Keith M. Sullivan
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View article: A retrospective study on beta-blocker use and outcomes in hematopoietic stem cell transplant patients
A retrospective study on beta-blocker use and outcomes in hematopoietic stem cell transplant patients Open
Recent studies have linked beta-blocker (BB) use in critical care settings with improved survival outcomes, potentially due to beta-adrenergic receptor ( β -AR) blockade and associated anti-inflammatory effects. Given the immune system’s r…
View article: Cutaneous dysbiosis characterizes the post–allogeneic hematopoietic stem cell transplantation period
Cutaneous dysbiosis characterizes the post–allogeneic hematopoietic stem cell transplantation period Open
Gut dysbiosis is linked to mortality and the development of graft-versus-host disease after hematopoietic stem cell transplantation (HSCT), but the impact of cutaneous dysbiosis remains unexplored. We performed a pilot observational study,…
View article: Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation for Diffuse Cutaneous Systemic Sclerosis: Identifying Disease Risk Factors for Toxicity and Long‐Term Outcomes in a Prospective, Single‐Arm Trial
Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation for Diffuse Cutaneous Systemic Sclerosis: Identifying Disease Risk Factors for Toxicity and Long‐Term Outcomes in a Prospective, Single‐Arm Trial Open
Objective Two randomized trials for patients with diffuse systemic sclerosis (SSc) demonstrated an overall survival (OS) and event‐free survival (EFS) advantage of autologous hematopoietic stem cell transplantation (AHSCT) using CD34+ sele…
View article: Hematopoietic Cell Transplant compared with Standard Care in Adolescents and Young Adults with Sickle Cell Disease.
Hematopoietic Cell Transplant compared with Standard Care in Adolescents and Young Adults with Sickle Cell Disease. Open
Disease-modifying therapies are standard of care (SOC) for sickle cell disease (SCD), but hematopoietic cell transplantation (HCT) has curative potential. We compared outcomes prospectively through 2-years after biologic assignment to a Do…
View article: Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease
Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease Open
Disease-modifying therapies are standard of care (SOC) for sickle cell disease (SCD), but hematopoietic cell transplantation (HCT) has curative potential. We compared outcomes prospectively through 2 years after biologic assignment to a do…
View article: Myeloablation Followed by Hematopoietic Stem Cell Transplantation and Long‐Term Normalization of Systemic Sclerosis Molecular Signatures
Myeloablation Followed by Hematopoietic Stem Cell Transplantation and Long‐Term Normalization of Systemic Sclerosis Molecular Signatures Open
Objective In the randomized Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial, myeloablation, followed by hematopoietic stem cell transplantation (HSCT), led to the normalization of systemic sclerosis (SSc) peripheral blood cel…
View article: Reflections: A New Monthly Feature in Transplantation and Cellular Therapy
Reflections: A New Monthly Feature in Transplantation and Cellular Therapy Open
View article: Editorial: Stem cell transplantation in autoimmune diseases (AID)
Editorial: Stem cell transplantation in autoimmune diseases (AID) Open
EDITORIAL article Front. Immunol., 01 March 2023Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1150664
View article: Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation
Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation Open
View article: Effects of Cognitive Executive Load on Crashes and Near-Crashes for Young Versus Older Drivers
Effects of Cognitive Executive Load on Crashes and Near-Crashes for Young Versus Older Drivers Open
View article: Safety and efficacy of recombinant and live herpes zoster vaccines for prevention in at-risk adults with chronic diseases and immunocompromising conditions
Safety and efficacy of recombinant and live herpes zoster vaccines for prevention in at-risk adults with chronic diseases and immunocompromising conditions Open
Compared with the general population, older adults with immune senescence and individuals who are immunocompromised (IC) due to disease or immunosuppressive therapy are at increased risk for herpes zoster (HZ) and its associated complicati…
View article: Improving outcomes in scleroderma: recent progress of cell-based therapies
Improving outcomes in scleroderma: recent progress of cell-based therapies Open
Scleroderma is a rare, potentially fatal, clinically heterogeneous, systemic autoimmune connective tissue disorder that is characterized by progressive fibrosis of the skin and visceral organs, vasculopathy and immune dysregulation. The mo…
View article: Enrollment Lessons from a Biological Assignment Study of Marrow Transplantation versus Standard Care for Adolescents and Young Adults with Sickle Cell Disease: Considerations for Future Gene and Cellular Therapy Trials
Enrollment Lessons from a Biological Assignment Study of Marrow Transplantation versus Standard Care for Adolescents and Young Adults with Sickle Cell Disease: Considerations for Future Gene and Cellular Therapy Trials Open
View article: Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis
Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis Open
Together, these findings suggest that myeloablative autologous HSCT resets the IGH repertoire to a more naïve state characterised by IgM-expressing B cells, providing a possible mechanism for the elimination of pathogenic B cells that may …
View article: Adjuvanted recombinant zoster vaccine decreases herpes zoster-associated pain and the use of pain medication across 3 randomized, placebo-controlled trials
Adjuvanted recombinant zoster vaccine decreases herpes zoster-associated pain and the use of pain medication across 3 randomized, placebo-controlled trials Open
Herpes zoster (HZ) and HZ-associated pain greatly affect patients' quality of life, particularly in older and immunocompromised adults, for whom comorbidities and polypharmacy are often reported. Three phase III, randomized, placebo-contro…
