A Case Report Open
Premature chromatid separation (PCS)/mosaic variegated aneuploidy (MVA) syndrome is a rare chromosome instability syndrome. This syndrome is inherited in an autosomal recessive pattern. Although heterozygous carriers of a monoallelic mutat…
View article: Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data Open
Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-per…
View article: A case of renal cell carcinoma in the contralateral kidney with TFE3 gene translocation following successful treatment of nephroblastoma
A case of renal cell carcinoma in the contralateral kidney with TFE3 gene translocation following successful treatment of nephroblastoma Open
A case of renal cell carcinoma in the contralateral kidney withTFE3 gene translocation following successful treatment of nephroblastomaShunsuke Fujisawa1), Junya Furukawa1), Takuto Hara1), Keiske Okada1), Kouji Chiba1),Yuzo Nakano1), Toshi…
View article: Improvement in semen parameters by switching steroids in a male congenital adrenal hyperplasia patient with severe oligozoospermia
Improvement in semen parameters by switching steroids in a male congenital adrenal hyperplasia patient with severe oligozoospermia Open
Congenital adrenal hyperplasia (CAH) causes hypogonadotropic hypogonadism due to the excessive production of adrenal androgens, which results in hypospermatogenesis in some male patients. We herein present a CAH case with hypogonadotropic …
View article: Dimethyl Fumarate Protects Rats against Testicular Ischemia–Reperfusion Injury
Dimethyl Fumarate Protects Rats against Testicular Ischemia–Reperfusion Injury Open
Ischemia–reperfusion injury (IRI) after testicular torsion is linked to significant damage in testicular tissue. Dimethyl fumarate (DMF) activates the nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling pathway, thereby inducing a…
View article: Effects of <i>Bifidobacterium longum</i> CLA8013 on bowel movement improvement: a placebo-controlled, randomized, double-blind study
Effects of <i>Bifidobacterium longum</i> CLA8013 on bowel movement improvement: a placebo-controlled, randomized, double-blind study Open
A placebo-controlled, randomized, double-blind study was conducted to evaluate the effect of taking 25 billion colony-forming units of heat-killed Bifidobacterium longum CLA8013 over 2 weeks on bowel movements in constipation-prone healthy…
View article: Safety Evaluations of Long-Term and Excessive Intakes of &lt;i&gt;Bifidobacterium longum&lt;/i&gt; CLA8013: A Placebo-Controlled, Randomized, Double-Blind Study
Safety Evaluations of Long-Term and Excessive Intakes of <i>Bifidobacterium longum</i> CLA8013: A Placebo-Controlled, Randomized, Double-Blind Study Open
Heat-killed Bifidobacterium longum CLA8013 has been demonstrated to improve the frequency of defecation, straining, and pain during defecation in human placebo-controlled, double-blind, parallel-group studies. We conducted a randomized, do…
View article: Consensus and Diversity in the Management of Varicocele for Male Infertility: Results of a Global Practice Survey and Comparison with Guidelines and Recommendations
Consensus and Diversity in the Management of Varicocele for Male Infertility: Results of a Global Practice Survey and Comparison with Guidelines and Recommendations Open
This study is the largest global survey performed to date on the clinical management of varicocele for male infertility. It demonstrates: 1) a wide disagreement in the approach to varicocele management, 2) large gaps in the clinical practi…
View article: The Effects of Branched-Chain Amino Acids on the Akt/mTOR Pathway and Nebulin Protein in Joint Fixation-Induced Muscle Atrophy
The Effects of Branched-Chain Amino Acids on the Akt/mTOR Pathway and Nebulin Protein in Joint Fixation-Induced Muscle Atrophy Open
It is well known that branched-chain amino acids (BCAAs) promote protein synthesis in skeletal muscle and can cause muscle hypertrophy. However, it has also been reported that they may inhibit muscle atrophy induced by load-bearing and age…
View article: Effect of Aging on Skeletal Muscle Regeneration in Rats
Effect of Aging on Skeletal Muscle Regeneration in Rats Open
[Purpose] This study investigated the effect of aging on muscle regeneration in rats. [Participants and Methods] Male Wistar rats were divided into 3 groups of 10-week-old, 24-week-old, and 95-week-old animals. We administered a cardiotoxi…
