Alice K. Jacobs
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View article: Development of leptospiral virulence-modifying protein detection assay: implications for pathogenesis and diagnostic test development
Development of leptospiral virulence-modifying protein detection assay: implications for pathogenesis and diagnostic test development Open
Leptospirosis, a globally significant neglected tropical disease, continues to lack early and reliable diagnostic methods despite over a century since the discovery of the disease and its etiological agent. Previously, we identified the pa…
View article: Treatment Times and In-Hospital Mortality Among Patients with ST-Elevation Myocardial Infarction Throughout the Waves of the COVID-19 Pandemic: Lessons Learned
Treatment Times and In-Hospital Mortality Among Patients with ST-Elevation Myocardial Infarction Throughout the Waves of the COVID-19 Pandemic: Lessons Learned Open
Previous studies about the COVID-19 pandemic on STEMI patient outcomes have conflicting results. It remains unclear if this may be attributed to regional differences and/or differences during COVID-19 wave periods. Using the American Heart…
View article: Histopathology-based protein multiplex generation using deep learning
Histopathology-based protein multiplex generation using deep learning Open
View article: Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma
Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma Open
View article: Advancing In-Hospital Mortality Prediction for Acute Myocardial Infarction: an analysis from the American Heart Association Get-With-the-Guidelines Coronary Artery Disease Registry
Advancing In-Hospital Mortality Prediction for Acute Myocardial Infarction: an analysis from the American Heart Association Get-With-the-Guidelines Coronary Artery Disease Registry Open
Background Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with acute myocardial infarction (AMI) contributing to over 100,000 deaths annually in the United States. Accurate risk stratification for in-hospita…
View article: Treatment Times and In-Hospital Mortality Among Patients with ST-Elevation Myocardial Infarction Throughout the Waves of the COVID-19 Pandemic: Lessons Learned
Treatment Times and In-Hospital Mortality Among Patients with ST-Elevation Myocardial Infarction Throughout the Waves of the COVID-19 Pandemic: Lessons Learned Open
Previous studies about the COVID-19 pandemic on STEMI patient outcomes have conflicting results. It remains unclear if this may be attributed to regional differences and/or differences during COVID-19 wave periods. Using the American Heart…
View article: Temporary Emergency Guidance to STEMI Systems of Care During the COVID-19 Pandemic: AHA's Mission: Lifeline
Temporary Emergency Guidance to STEMI Systems of Care During the COVID-19 Pandemic: AHA's Mission: Lifeline Open
The American Heart Association (AHA) Get With The Guidelines Coronary Artery Disease Advisory Work Group, and the Acute Care and Interventional Science Subcommittees of the AHA Council on Clinical Cardiology, are responding to the call of …
View article: Feasibility of multiomics tumor profiling for guiding treatment of melanoma
Feasibility of multiomics tumor profiling for guiding treatment of melanoma Open
There is limited evidence supporting the feasibility of using omics and functional technologies to inform treatment decisions. Here we present results from a cohort of 116 melanoma patients in the prospective, multicentric observational Tu…
View article: Standardization of Suspension and Imaging Mass Cytometry Single‐Cell Readouts for Clinical Decision Making
Standardization of Suspension and Imaging Mass Cytometry Single‐Cell Readouts for Clinical Decision Making Open
Suspension and imaging mass cytometry are single‐cell, proteomic‐based methods used to characterize tissue composition and structure. Data assessing the consistency of these methods over an extended period of time are still sparse and are …
View article: Race-Based Differences in ST-Segment–Elevation Myocardial Infarction Process Metrics and Mortality From 2015 Through 2021: An Analysis of 178 062 Patients From the American Heart Association Get With The Guidelines–Coronary Artery Disease Registry
Race-Based Differences in ST-Segment–Elevation Myocardial Infarction Process Metrics and Mortality From 2015 Through 2021: An Analysis of 178 062 Patients From the American Heart Association Get With The Guidelines–Coronary Artery Disease Registry Open
