Keith J. Page
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View article: NETSseq unveils deep molecular insights into astrocyte function in Alzheimer's disease in the human brain
NETSseq unveils deep molecular insights into astrocyte function in Alzheimer's disease in the human brain Open
Background Sporadic Alzheimer's disease (AD) is a complex and heterogenous condition, posing challenges for the development of effective therapeutics. A detailed molecular understanding of how specific brain cell types change throughout di…
View article: NETSseq reveals inflammatory and aging mechanisms in distinct cell types, driving cerebellar decline in ataxia telangiectasia
NETSseq reveals inflammatory and aging mechanisms in distinct cell types, driving cerebellar decline in ataxia telangiectasia Open
Ataxia–telangiectasia (A–T) is a rare, autosomal recessive, multisystem disorder caused by mutations in the Ataxia–Telangiectasia Mutated (ATM) gene and is characterized by a devastating and progressive neurological pathology. The cellular…
View article: NETSseq Reveals Inflammatory and Aging Mechanisms in Distinct Cell Types Driving Cerebellar Decline in Ataxia Telangiectasia
NETSseq Reveals Inflammatory and Aging Mechanisms in Distinct Cell Types Driving Cerebellar Decline in Ataxia Telangiectasia Open
Summary The cellular and molecular changes driving the neurological abnormalities associated with ataxia – telangiectasia (A-T) are not well understood. Here, we applied our proprietary Nuclear Enriched Transcript Sort sequencing (NETSseq)…
View article: Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management
Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management Open
Obesity emerges from a complex interplay of factors, including imbalanced interoception, genetic predisposition, and environmental cues, ultimately disrupting body weight homeostasis 1 . While much research has concentrated on strategies t…
View article: NETS‐seq advances the understanding of neuronal vulnerability in AD progression facilitating the identification of novel therapeutic targets at the single cell type level
NETS‐seq advances the understanding of neuronal vulnerability in AD progression facilitating the identification of novel therapeutic targets at the single cell type level Open
Background Alzheimer’s Disease (AD) is a complex, heterogeneous, and multi‐factorial disease of predominantly the aging population. Throughout disease progression, different brain regions and cell types within each region show varying leve…
View article: CCDC 2283232: Experimental Crystal Structure Determination
CCDC 2283232: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses Open
Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting molecule MR1. The extent of MAIT TCR crossreactivity toward ph…
View article: Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome
Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome Open
Neuroinflammation, specifically the NLRP3 inflammasome cascade, is a common underlying pathological feature of many neurodegenerative diseases. Evidence suggests that NLRP3 activation involves changes in intracellular K+. Nuclear Enriched …
View article: The selective 5‐HT<sub>1F</sub> receptor agonist lasmiditan inhibits trigeminal nociceptive processing: Implications for migraine and cluster headache
The selective 5‐HT<sub>1F</sub> receptor agonist lasmiditan inhibits trigeminal nociceptive processing: Implications for migraine and cluster headache Open
Background and Purpose Lasmiditan is a novel selective 5‐HT 1F receptor agonist, recently approved for acute treatment of migraine. 5‐HT 1F receptors are widely expressed in the CNS and trigeminovascular system. Here, we have explored the …
View article: Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors Open
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T c…
View article: Link between aged care home staff dementia knowledge and experiences caring for people with dementia
Link between aged care home staff dementia knowledge and experiences caring for people with dementia Open
Working with people living with dementia in residential aged care can be challenging, which is exacerbated by low levels of dementia knowledge. This study investigated the relationship between aged care home staff knowledge of dementia and…