Keith A. Delman
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View article: 527 Primary results with long-term follow up of a phase II study of neoadjuvant and adjuvant cemiplimab in high-risk resectable cutaneous squamous cell carcinoma
527 Primary results with long-term follow up of a phase II study of neoadjuvant and adjuvant cemiplimab in high-risk resectable cutaneous squamous cell carcinoma Open
View article: 22 Neoadjuvant pepinemab enhances immune checkpoint blockade in metastatic melanoma characterized by biomarkers of TME reprogramming including tertiary lymphoid structures
22 Neoadjuvant pepinemab enhances immune checkpoint blockade in metastatic melanoma characterized by biomarkers of TME reprogramming including tertiary lymphoid structures Open
View article: Gene Expression Profile–Based Test to Predict Melanoma Sentinel Node Status
Gene Expression Profile–Based Test to Predict Melanoma Sentinel Node Status Open
Importance Contemporary guidelines recommend sentinel lymph node biopsy (SLNB) for patients with melanoma with predicted risk of SLN metastasis greater than 10% and consideration of SLNB when the risk is 5% to 10%. A gene expression profil…
View article: 466 Th17 polarization generates high quality resident memory-like TIL from patients with advanced melanoma
466 Th17 polarization generates high quality resident memory-like TIL from patients with advanced melanoma Open
View article: Society of Surgical Oncology Consensus Statement: Assessing the Evidence for and Utility of Gene Expression Profiling of Primary Cutaneous Melanoma
Society of Surgical Oncology Consensus Statement: Assessing the Evidence for and Utility of Gene Expression Profiling of Primary Cutaneous Melanoma Open
View article: The diagnostic challenges of differentiating metastatic extramammary Paget disease and prostatic adenocarcinoma: A case report and review of the literature
The diagnostic challenges of differentiating metastatic extramammary Paget disease and prostatic adenocarcinoma: A case report and review of the literature Open
View article: Standard Setting for the CGSO Qualifying Examination: A Structured Approach Setting a Meaningful Standard
Standard Setting for the CGSO Qualifying Examination: A Structured Approach Setting a Meaningful Standard Open
View article: Piloting a National Curricular Resource for the Transition to Surgical Residency: Characteristics of Participating Schools and Their Students
Piloting a National Curricular Resource for the Transition to Surgical Residency: Characteristics of Participating Schools and Their Students Open
Many U.S. LCME-accredited medical schools piloted this national TTR surgery curriculum. School-level characteristics associated with pilot participation can inform outreach efforts to encourage the participation of interested schools in pi…
View article: 629 Neoadjuvant SEMA4D inhibitor pepinemab combination with nivolumab increases crosstalk between B cell and CD26<sup>hi</sup> T cell in patients with resectable stage III melanoma
629 Neoadjuvant SEMA4D inhibitor pepinemab combination with nivolumab increases crosstalk between B cell and CD26<sup>hi</sup> T cell in patients with resectable stage III melanoma Open
Background Semaphorin4D (SEMA4D) regulates immune cell infiltration and suppressive features of myeloid cells in the tumor via engaging with receptors, PLXNB1/2 and CD72.1 In preclinical and clinical studies, SEMA4D blockade enh…
View article: 398 Utilizing a Th17 polarization strategy for generating high quality human TIL products for patients with advanced solid tumors
398 Utilizing a Th17 polarization strategy for generating high quality human TIL products for patients with advanced solid tumors Open
Background Tumor infiltrating lymphocyte (TIL) therapy, a form of adoptive cell therapy (ACT), is based on the notion that T cells in the tumor are antigen-specific, and that by culturing them ex vivo, they can be expanded to large …
View article: Impact of Reconstruction on Oncologic Outcomes for Patients with Melanoma after Wide Local Excision: A High-Volume, Quaternary-Referral Center Experience
Impact of Reconstruction on Oncologic Outcomes for Patients with Melanoma after Wide Local Excision: A High-Volume, Quaternary-Referral Center Experience Open
Purpose: There are limited data on the impact of reconstructive surgery on oncologic outcomes in patients with melanoma who undergo wide local excision (WLE). We sought to evaluate the association of reconstruction with recurrence patterns…
View article: HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy
HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy Open
This study provides new insights into the contributions of different CD4 + and CD8 + T-cell subsets to the anatomic differences between LN and blood in individuals with HIV who have optimal versus suboptimal CD4 + T-cell recovery. To our k…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: 613 Neoadjuvant SEMA4D blockade with nivolumab alters suppressive myeloid cells while elevating B cell and CD26<sup>hi</sup> T cell infiltration in the tumors of patients with resectable stage III melanoma
