Keith Starnes
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View article: Ictal emotional features in pediatric and young adult patients with frontal lobe epilepsy
Ictal emotional features in pediatric and young adult patients with frontal lobe epilepsy Open
Objective To assess the localization and lateralization values of ictal emotional features and ictal defensive behaviors in pediatric and young adult patients with frontal lobe epilepsy (FLE). Methods Children and young adults with FLE wer…
View article: Optimizing stimulation parameters for anterior thalamic nuclei deep brain stimulation in epilepsy: A randomized crossover trial
Optimizing stimulation parameters for anterior thalamic nuclei deep brain stimulation in epilepsy: A randomized crossover trial Open
Objective The effects of brain stimulation for diseases like epilepsy are delayed, making stimulation optimization difficult. The parameters for anterior thalamic nuclei (ANT) deep brain stimulation (DBS) for focal drug‐resistant epilepsy …
View article: Noninvasive brain stimulation as focal epilepsy treatment in the hospital, clinic, and home
Noninvasive brain stimulation as focal epilepsy treatment in the hospital, clinic, and home Open
Objective Noninvasive brain stimulation (NIBS) provides a treatment option for patients not eligible for surgical intervention or who seek low‐risk approaches and may be used in the hospital, clinic, and at home. Our objective is to summar…
View article: Intracranial stimulation for pediatric refractory epilepsy: A single institutional experience using evolving therapies
Intracranial stimulation for pediatric refractory epilepsy: A single institutional experience using evolving therapies Open
Objective Neuromodulation for pediatric refractory epilepsy (PRE) is preferred when the seizure onset zone is not amenable to surgical resection, due to multifocal onset or involvement of eloquent cortex. Given its rapidly evolving landsca…
View article: Noninvasive Brain Stimulation as Focal Epilepsy Treatment in the Hospital, Clinic, and Home
Noninvasive Brain Stimulation as Focal Epilepsy Treatment in the Hospital, Clinic, and Home Open
Introduction Noninvasive brain stimulation (NIBS) provides a treatment option for patients not eligible for surgical intervention or who seek low-risk approaches and may be used in the hospital, clinic and at home. Our objective is to summ…
View article: Optimizing stimulation parameters for anterior thalamic nuclei deep brain stimulation in epilepsy: A randomized cross-over trial
Optimizing stimulation parameters for anterior thalamic nuclei deep brain stimulation in epilepsy: A randomized cross-over trial Open
Objective The effects of brain stimulation for diseases like epilepsy are delayed, making stimulation optimization difficult. The parameters for anterior thalamic nuclei (ANT) deep brain stimulation (DBS) for focal drug-resistant epilepsy …
View article: Thalamocortical network neuromodulation for epilepsy
Thalamocortical network neuromodulation for epilepsy Open
Despite the growing interest in network-guided neuromodulation for epilepsy, uncertainty about the safety and long-term efficacy of thalamocortical stimulation persists. Our evaluation focused on the use of a four-lead open-loop implantabl…
View article: Centromedian thalamic deep brain stimulation for idiopathic generalized epilepsy – case series and target analysis
Centromedian thalamic deep brain stimulation for idiopathic generalized epilepsy – case series and target analysis Open
Introduction There is a lack of treatment options for individuals with drug resistant idiopathic generalized epilepsy (IGE). Small, limited case series suggest that centromedian thalamus deep brain stimulation (CM-DBS) may be an effective …
View article: Thalamocortical network neuromodulation for epilepsy
Thalamocortical network neuromodulation for epilepsy Open
Objectives Despite the growing interest in network-guided neuromodulation for epilepsy, uncertainty about the safety and long-term efficacy of thalamocortical stimulation persist. Our evaluation focused on the use of a 4-lead open-loop imp…
View article: Emerging approaches in neurostimulation for epilepsy
Emerging approaches in neurostimulation for epilepsy Open
Purpose of review Neurostimulation is a quickly growing treatment approach for epilepsy patients. We summarize recent approaches to provide a perspective on the future of neurostimulation. Recent findings Invasive stimulation for treatment…
View article: Responsive neurostimulation with low‐frequency stimulation
Responsive neurostimulation with low‐frequency stimulation Open
Deep brain stimulation and responsive neurostimulation (RNS) use high‐frequency stimulation (HFS) per the pivotal trials and manufacturer‐recommended therapy protocols. However, not all patients respond to HFS. In this retrospective case s…
View article: Neurodevelopmental and Epilepsy Phenotypes in Individuals With Missense Variants in the Voltage-Sensing and Pore Domains of <i>KCNH5</i>
Neurodevelopmental and Epilepsy Phenotypes in Individuals With Missense Variants in the Voltage-Sensing and Pore Domains of <i>KCNH5</i> Open
We describe a cohort of 17 individuals with pathogenic or likely pathogenic missense variants in the voltage-sensing and pore domains of Kv10.2, including 14 previously unreported individuals. We present evidence for a putative emerging ge…
View article: Case Report: Prolonged Effects of Short-Term Transcranial Magnetic Stimulation on EEG Biomarkers, Spectral Power, and Seizure Frequency
Case Report: Prolonged Effects of Short-Term Transcranial Magnetic Stimulation on EEG Biomarkers, Spectral Power, and Seizure Frequency Open
Transcranial magnetic stimulation (TMS) is a non-invasive modality of focal brain stimulation in which a fluctuating magnetic field induces electrical currents within the cortex. It remains unclear to what extent TMS alters EEG biomarkers …
View article: Centromedian Nucleus of the Thalamus Deep Brain Stimulation for Genetic Generalized Epilepsy: A Case Report and Review of Literature
Centromedian Nucleus of the Thalamus Deep Brain Stimulation for Genetic Generalized Epilepsy: A Case Report and Review of Literature Open
There is a paucity of treatment options for cognitively normal individuals with drug resistant genetic generalized epilepsy (GGE). Centromedian nucleus of the thalamus (CM) deep brain stimulation (DBS) may be a viable treatment for GGE. He…
View article: Missense variants in the voltage sensing and pore domain of <i>KCNH5</i> cause neurodevelopmental phenotypes including epilepsy
Missense variants in the voltage sensing and pore domain of <i>KCNH5</i> cause neurodevelopmental phenotypes including epilepsy Open
Objective KCNH5 encodes the voltage-gated potassium channel EAG2/Kv10.2. We aimed to delineate the neurodevelopmental and epilepsy phenotypic spectrum associated with de novo KCNH5 variants. Methods We screened 893 individuals with develop…
View article: A Review of Neurostimulation for Epilepsy in Pediatrics
A Review of Neurostimulation for Epilepsy in Pediatrics Open
Neurostimulation for epilepsy refers to the application of electricity to affect the central nervous system, with the goal of reducing seizure frequency and severity. We review the available evidence for the use of neurostimulation to trea…