View article: Long‐term wheel‐running prevents reduction of grip strength in type 2 diabetic rats
Long‐term wheel‐running prevents reduction of grip strength in type 2 diabetic rats Open
Diabetic skeletal muscles show reduced contractile force and increased fatigability. Hands are a target for several diabetes-induced complications. Therefore, reduced handgrip strength often occurs as a consequence of diabetes. The aim of …
View article: A case of prostate stromal sarcoma involving the rectum
A case of prostate stromal sarcoma involving the rectum Open
Sarcomas and related proliferative lesions of the specialized stroma of the prostate are very rare and have been classified into prostate stromal sarcoma (PSS) and prostatic stromal tumor of uncertain malignant potential based on histology…
View article: Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition
Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition Open
The complex between Trm7 and Trm734 (Trm7–Trm734) from Saccharomyces cerevisiae catalyzes 2′-O-methylation at position 34 in tRNA. We report biochemical and structural studies of the Trm7–Trm734 complex. Purified recombinant Trm7–Trm734 pr…
View article: Raftophilic rhodopsin-clusters offer stochastic platforms for G protein signalling in retinal discs
Raftophilic rhodopsin-clusters offer stochastic platforms for G protein signalling in retinal discs Open
Rhodopsin is a G protein-coupled receptor (GPCR) that initiates the phototransduction cascade in retinal disc membrane. Recent studies have suggested that rhodopsin forms highly ordered rows of dimers responsible for single-photon detectio…
View article: MP01-17 HOW TO MAKE SURGEON EDUCATIONAL SYSTEM FOR TRANSURETHRAL SURGERY FOR BENIGN PROSTATE HYPERPLASIA?
MP01-17 HOW TO MAKE SURGEON EDUCATIONAL SYSTEM FOR TRANSURETHRAL SURGERY FOR BENIGN PROSTATE HYPERPLASIA? Open
You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy & New Technology I (MP01)1 Apr 2019MP01-17 HOW TO MAKE SURGEON EDUCATIONAL SYSTEM FOR TRANSURETHRAL SURGERY FOR BENIGN PROSTATE HYPERPLASIA? Katsumi Shigemura*…
View article: 【Original Contribution】Molecular Simulation of Adsorption Behavior of a Silica Nanoparticle onto a Polymeric Membrane Surface in Water
【Original Contribution】Molecular Simulation of Adsorption Behavior of a Silica Nanoparticle onto a Polymeric Membrane Surface in Water Open
Molecular dynamics (MD) simulation was used to evaluate the effect of the interaction between polymer membrane and a silica nanoparticle (SNP), and the influence of polymer membrane surface properties on adsorbing behavior of SNP. In MD si…
View article: Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and Radiotherapy
Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and Radiotherapy Open
The survival rates of boys and men with cancer have increased due to advances in cancer treatments; however, maintenance of quality of life, including fertility preservation, remains a major issue. Fertile male patients who receive radiati…
View article: The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis
The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis Open
Bordetella pertussis , Bordetella bronchiseptica , and Bordetella parapertussis share highly homologous virulence factors and commonly cause respiratory infections in mammals; however, their host specificities and disease severities differ…
View article: PD33-10 HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED TESTOSTERONE-PRODUCING LEYDIG CELLS AMELIORATE SERUM TESTOSTERONE LEVEL IN RATS.
PD33-10 HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED TESTOSTERONE-PRODUCING LEYDIG CELLS AMELIORATE SERUM TESTOSTERONE LEVEL IN RATS. Open
You have accessJournal of UrologyStem Cell Research: Stem Cell Research I1 Apr 2018PD33-10 HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED TESTOSTERONE-PRODUCING LEYDIG CELLS AMELIORATE SERUM TESTOSTERONE LEVEL IN RATS. Takaki Ishida, Mikito T…
View article: MP60-02 MOLECULAR CHANGES INDUCED BY MIRABEGRON IN RAT SERTOLI CELL PRIMARY CULTURE
MP60-02 MOLECULAR CHANGES INDUCED BY MIRABEGRON IN RAT SERTOLI CELL PRIMARY CULTURE Open
You have accessJournal of UrologyInfertility: Basic Research & Pathophysiology1 Apr 2018MP60-02 MOLECULAR CHANGES INDUCED BY MIRABEGRON IN RAT SERTOLI CELL PRIMARY CULTURE Mikito Tanaka, Koji Chiba, Takaki Ishida, Kenta Sumii, Teruo Fukuda…