613 Neoadjuvant SEMA4D blockade with nivolumab alters suppressive myeloid cells while elevating B cell and CD26<sup>hi</sup> T cell infiltration in the tumors of patients with resectable stage III melanoma Open
Background Semaphorin 4D (SEMA4D) modulates suppressive myeloid cells to promote infiltration of effector immune populations into the tumor microenvironment (TME). When combined with immune checkpoint blockade (ICB), SEMA4D blockade limits…
View article: Do Oncologic Outcomes From Head and Neck Versus Truncal and Extremity Melanoma Differ? A Single-Institution Single-Subspecialty Experience
Do Oncologic Outcomes From Head and Neck Versus Truncal and Extremity Melanoma Differ? A Single-Institution Single-Subspecialty Experience Open
Background Outcomes are thought to be worse in head and neck (H&N) melanoma patients. However, definitive evidence of inferior outcomes in H&N melanoma in the modern era is lacking. We sought to ascertain whether H&N melanomas carry a wors…
View article: Ford Versus Ferrari: Novel Technologies in the Setting of a Reliable Standard
Ford Versus Ferrari: Novel Technologies in the Setting of a Reliable Standard Open
View article: Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART
Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART Open
Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets c…
View article: Clinical Case-Conference Blogs: Integrating Clinical Librarians to Enhance Resident Education and Enforce ACGME Competencies
Clinical Case-Conference Blogs: Integrating Clinical Librarians to Enhance Resident Education and Enforce ACGME Competencies Open
View article: Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia
Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia Open
View article: Correction to: Merkel Cell Carcinoma Outcomes: Does AJCC8 Underestimate Survival?
Correction to: Merkel Cell Carcinoma Outcomes: Does AJCC8 Underestimate Survival? Open
View article: Implications of COVID-19 on the General Surgery Match
Implications of COVID-19 on the General Surgery Match Open
The COVID-19 pandemic will have lasting implications that span the breadth of healthcare in the years to come. As a byproduct of multiple factors, including supply chain preservation, potential for asymptomatic spread, and a desire to mini…
View article: Introducing the “Virtual Tumor Board” series in <i>CA: A Cancer Journal for Clinicians</i>
Introducing the “Virtual Tumor Board” series in <i>CA: A Cancer Journal for Clinicians</i> Open
CA: A Cancer Journal for Clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care.
View article: Surgical Considerations and Systemic Therapy of Melanoma
Surgical Considerations and Systemic Therapy of Melanoma Open
View article: A Call to Arms: Surgeons Must Play an Important and Early Role in the Management of Patients with Advanced Melanoma
A Call to Arms: Surgeons Must Play an Important and Early Role in the Management of Patients with Advanced Melanoma Open
View article: Lung Surveillance Strategy for High-Grade Soft Tissue Sarcomas: Chest X-Ray or CT Scan?
Lung Surveillance Strategy for High-Grade Soft Tissue Sarcomas: Chest X-Ray or CT Scan? Open
In this large multicenter study, lung surveillance with CXR did not result in worse overall survival compared with CT. With considerable savings, a CXR-based protocol can optimize resource use for lung surveillance in high-grade soft tissu…
View article: Long–Term Oncologic Outcomes After Isolated Limb Infusion for Locoregionally Metastatic Melanoma: An International Multicenter Analysis
Long–Term Oncologic Outcomes After Isolated Limb Infusion for Locoregionally Metastatic Melanoma: An International Multicenter Analysis Open
View article: Survey of Surgical Oncology Fellowship Graduates 2005–2016: Insight into Initial Practice
Survey of Surgical Oncology Fellowship Graduates 2005–2016: Insight into Initial Practice Open
View article: Neoadjuvant therapy of locally/regionally advanced melanoma
Neoadjuvant therapy of locally/regionally advanced melanoma Open
Locally/regionally advanced melanoma confers a major challenge in terms of surgical and medical management. Surgical treatment carries the risks of surgical morbidities and potential complications that could be lasting. In addition, these …
View article: Increase in PD-L1 expression after pre-operative radiotherapy for soft tissue sarcoma
Increase in PD-L1 expression after pre-operative radiotherapy for soft tissue sarcoma Open
Soft tissue sarcomas (STS) have minimal expression of PD-L1, a biomarker for PD-1 therapy efficacy. Radiotherapy (RT) has been shown to increase PD-L1 expression pre-clinically. We examined the expression of PD-L1, pre- and post-RT, in 46 …
View article: Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients
Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients Open
The GEP test is an objective predictor of metastatic risk and provides additional independent prognostic information to traditional staging to help estimate an individual's risk for recurrence. The assay identified 70% of stage I and II pa…