Explanipedia

Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets Open

Nina Derby, Bryan A. Johnson, Sreya Biswas, Miranda Fischer, Katherine A. Fancher , et al. · 2025

Liver dysfunction is more common and more severe among people with HIV than in the general population. Our previous transcriptomic analysis identified an increased hepatic type-1 interferon (IFN-1) response in simian immunodeficiency virus…

Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets Open

Nina Derby, Bryan A. Johnson, Sreya Biswas, Miranda Fischer, Katherine A. Fancher , et al. · 2025

Liver dysfunction is more common and more severe among people with HIV than in the general population. Our previous transcriptomic analysis identified an increased hepatic type-1 interferon (IFN-1) response in simian immunodeficiency virus…

The Role of Serum Albumin and Secretory Phospholipase A2 in Sepsis Open

Francis H.C. Tsao, Zhanhai Li, Amy Amessoudji, Dunia Jawdat, Musharaf Sadat , et al. · 2024

Sepsis is caused by a dysregulated host response to an infection that leads to cascading cell death and eventually organ failure. In this study, the role of inflammatory response serum secretory phospholipase A2 (sPLA2) and albumin in seps…

Human Serum Albumin Misfolding in Aging and Disease Open

Francis H.C. Tsao, Keith C. Meyer · 2022

Age-dependent conformational stability of human serum albumin was determined by the method of fluorescent bilayer liposome assay. After pre-heating at 80 °C, albumin in the sera of 74-year-old healthy subjects exhibited hydrophobic effects…

Long-term evaluation of the safety and efficacy of recombinant human pentraxin-2 (rhPTX-2) in patients with idiopathic pulmonary fibrosis (IPF): an open-label extension study Open

Ganesh Raghu, Mark J. Hamblin, Alison Brown, Jeffrey A. Golden, Lawrence Ho , et al. · 2022

Cryptogenic organising pneumonia: current understanding of an enigmatic lung disease Open

Ganesh Raghu, Keith C. Meyer · 2021

Organising pneumonia (OP) is currently recognised as a nonspecific lung injury response that is associated with a variety of imaging patterns obtained with high-resolution computed tomography (HRCT) of the chest and is characterised histop…

Optimizing virus protection in lung transplant recipients: Don’t drop the ball Open

Keith C. Meyer, Robin K. Avery · 2021

Meyer and Avery comment on the implications of a study by Hostetler et al. (page 2864), in which screening of a large group of lung transplant candidates revealed that some lacked humoral immunity to measles, mumps, and varicella, especial…

Acute exacerbations of interstitial lung disease: what is the best treatment? Open

Keith C. Meyer · 2021

Risks of lung transplantation in the SARS-CoV-2 era Open

Keith C. Meyer · 2020

Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients Open

Dieter Worlitzsch, Robert Tarran, Martina Ulrich, Ute Schwab, Aynur Cekici , et al. · 2020

Current theories of CF pathogenesis predict different predisposing “local environmental” conditions and sites of bacterial infection within CF airways. Here we show that, in CF patients with established lung disease, Psuedomonas aeruginosa…

Aging-Related and Gender Specific Albumin Misfolding in Alzheimer’s Disease Open

Francis H.C. Tsao, Jill N. Barnes, Amy Amessoudji, Zhanhai Li, Keith C. Meyer · 2020

Aging-related protein misfolding and aggregation may play critical roles in the pathogenesis of numerous diseases. In the brain, extracellular aggregated amyloid-β (Aβ) is closely related to the death of neurons in individuals with Alzheim…

Treatment of primary sjögren's syndrome-related interstitial lung disease: a retrospective cohort study. Open

Barkha Amlani, Ghada M. El‐Sayed, Umang Barvalia, Jeffrey P. Kanne, Keith C. Meyer , et al. · 2020

Mycophenolate treatment was associated with significant improvement in PFTs of pSS-ILD patients over time, and azathioprine treatment followed a similar non-significanttrend. Additional prospective studies are needed to further evaluate th…

Therapeutic Approach to Chronic Venous Insufficiency - Clinical Benefits of Red-Vine-Leaf-Extract AS 195 (Antistax) Open

Markus Stücker, Eberhard Rabe, Keith C. Meyer, Bertram Ottillinger, Tanja Schütt · 2019

P3‐078: AGING‐RELATED PROTEIN MISFOLDING AND NEURODEGENERATIVE DISEASES Open

Francis H.C. Tsao, Keith C. Meyer, Jill N. Barnes, Amy Amessoudji, Zhanhai Li · 2019

Aging-related misfolded proteins appear to play critical roles in neurodegenerative diseases including Alzheimer's disease (AD). A fluorescent liposome assay was used to determine whether differences in the binding activity of albumin with…

High Lung Allocation Scores and Lung Transplantation Open

Keith C. Meyer · 2019

Lactic acid concentrations in bronchoalveolar lavage fluid correlate with neutrophil influx in cystic fibrosis Open