BACKGROUND: Systems of care have been developed across the United States to standardize care processes and improve outcomes in patients with ST-segment-elevation myocardial infarction (STEMI). The effect of contemporary STEMI systems of ca…
View article: HcAI Bootcamp: Innovating Healthcare via Human-centred AI design approach
HcAI Bootcamp: Innovating Healthcare via Human-centred AI design approach Open
View article: Characteristic and Outcomes of Patients with ST-segment Elevation Myocardial Infarction who have Non-System Reasons for Delay in Treatment: A Report from the AHA GWTG CAD Registry
Characteristic and Outcomes of Patients with ST-segment Elevation Myocardial Infarction who have Non-System Reasons for Delay in Treatment: A Report from the AHA GWTG CAD Registry Open
Background The past two decades have witnessed reductions in time to diagnosis and reperfusion therapy in patients with ST elevation myocardial infarction (STEMI), largely through improvements in STEMI systems of care. While studies have d…
View article: Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia Open
View article: Corrosion of Lithium-ion Battery Cylindrical Cell Hardware: Understanding the Mechanisms and Exploring Effective Solutions
Corrosion of Lithium-ion Battery Cylindrical Cell Hardware: Understanding the Mechanisms and Exploring Effective Solutions Open
We present a detailed examination of Ni corrosion in lithium-ion battery Ni-coated steel cylindrical cell hardware, focusing on LiPF 6 -based electrolytes contaminated with water. The corrosion potential of the cell hardware is predominant…
View article: Probabilistic pathway-based multimodal factor analysis
Probabilistic pathway-based multimodal factor analysis Open
Motivation Multimodal profiling strategies promise to produce more informative insights into biomedical cohorts via the integration of the information each modality contributes. To perform this integration, however, the development of nove…
View article: Mortality differences among patients with in-hospital ST-elevation myocardial infarction
Mortality differences among patients with in-hospital ST-elevation myocardial infarction Open
Background: In-hospital ST-elevation myocardial infarction (STEMI) is associated with a higher mortality rate than out-of-hospital STEMI. Quality measures and universal protocols for treatment of in-hospital STEMI do not exist, likely cont…
View article: Immunogenicity, Efficacy, and Safety of a Novel Synthetic Microparticle Pre-Erythrocytic Malaria Vaccine in Multiple Host Species
Immunogenicity, Efficacy, and Safety of a Novel Synthetic Microparticle Pre-Erythrocytic Malaria Vaccine in Multiple Host Species Open
We previously reported a protective antibody response in mice immunized with synthetic microparticle vaccines made using layer-by-layer fabrication (LbL-MP) and containing the conserved T1BT* epitopes from the P. falciparum circumsporozoit…
View article: Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer
Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer Open
Understanding the complex background of cancer requires genotype-phenotype information in single-cell resolution. Here, we perform long-read single-cell RNA sequencing (scRNA-seq) on clinical samples from three ovarian cancer patients pres…
View article: 546 Conversion of exocrine pancreatic insufficiency in children on CFTR modulator therapy: one cystic fibrosis center’s experience
546 Conversion of exocrine pancreatic insufficiency in children on CFTR modulator therapy: one cystic fibrosis center’s experience Open
View article: Race-Based Differences in ST-Segment–Elevation Myocardial Infarction Process Metrics and Mortality From 2015 Through 2021: An Analysis of 178 062 Patients From the American Heart Association Get With The Guidelines–Coronary Artery Disease Registry
Race-Based Differences in ST-Segment–Elevation Myocardial Infarction Process Metrics and Mortality From 2015 Through 2021: An Analysis of 178 062 Patients From the American Heart Association Get With The Guidelines–Coronary Artery Disease Registry Open
BACKGROUND: Systems of care have been developed across the United States to standardize care processes and improve outcomes in patients with ST-segment–elevation myocardial infarction (STEMI). The effect of contemporary STEMI systems of ca…
