Keith Beadle
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View article: Perivascular cells function as key mediators of mechanical and structural changes in vascular capillaries
Perivascular cells function as key mediators of mechanical and structural changes in vascular capillaries Open
A hallmark of chronic and inflammatory diseases is the formation of a fibrotic and stiff extracellular matrix (ECM), typically associated with abnormal, leaky microvascular capillaries. Mechanisms explaining how the microvasculature respon…
View article: Perivascular cells function as mechano-structural sensors of vascular capillaries
Perivascular cells function as mechano-structural sensors of vascular capillaries Open
A wide range of conditions, including chronic inflammatory diseases and cancer, are characterized by the fibrotic microarchitecture and increased stiffness of collagen type I extracellular matrix. These conditions are typically accompanied…
View article: Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice
Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice Open
Niemann–Pick C1 disease (NPC1) is a rare, fatal neurodegenerative disease caused by mutations in NPC1 , which encodes the lysosomal cholesterol transport protein NPC1. Disease pathology involves lysosomal accumulation of cholesterol and li…
View article: Microbiota regulate social behaviour via stress response neurons in the brain
Microbiota regulate social behaviour via stress response neurons in the brain Open
View article: Systemic AAV vectors for widespread and targeted gene delivery in rodents v2
Systemic AAV vectors for widespread and targeted gene delivery in rodents v2 Open
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel A…
View article: Systemic AAV vectors for widespread and targeted gene delivery in rodents v1
Systemic AAV vectors for widespread and targeted gene delivery in rodents v1 Open
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel A…
View article: Publisher Correction: Systemic AAV vectors for widespread and targeted gene delivery in rodents
Publisher Correction: Systemic AAV vectors for widespread and targeted gene delivery in rodents Open
View article: The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress Open