Keith R. Pennypacker
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View article: Expression of dementia biomarkers in Appalachian and non-Appalachian ELVO patients during thrombectomy
Expression of dementia biomarkers in Appalachian and non-Appalachian ELVO patients during thrombectomy Open
Background/Context Vascular Cognitive Impairment and Dementia (VCID) affects 25-30% of stroke patients and includes cognitive impairments caused by vascular injury, such as post-stroke dementia. Rehabilitation has the potential to improve …
View article: Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement
Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement Open
Background Acute hyperglycemia affects approximately 40% of stroke patients and is associated with worse outcomes. The underlying mechanisms linking this metabolic stress to stroke-induced brain injury remains unclear, and effective therap…
View article: Sex- and Tissue-Specific Effects of Leukemia Inhibitory Factor on Mitochondrial Bioenergetics Following Ischemic Stroke
Sex- and Tissue-Specific Effects of Leukemia Inhibitory Factor on Mitochondrial Bioenergetics Following Ischemic Stroke Open
Oxidative stress due to increased reactive oxygen species (ROS) formation and/or inflammation is considered to play an important role in ischemic stroke injury. Leukemia inhibitory factor (LIF) has been shown to protect both oligodendrocyt…
View article: Proteomic and Demographic Comparisons of Recurrent Ischemic Stroke Patients
Proteomic and Demographic Comparisons of Recurrent Ischemic Stroke Patients Open
Rates of recurrent strokes have remained relatively unchanged over the past couple decades, highlighting a need for advancements in secondary prevention of stroke recurrence. This study utilizes the Blood And Clot Thrombectomy Registry And…
View article: Methodology of INDICATE: Investigating Neuromarkers for Decline & Impairment of Cognition After Thrombectomy for ELVO
Methodology of INDICATE: Investigating Neuromarkers for Decline & Impairment of Cognition After Thrombectomy for ELVO Open
Background Vascular cognitive impairment and dementia (VCID) is present in 25‐30% of stroke patients, and a need exists to develop predictive biomarkers to identify patients that will incur chronic cognitive impairment. The National Plan t…
View article: Regenerating Family Member 3 Alpha Is Predictive of Mortality Following Emergent Large Vessel Occlusion
Regenerating Family Member 3 Alpha Is Predictive of Mortality Following Emergent Large Vessel Occlusion Open
Regenerating Family Member 3 Alpha (REG3A) is an antimicrobial protein secreted by the intestine and pancreas with additional immunomodulatory properties. Previously, we published that REG3A expression in ischemic stroke patient systemic b…
View article: The differential proteomic response to ischemic stroke in appalachian subjects treated with mechanical thrombectomy
The differential proteomic response to ischemic stroke in appalachian subjects treated with mechanical thrombectomy Open
Our study utilizes an ELVO tissue bank and registry to investigate the intracranial/intravascular proteomic environment occurring at the time of thrombectomy. We found that patients presenting from Appalachian areas have different levels o…
View article: CCR3 Expression in Relation to Delayed Microbleeds in a Rat Model of Large Vessel Occlusion
CCR3 Expression in Relation to Delayed Microbleeds in a Rat Model of Large Vessel Occlusion Open
Thirty percent of ischemic stroke patients develop vascular cognitive impairment and dementia (VCID) within 1 year of stroke onset. The expression of C-C motif chemokine receptor 3 (CCR3) is associated with endothelial dysfunction and memo…
View article: P-026 Extracellular vesicle neurotrophin expression in plasma collected during mechanical thrombectomy from patients with emergent large vessel stroke
