Explanipedia

Potential Involvement of Myostatin in Smooth Muscle Differentiation in Pleomorphic Leiomyosarcoma Open

Hiroko Onagi, Raku Son, Akiko Oguchi, Kei Sano, Keita Sasa , et al. · 2025

High-grade sarcomas often lack typical morphological features and exhibit no clear differentiation, often leading to a diagnosis of undifferentiated sarcoma (US). Pleomorphic leiomyosarcoma (PLMS) is a high-grade sarcoma consisting of a ty…

NTRK2 expression in gastrointestinal stromal tumors with a special emphasis on the clinicopathological and prognostic impacts Open

Keita Sasa, Raku Son, Akiko Oguchi, Karin Ashizawa, Nobuhiko Hasegawa , et al. · 2024

Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing Open

Nobuhiko Hasegawa, Takuo Hayashi, Hidetaka Niizuma, Kazutaka Kikuta, Jungo Imanishi , et al. · 2023

Background Approximately 1% of clinically treatable tyrosine kinase fusions, including anaplastic lymphoma kinase, neurotrophic tyrosine receptor kinase, RET proto-oncogene, and ROS proto-oncogene 1, have been identified in soft tissue sar…

Endoplasmic Reticulum Stress in Osteosarcoma: IRE1α-XBP1 Inhibition Exerts Anti-Tumor Activity Open

Keita Sasa, Tsuyoshi Saito, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano , et al. · 2022

Aim: Osteosarcoma (OS) is the most common primary malignant bone tumor.However, the clinical course of the advanced cases at the first visit are still extremely poor.Recently, studies have explored the therapeutic effects of targeting endo…

Microcystic/reticular schwannoma of the lower leg: Case report with review of literature Open

Tsuyoshi Saito, Daisuke Kubota, Keita Sasa, Nobuhiko Hasegawa, Takuo Hayashi , et al. · 2022

Introduction: Microcystic/reticular schwannoma is a distinctive histopathological variant of schwannoma, which is rare. Its occurrence in the subcutaneous soft tissue of the lower extremity has rarely been reported. Case Report: We report …

Retraction Note to: IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma Open

Keita Sasa, Tsuyoshi Saito, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano , et al. · 2022

Establishment of Rapid and Accurate Screening System for Molecular Target Therapy of Osteosarcoma Open

Keita Sasa, Tsuyoshi Saito, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano , et al. · 2022

Introduction Comprehensive analyses using clinical sequences subcategorized osteosarcoma (OS) into several groups according to the activated signaling pathways. Mutually exclusive co-occurrences of gene amplification ( PDGFRA/KIT/KDR, VEGF…

RETRACTED ARTICLE: IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma Open

Keita Sasa, Tsuyoshi Saito, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano , et al. · 2021

Inflammatory fibroid polyp of the ileum with stroma rich in lymphovascular structures Open

Yuya Yamashiro, Tsuyoshi Saito, Takuo Hayashi, Keita Sasa, Makoto Takahashi , et al. · 2021

Inflammatory fibroid polyp (IFP) is a rare and benign tumor of the gastrointestinal (GI) tract that harbors PDGFRA mutations. PDGFRA alterations are also found in subsets of other GI tract mesenchymal tumors, such as KIT-negative gastroint…

Nodular fasciitis adjacent to the left humerus in a 15-year-old boy Open

Keita Sasa, Yoshiyuki Suehara, Tatsuya Takagi, Kei Sano, Takuo Hayashi , et al. · 2021

Correction to: A case of primary distal-type epithelioid sarcoma of the lumbar vertebra with a review of literature Open

Ayako Ura, Tsuyoshi Saito, Toru Motoi, Tatsuya Takagi, Yoshiyuki Suehara , et al. · 2020

Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma Open

Yoshiyuki Suehara, Shinji Kohsaka, Takuo Hayashi, Keisuke Akaike, Aiko Kurisaki‐Arakawa , et al. · 2020

Background Soft tissue sarcomas are a heterogeneous group of rare malignant tumors. Advanced soft tissue sarcomas have a poor prognosis, and effective systemic therapies have not been established. Tyrosine kinases are increasingly being us…

74P Comprehensive transcriptome analysis of endoplasmic reticulum stress in osteosarcomas Open

Yoshiyuki Suehara, Taisei Kurihara, Takuo Hayashi, Kei Sano, Keita Sasa , et al. · 2020

Nanostring-based screening for tyrosine kinase fusions in inflammatory myofibroblastic tumors Open

Taisei Kurihara, Yoshiyuki Suehara, Keisuke Akaike, Takuo Hayashi, Shinji Kohsaka , et al. · 2020

Diffuse expression of MUC6 defines a distinct clinicopathological subset of pulmonary invasive mucinous adenocarcinoma Open

Satsuki Kishikawa, Takuo Hayashi, Tsuyoshi Saito, Kazuya Takamochi, Shinji Kohsaka , et al. · 2020

Invasive mucinous adenocarcinoma (IMA) of the lung is a unique variant of lung adenocarcinoma. Aberrant mucin expression is associated with cancer development and metastasis. However, the clinicopathological significance of mucin expressio…

Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas Open

Yoshiyuki Suehara, Shinji Kohsaka, Shigeo Yamaguchi, Takuo Hayashi, Taisei Kurihara , et al. · 2020

Background Soft-tissue sarcomas are a rare group of malignant tumors that usually are treated with surgical excision and radiation therapy, but recently, pazopanib, an oral tyrosine kinase inhibitor, has been used in patients with metastas…

Preoperative denosumab treatment with curettage may be a risk factor for recurrence of giant cell tumor of bone Open

Kei Sano, Yoshiyuki Suehara, Taketo Okubo, Keita Sasa, Taisei Kurihara , et al. · 2020

Purpose: Giant cell tumor of bone (GCTB) is a local aggressive bone tumor, histologically classified as intermediate malignancy. Recently, the RANKL inhibitor, denosumab, was developed as a novel and effective treatment option for GCTB. Si…

Comparative analysis of protein profiles of prognosis-associated proteins and KIT-related proteins in gastrointestinal stromal tumour Open

Yoshiyuki Suehara, Keita Sasa, Taketo Okubo, Takuo Hayashi, Kei Sano , et al. · 2019

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