Keith C. Meyer, Amy Amessoudji, Trina Hollatz, Francis HS Tsao · 2019

Balancing fairness and efficacy in lung allocation for transplantation: unfinished business Open

Keith C. Meyer · 2018

While the field of lung transplantation has evolved considerably since the first lung transplant with long-term success was performed in 1983,1 the need for donated lungs to help patients with progressive end-stage lung diseases that do no…

Mycophenolate therapy in interstitial pneumonia with autoimmune features: a cohort study Open

Sara S. McCoy, Zubin Mukadam, Keith C. Meyer, Jeffrey P. Kanne, Cristopher A. Meyer , et al. · 2018

Patients with IPAF might benefit from mycophenolate therapy. Larger prospective clinical trials are needed to evaluate the efficacy of mycophenolate for patients who meet criteria for IPAF.

Recent advances in lung transplantation Open

Keith C. Meyer · 2018

Lung transplantation can improve quality of life and prolong survival for individuals with end-stage lung disease, and many advances in the realms of both basic science and clinical research aspects of lung transplantation have emerged ove…

Faculty Opinions recommendation of Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury. Open

Keith C. Meyer · 2018

Primary graft dysfunction (PGD) is acute lung injury within 72 hours of lung transplantation. We hypothesized that cell-free hemoglobin (CFH) contributes to PGD by increasing lung microvascular permeability and tested this in patients, ex …

Faculty Opinions recommendation of Mesenchymal Stromal Cell Therapy for Chronic Lung Allograft Dysfunction: Results of a First-in-Man Study. Open

Keith C. Meyer · 2018

Chronic lung transplant rejection (termed chronic lung allograft dysfunction [CLAD]) is the main impediment to long-term survival after lung transplantation. Bone marrow-derived mesenchymal stromal cells (MSCs) represent an attractive cell…

Faculty Opinions recommendation of Expanding the donor lung pool: how many donations after circulatory death organs are we missing? Open

Keith C. Meyer · 2018

BACKGROUND: The number of patients with end-stage pulmonary disease awaiting lung transplantation is at an all-time high, while the supply of available organs remains stagnant. Utilizing donation after circulatory death (DCD) donors may he…

Faculty Opinions recommendation of Ambulatory veno-venous extracorporeal membrane oxygenation. Open

Keith C. Meyer · 2018

Veno-venous extracorporeal membrane oxygenation (VV ECMO) is used for support in patients with severe respiratory failure. The method allows extracorporeal gas exchange and may replace the patient's lung function for weeks and even years. …

Bidirectional transfer of Anelloviridae lineages between graft and host during lung transplantation Open

Arwa Abbas, Jacque C. Young, Erik Clarke, Joshua M. Diamond, Ize Imai , et al. · 2018

Effect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis Open

Ganesh Raghu, Bernt van den Blink, Mark J. Hamblin, Alison Brown, Jeffrey A. Golden , et al. · 2018

clinicaltrials.gov Identifier: NCT02550873.

Specific Donor HLA-DR Types Correlate With Altered Susceptibility to Development of Chronic Lung Allograft Dysfunction Open

Lynn D. Haynes, Walker Julliard, Joshua D. Mezrich, Glen Leverson, Keith C. Meyer , et al. · 2018

We show in this retrospective study that specific donor HLA class II types are important in lung transplantation, because they are associated with either protection from or susceptibility to development of severe BOS.

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations Open

Denis Hadjiliadis, Alexander Khoruts, Ann G. Zauber, Sarah E. Hempstead, Patrick Maisonneuve , et al. · 2017

Identification of Diagnostic Criteria for Chronic Hypersensitivity Pneumonitis. An International Modified Delphi Survey Open

Julie Morisset, Kerri A. Johannson, Kirk D. Jones, Paul J. Wolters, Harold R. Collard , et al. · 2017

This consensus-based approach for the diagnosis of cHP represents a first step towards the development of international guidelines for the diagnosis of cHP.

Pleuroparenchymal fibroelastosis associated with telomerase reverse transcriptase mutations Open

Chad A. Newton, Kiran Batra, José Torrealba, Keith C. Meyer, Ganesh Raghu , et al. · 2017

We thank H. Nunes and colleagues for their interest in our study of patients with telomere-related gene mutations associated with pleuroparenchymal fibroelastosis (PPFE) [1]. Their cohort of five patients with PPFE and rare variants in tel…

Role of pirfenidone in the management of pulmonary fibrosis Open

Keith C. Meyer, Catherine F. Decker · 2017

Pulmonary fibrosis is associated with a number of specific forms of interstitial lung disease (ILD) and can lead to progressive decline in lung function, poor quality of life, and, ultimately, early death. Idiopathic pulmonary fibrosis (IP…

Keith C. Meyer YOU? Author Swipe