P-026 Extracellular vesicle neurotrophin expression in plasma collected during mechanical thrombectomy from patients with emergent large vessel stroke Open
Introduction Mechanical thrombectomy (MT) and tissue plasminogen activator are ischemic stroke treatments that assist in restoring blood flow to the brain tissue, but do not guarantee good outcomes. Detection of cellular alterations system…
View article: O-012 Relationship between clot composition and procedural results for ischemic stroke aspiration thrombectomy: subset analysis from the INSIGHT registry
O-012 Relationship between clot composition and procedural results for ischemic stroke aspiration thrombectomy: subset analysis from the INSIGHT registry Open
Introduction The INSIGHT registry is a prospective multicenter registry to collect and analyze clot and blood retrieved during aspiration thrombectomy or hematoma evacuation. This registry will examine whether clot composition and genetic …
View article: Inflammatory-associated proteomic predictors of cognitive outcome in subjects with ELVO treated by mechanical thrombectomy
Inflammatory-associated proteomic predictors of cognitive outcome in subjects with ELVO treated by mechanical thrombectomy Open
Background Emergent Large Vessel Occlusion (ELVO) stroke causes devastating vascular events which can lead to significant cognitive decline and dementia. In the subset of ELVO subjects treated with mechanical thrombectomy (MT) at our insti…
View article: Now that the door is open: an update on ischemic stroke pharmacotherapeutics for the neurointerventionalist
Now that the door is open: an update on ischemic stroke pharmacotherapeutics for the neurointerventionalist Open
The last 10 years have seen a major shift in management of large vessel ischemic stroke with changes towards ever-expanding use of reperfusion therapies (intravenous thrombolysis and mechanical thrombectomy). These strategies ‘open the doo…
View article: Editorial: Biomarkers for stroke recovery
Editorial: Biomarkers for stroke recovery Open
EDITORIAL article Front. Neurol., 07 March 2023Sec. Neurological Biomarkers Volume 14 - 2023 | https://doi.org/10.3389/fneur.2023.1170308
View article: Abstract Number ‐ 25: Acute Ischemic Stroke Intervention With Penumbra RED Reperfusion Catheters: Updated Subset Analysis From INSIGHT Registry
Abstract Number ‐ 25: Acute Ischemic Stroke Intervention With Penumbra RED Reperfusion Catheters: Updated Subset Analysis From INSIGHT Registry Open
Introduction The prospective INSIGHT Registry is a multicenter ‘multi‐omic’ analysis of thrombi associated with acute hemorrhagic or ischemic stroke. This updated interim analysis evaluated the performance of Penumbra RED catheters used du…
View article: Gut microbial dysbiosis correlates with stroke severity markers in aged rats
Gut microbial dysbiosis correlates with stroke severity markers in aged rats Open
Background An imbalanced gut microbial community, or dysbiosis, has been shown to occur following stroke. It is possible that this dysbiosis negatively impacts stroke recovery and rehabilitation. Species level resolution measurements of th…
View article: Functional recovery outcomes following acute stroke is associated with abundance of gut microbiota related to inflammation, butyrate and secondary bile acid
Functional recovery outcomes following acute stroke is associated with abundance of gut microbiota related to inflammation, butyrate and secondary bile acid Open
Accumulating evidence suggests that gut microbes modulate brain plasticity via the bidirectional gut-brain axis and play a role in stroke rehabilitation. However, the microbial species alterations associated with stroke and their correlati…
View article: O-015 What can systemic and intracranial proteomic profiles tell us about why some TICI 3 patients do better than others?
