Keith Robison
YOU?
Author Swipe
Bayesian phylogenetics on globally emerging SARS-CoV-2 variant BA.2.86 suggest global distribution and rapid evolution Open
Using bioinformatic pipelines and Bayseian phylogenetic analyses, we characterized a SARS-CoV-2 variant designated by the World Health Organization as a variant under monitoring in August 2023. Here we analyze the genomes of this SARS-CoV-…
Computational Elucidation of Protein-Protein Interactions in the Minimal Proteome of JCVI-syn3A Open
Proteins play a vital role in the regulation of biological processes, facilitating the transfer of intermediates and coordinating the sequential steps of biochemical pathways. Protein-protein interactions (PPIs) are crucial molecular event…
View article: 1525. The Impact of Traveler-Based Genomic Surveillance on SARS-CoV-2 Variant Detection in Arriving International Air Travelers– United States, November 29, 2021-April 24, 2022
1525. The Impact of Traveler-Based Genomic Surveillance on SARS-CoV-2 Variant Detection in Arriving International Air Travelers– United States, November 29, 2021-April 24, 2022 Open
Background International travel facilitates SARS-CoV-2 spread globally. Early detection of variants among arriving international travelers could provide viral information about introduction of variants with differing infectivity, virulence…
242 Development of pooled screening platform for discovering the next generation chimeric antigen receptors Open
Background Signaling cascades triggered by intracellular domains (ICDs) of Chimeric Antigen Receptor (CAR) in immune cells drive cell behaviors that correspond to different therapeutic outcomes. While canonical CAR-T ICD combinations 4-1BB…
View article: Early Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Variants Using Traveler-based Genomic Surveillance at 4 US Airports, September 2021–January 2022
Early Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Variants Using Traveler-based Genomic Surveillance at 4 US Airports, September 2021–January 2022 Open
We enrolled arriving international air travelers in a severe acute respiratory syndrome coronavirus 2 genomic surveillance program. We used molecular testing of pooled nasal swabs and sequenced positive samples for sublineage. Traveler-bas…
View article: Early detection of SARS-CoV-2 variants using traveler-based genomic surveillance at four US airports, September 2021- January 2022
Early detection of SARS-CoV-2 variants using traveler-based genomic surveillance at four US airports, September 2021- January 2022 Open
We enrolled arriving international air travelers in SARS-CoV-2 genomic surveillance, using molecular testing of pooled nasal swabs, and sequencing positive samples for viral lineage. Traveler-based genomic surveillance provided early warni…
View article: Variant abundance estimation for SARS-CoV-2 in wastewater using RNA-Seq quantification
Variant abundance estimation for SARS-CoV-2 in wastewater using RNA-Seq quantification Open
Effectively monitoring the spread of SARS-CoV-2 variants is essential to efforts to counter the ongoing pandemic. Wastewater monitoring of SARS-CoV-2 RNA has proven an effective and efficient technique to approximate COVID-19 case rates in…
View article: Simulated wastewater sequencing data for benchmarking SARS-CoV-2 variant abundance estimation
Simulated wastewater sequencing data for benchmarking SARS-CoV-2 variant abundance estimation Open
To evaluate the accuracy of variant abundance predictions from wastewater sequencing, we built a collection of benchmarking datasets that resemble real wastewater samples. For each variant (B.1.1.7, B.1.351, B.1.427, B.1.429, P.1) we creat…
View article: Simulated wastewater sequencing data for benchmarking SARS-CoV-2 variant abundance estimation
Simulated wastewater sequencing data for benchmarking SARS-CoV-2 variant abundance estimation Open
To evaluate the accuracy of variant abundance predictions from wastewater sequencing, we built a collection of benchmarking datasets that resemble real wastewater samples. For each variant (B.1.1.7, B.1.351, B.1.427, B.1.429, P.1) we creat…
View article: Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface Open
Significance This manuscript reports on a member of the FK506/rapamycin family, WDB002, and the realization that FKBP-mediated recognition is a genetically programmable modality that enables engagement of topologically flat targets. FKBP-m…