View article: Standardization of suspension and imaging mass cytometry readouts for clinical decision making
Standardization of suspension and imaging mass cytometry readouts for clinical decision making Open
Summary Suspension and imaging mass cytometry are single-cell, proteomic-based methods used to characterize tissue composition and structure. Data assessing the consistency of these methods over an extended period of time are still sparse …
View article: Process Outcome Integration with Theory (POInT): academic report
Process Outcome Integration with Theory (POInT): academic report Open
This paper describes the development and testing of a novel approach to evaluating development interventions – the POInT approach. The authors used Bayesian causal modelling to integrate process and outcome data to generate insights about …
View article: Short-term Deaths After Percutaneous Coronary Intervention Discharge: Prevalence, Risk Factors, and Hospital Risk-Adjusted Mortality
Short-term Deaths After Percutaneous Coronary Intervention Discharge: Prevalence, Risk Factors, and Hospital Risk-Adjusted Mortality Open
A large percentage of early deaths after PCI occur after discharge, particularly among lower-risk patients. Future efforts should be focused on monitoring these patients. Hospital risk-adjusted mortality assessments are impacted substantia…
View article: Microparticle RSV Vaccines Presenting the G Protein CX3C Chemokine Motif in the Context of TLR Signaling Induce Protective Th1 Immune Responses and Prevent Pulmonary Eosinophilia Post-Challenge
Microparticle RSV Vaccines Presenting the G Protein CX3C Chemokine Motif in the Context of TLR Signaling Induce Protective Th1 Immune Responses and Prevent Pulmonary Eosinophilia Post-Challenge Open
Layer-by-layer microparticle (LbL-MP) fabrication was used to produce synthetic vaccines presenting a fusion peptide containing RSV G protein CX3C chemokine motif and a CD8 epitope of the RSV matrix protein 2 (GM2) with or without a covale…
View article: Emergency Interhospital Transfer of Patients With ST‐Segment–Elevation Myocardial Infarction: Call 9‐1‐1—The American Heart Association Mission: Lifeline Program
Emergency Interhospital Transfer of Patients With ST‐Segment–Elevation Myocardial Infarction: Call 9‐1‐1—The American Heart Association Mission: Lifeline Program Open
The American Heart Association Mission: Lifeline program objectives are to improve the quality of care and outcomes for patients with ST‐segment–elevation myocardial infarction. Every minute of delay in treatment adversely affects 1‐year m…
View article: Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021
Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 Open
Importance Recognizing the association between timely treatment and less myocardial injury for patients with ST-segment elevation myocardial infarction (STEMI), US national guidelines recommend specific treatment-time goals. Objective To d…
View article: An R-based reproducible and user-friendly preprocessing pipeline for CyTOF data
An R-based reproducible and user-friendly preprocessing pipeline for CyTOF data Open
Mass cytometry (CyTOF) has become a method of choice for in-depth characterization of tissue heterogeneity in health and disease, and is currently implemented in multiple clinical trials, where higher quality standards must be met. Current…
View article: Contents
Contents Open
View article: scROSHI: robust supervised hierarchical identification of single cells
scROSHI: robust supervised hierarchical identification of single cells Open
Identifying cell types based on expression profiles is a pillar of single cell analysis. Existing machine-learning methods identify predictive features from annotated training data, which are often not available in early-stage studies. Thi…
View article: Percutaneous Coronary Intervention With and Without Intravascular Ultrasound for Patients With Complex Lesions: Utilization, Mortality, and Target Vessel Revascularization
Percutaneous Coronary Intervention With and Without Intravascular Ultrasound for Patients With Complex Lesions: Utilization, Mortality, and Target Vessel Revascularization Open
Background: Intravascular ultrasound (IVUS) has several benefits during percutaneous coronary interventions (PCIs), including more accurate vessel sizing, improved stent expansion, and better strut apposition. Prior clinical trials have de…