O-015 What can systemic and intracranial proteomic profiles tell us about why some TICI 3 patients do better than others? Open
Introduction In 2003, Higashida et al. proposed the Thrombolysis in Cerebral Infarction (TICI) scale to standardize grading of angiographic outcomes after ischemic stroke intervention. Grades 0–3 represent a spectrum from no perfusion to c…
View article: Influence of BMI on adenosine deaminase and stroke outcomes in mechanical thrombectomy subjects
Influence of BMI on adenosine deaminase and stroke outcomes in mechanical thrombectomy subjects Open
View article: Short Chain Fatty Acids Taken at Time of Thrombectomy in Acute Ischemic Stroke Patients Are Independent of Stroke Severity But Associated With Inflammatory Markers and Worse Symptoms at Discharge
Short Chain Fatty Acids Taken at Time of Thrombectomy in Acute Ischemic Stroke Patients Are Independent of Stroke Severity But Associated With Inflammatory Markers and Worse Symptoms at Discharge Open
Introduction Short chain fatty acids (SCFA) are gut microbiota-derived metabolites that contribute to the gut-brain axis and may impact stroke outcomes following gut dysbiosis. We evaluated plasma SCFA concentrations against stroke severit…
View article: Gut Microbial Dysbiosis is Correlated with Stroke Severity Markers in Aged Rats Following Stroke
Gut Microbial Dysbiosis is Correlated with Stroke Severity Markers in Aged Rats Following Stroke Open
Background: An imbalanced gut microbial community, or dysbiosis, has been shown to occur following stroke. It is possible that this dysbiosis negatively impacts stroke recovery and rehabilitation. Species level resolution measurements of t…
View article: Abstract 1122‐000220: Analysis of Protein Network to Predict Cognition Among Emergent Large Vessel Occlusion Undergoing Mechanical Thrombectomy
Abstract 1122‐000220: Analysis of Protein Network to Predict Cognition Among Emergent Large Vessel Occlusion Undergoing Mechanical Thrombectomy Open
This meeting abstract was removed due to the OA licensing requirements of this journal. The full abstract is listed here : https://www.svin.org/files/SVIN_2021_Abstracts_for_Web.pdf
View article: Abstract 1122‐000102: Function of Proteins Predictive of Infarct Volume in Mechanical Thrombectomy Subjects
Abstract 1122‐000102: Function of Proteins Predictive of Infarct Volume in Mechanical Thrombectomy Subjects Open
This meeting abstract was removed due to the OA licensing requirements of this journal. The full abstract is listed here : https://www.svin.org/files/SVIN_2021_Abstracts_for_Web.pdf
View article: Abstract 1122‐000211: Histology Profiles of Thrombi in Men and Women Undergoing Thrombectomy
Abstract 1122‐000211: Histology Profiles of Thrombi in Men and Women Undergoing Thrombectomy Open
This meeting abstract was removed due to the OA licensing requirements of this journal. The full abstract is listed here : https://www.svin.org/files/SVIN_2021_Abstracts_for_Web.pdf
View article: Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes
Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes Open
Regenerating Family Member 3 Alpha (REG3A) is a multifunctional protein with antimicrobial activity, and primarily secreted by the intestine and pancreas. Studies have shown an increased expression of REG3A in systemic inflammatory respons…
View article: Extended Middle Cerebral Artery Occlusion (MCAO) Model to Mirror Stroke Patients Undergoing Thrombectomy
Extended Middle Cerebral Artery Occlusion (MCAO) Model to Mirror Stroke Patients Undergoing Thrombectomy Open
View article: E-136 Effect of infracted brain area fragmentation on patient outcome
E-136 Effect of infracted brain area fragmentation on patient outcome Open
Purpose Stroke is the 5th leading cause of death in the US. 87% of strokes are ischemic in nature caused by large vessel occlusion. It is established in the literature that the infarct volume directly relates to patient's outcome. We aim t…
View article: E-105 Analysis of clinical associations of serum SCFAs taken at the time of thrombectomy in AIS patients
E-105 Analysis of clinical associations of serum SCFAs taken at the time of thrombectomy in AIS patients Open
Introduction Gut dysbiosis has become a well-recognized process that occurs following stroke, which may provide clinically relevant implications in stroke severity and patient outcome. Short chain fatty acids (SCFAs) are gut microbiota-der…
View article: Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy
Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy Open
Using standard techniques during mechanical thrombectomy, the Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC) protocol (NCT03153683) isolates intracranial arterial blood distal to the thrombus and proximal systemic blood i…
View article: Smoking-Induced Sex Differences in Clinical Outcomes in Patients Undergoing Mechanical Thrombectomy for Stroke
Smoking-Induced Sex Differences in Clinical Outcomes in Patients Undergoing Mechanical Thrombectomy for Stroke Open
These findings are valuable for patient counseling, particularly for women, for smoking cessation.
View article: Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity
Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity Open
Background Emergent large vessel occlusion (ELVO) strokes are devastating ischemic vascular events for which novel treatment options are needed. Using vascular cell adhesion molecule 1 (VCAM1) as a prototype, the objective of this study wa…