View article: Lymphocyte subset abnormalities in early severe scleroderma favor a Th2 phenotype and are not altered by prior immunosuppressive therapy
Lymphocyte subset abnormalities in early severe scleroderma favor a Th2 phenotype and are not altered by prior immunosuppressive therapy Open
Objectives The Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial compared hematopoietic stem cell transplant to CYC treatment in patients with early SSc with progressive skin and lung or kidney involvement. Here we describe lym…
View article: Cognitive impairment in candidates for allogeneic hematopoietic stem cell transplantation
Cognitive impairment in candidates for allogeneic hematopoietic stem cell transplantation Open
View article: Clinical and Molecular Findings After Autologous Stem Cell Transplantation or Cyclophosphamide for Scleroderma: Handling Missing Longitudinal Data
Clinical and Molecular Findings After Autologous Stem Cell Transplantation or Cyclophosphamide for Scleroderma: Handling Missing Longitudinal Data Open
Objective Among individuals with systemic sclerosis (SSc) randomized to cyclophosphamide (CYC) (n = 34) or hematopoietic stem cell transplantation (HSCT) (n = 33), we examined longitudinal trends of clinical, pulmonary function, and qualit…
View article: Adjuvanted recombinant zoster vaccine in adult autologous stem cell transplant recipients: polyfunctional immune responses and lessons for clinical practice
Adjuvanted recombinant zoster vaccine in adult autologous stem cell transplant recipients: polyfunctional immune responses and lessons for clinical practice Open
Immunocompromised individuals, particularly autologous hematopoietic stem cell transplant (auHSCT) recipients, are at high risk for herpes zoster (HZ). We provide an in-depth description of humoral and cell-mediated immune (CMI) responses …
View article: Pulmonary, Gonadal, and Central Nervous System Status after Bone Marrow Transplantation for Sickle Cell Disease
Pulmonary, Gonadal, and Central Nervous System Status after Bone Marrow Transplantation for Sickle Cell Disease Open
We conducted a prospective, multicenter investigation of human-leukocyte antigen (HLA) identical sibling bone marrow transplantation (BMT) in children with severe sickle cell disease (SCD) between 1991 and 2000. To determine if children we…
View article: Re-evaluating inclusion criteria for autologous hematopoietic stem cell transplantation in advanced systemic sclerosis: Three successful cases and review of the literature
Re-evaluating inclusion criteria for autologous hematopoietic stem cell transplantation in advanced systemic sclerosis: Three successful cases and review of the literature Open
Systemic sclerosis is a chronic autoimmune disease with a poor prognosis, particularly when a patient has rapidly progressive skin or pulmonary involvement. Autologous hematopoietic stem cell transplant is an emerging treatment for this co…
View article: Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes
Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes Open
Background: Evidence about the impact of marital status before hematopoietic cell transplantation (hct) on outcomes after hct is conflicting. Methods: We identified patients 40 years of age and older within the Center for International Blo…
View article: Large‐Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis
Large‐Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis Open
Objective To provide a large‐scale assessment of serum protein dysregulation in diffuse cutaneous systemic sclerosis (dcSSc) and to investigate serum protein correlates of SSc fibrotic features. Methods We investigated serum protein profil…
View article: 7. Can Recombinant Zoster Vaccine Administration Decrease the Use of Herpes Zoster-related Pain Medication Across Randomized Controlled Studies?
7. Can Recombinant Zoster Vaccine Administration Decrease the Use of Herpes Zoster-related Pain Medication Across Randomized Controlled Studies? Open
Background Older and immunocompromised adults are at increased risk for herpes zoster (HZ) and often experience persistent, severe HZ-related pain, impacting their quality of life and activities of daily living. High vaccine efficacy (VE) …
View article: Clinical and Neuroimaging Correlates of Post-Transplant Delirium
Clinical and Neuroimaging Correlates of Post-Transplant Delirium Open
Delirium is common among adults undergoing hematopoietic stem cell transplantation (HCT), although the clinical and neuroimaging correlates of post-HCT delirium have not been adequately delineated. We therefore examined the frequency of de…
View article: Machine learning predicts stem cell transplant response in severe scleroderma
Machine learning predicts stem cell transplant response in severe scleroderma Open
View article: Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality
Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality Open
Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that …
View article: Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial
Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial Open
View article: Phase I dose escalation study of naive T-cell depleted donor lymphocyte infusion following allogeneic stem cell transplantation
Phase I dose escalation study of naive T-cell depleted donor lymphocyte infusion following allogeneic stem cell transplantation Open
View article: Data from: Quantifying skin stiffness in graft-versus-host disease, morphea and systemic sclerosis using acoustic radiation force impulse imaging and shear wave elastography
Data from: Quantifying skin stiffness in graft-versus-host disease, morphea and systemic sclerosis using acoustic radiation force impulse imaging and shear wave elastography Open
There is a need for objective, sensitive and reproducible methods of assessing skin sclerosis. We performed a cross sectional, non-interventional study to evaluate the utility of accoustic radiation force impulse (ARFI) and shear wave elas…