Keith Woodley
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View article: Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation
Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation Open
View article: SCD inhibition preferentially eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy
SCD inhibition preferentially eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy Open
Identification of specific and therapeutically actionable vulnerabilities in acute myeloid leukaemia (AML) is needed to improve patients’ outcome. These features should be ideally present in many patients independently of mutational backgr…
View article: Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death Open
View article: Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death
Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death Open
Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phosph…
View article: Regulation and function of the palmitoyl‐acyltransferase ZDHHC5
Regulation and function of the palmitoyl‐acyltransferase ZDHHC5 Open
Protein palmitoylation (S‐acylation) has emerged as an important player in a range of cellular processes, and as a result, the palmitoyl‐acyltransferase (PAT) enzymes which mediate this modification have entered into the spotlight. Palmito…
View article: Author response for "Regulation and function of the palmitoyl‐acyltransferase ZDHHC5"
Author response for "Regulation and function of the palmitoyl‐acyltransferase ZDHHC5" Open
View article: S‐acylated Golga7b stabilises <scp>DHHC</scp> 5 at the plasma membrane to regulate cell adhesion
S‐acylated Golga7b stabilises <span>DHHC</span> 5 at the plasma membrane to regulate cell adhesion Open
View article: S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate desmosome assembly and cell adhesion
S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate desmosome assembly and cell adhesion Open
S-acylation is the only fully reversible lipid modification of proteins however little is known about how protein S-acyltransferases (PATs) that mediate it are regulated. DHHC5 is a plasma membrane-localised PAT with roles in synaptic plas…
View article: Global, site-specific analysis of neuronal protein S-acylation
Global, site-specific analysis of neuronal protein S-acylation Open